Labour Leader Jeremy Corbyn says the result shows that there is no majority for the prime minister's course of action in dealing with Brexit.
Theresa May "cannot keep ignoring Parliament and ploughing on to the 29th March without a plan", he says, adding: "she cannot keep running down the clock."
Jeremy Corbyn says it is "surprising" that Theresa May is not here for the result - and calls for the PM to come to the Commons and "admit her strategy has failed".
He asks Theresa May to "bring a coherent plan that can deal with the stresses and anxieties that so many people across the UK are feeling, and to prevent the catastrophe of a no-deal exit".
The Speaker offers the government frontbench the chance to respond, but they decline.
Government's Brexit motion defeated by majority of 45
BBCCopyright: BBC
BreakingGovernment defeated on Brexit motion
Brexit Debate
House of Commons
Parliament
MPs vote to reject the government's Brexit motion by 303 votes to 258 - a majority of 45.
The motion was a so-called 'neutral' motion, which says simply that the Commons "reiterates its support" for the Brexit strategy it backed at a vote last month.
In that vote, MPs had called for the Irish backstop plan to be replaced with 'alternative arrangements', but also stated their opposition to the idea of leaving without a deal.
Some Brexiteers had been unhappy with today's motion, saying it implies support for ruling out a no-deal Brexit.
The two amendments proposed by the Labour frontbench and the SNP have been defeated.
With Tory MP Anna Soubry not putting her amendment to a vote, a vote is now called on the main motion itself, a so-called 'neutral motion' tabled by the government, which reads:
Quote Message: this House welcomes the Prime Minister’s statement of 12 February 2019; reiterates its support for the approach to leaving the EU expressed by this House on 29 January 2019 and notes that discussions between the UK and the EU on the Northern Ireland backstop are ongoing.
this House welcomes the Prime Minister’s statement of 12 February 2019; reiterates its support for the approach to leaving the EU expressed by this House on 29 January 2019 and notes that discussions between the UK and the EU on the Northern Ireland backstop are ongoing.
The debate comes to an end - and the voting begins.
First up, Jeremy Corbyn pushes the Labour frontbench amendment to a vote, which leads to a division.
This amendment calls for ministers to re-submit their Brexit deal for a vote in Parliament by 27 February, or if not to give MPs another vote on an amendable motion to decide the next steps.
The result of the vote is expected at around 5:15pm.
Minister makes offer to Tory MP over amendment
Brexit Debate
House of Commons
Parliament
HoCCopyright: HoC
Brexit Minister Chris Heaton-Harris says Labour should be supporting the prime minister's deal if they want to do what is in the best interest of the country.
He also calls on Tory MP Anna Soubry not to push her amendment demanding the publication of cabinet briefing papers on the economic impact of a no-deal Brexit to a vote tonight.
He says the government is "happy to meet with her" to identify and publish the "information she seeks to have published".
In reply, Ms Soubry says the offer "seems like a sensible resolution", but adds that she "reserves the right" to move a similar amendment at a later stage.
Labour: PM 'putting party before country'
Brexit debate
House of Commons
Parliament
HoCCopyright: HoC
Shadow Brexit minister Jenny Chapman says the motion the government has tabled for debate today is "divorced from reality".
She says that British exporters and importers do not know what tariffs they will face in 44 days' time.
This is a "crisis of the Tory party's making," she says.
"We will never support a strategy that is so clearly putting short-term Tory party unity above the national interest," she adds.
She accuses Theresa May of "running down the clock, playing for time, and drifting towards no deal".
"She's putting party before country", she adds.
What is the government's motion today?
Brexit debate
ReutersCopyright: Reuters
The main motion being debated this afternoon is a motion tabled by the government.
It is a so-called 'neutral' motion, which says simply that the Commons "reiterates
its support" for the Brexit strategy it backed at a vote last month.
At that vote, MPs called for the Irish backstop plan to be replaced with 'alternative arrangements', but they also stated their opposition to the idea of leaving without a deal.
Some Brexiteers are therefore unhappy with today's motion, because they say it implies support for ruling out a no-deal Brexit - an option they want to keep on the table.
MPs must rule out no-deal - Lib Dem
Brexit debate
HoCCopyright: HoC
Liberal Democrat MP Tom Brake says MPs must rule out no-deal Brexit because it is causing uncertainty for businesses and would be "catastrophic" for the country.
He says the second thing MPs must do today is to "come out strongly" for the idea of holding a further EU referendum.
He adds that the Liberal Democrats will table an amendment on the 27th February which will call for this, as the people "deserve a final say".
'Not clear' which way Eurosceptic Tories will vote
Live Reporting
Sophie Morris and Richard Morris
All times stated are UK
PM 'conspicuously absent' from Commons
The Sun's political correspondent tweets:
Corbyn: PM must 'admit her strategy has failed'
Brexit Debate
House of Commons
Parliament
Labour Leader Jeremy Corbyn says the result shows that there is no majority for the prime minister's course of action in dealing with Brexit.
Theresa May "cannot keep ignoring Parliament and ploughing on to the 29th March without a plan", he says, adding: "she cannot keep running down the clock."
Jeremy Corbyn says it is "surprising" that Theresa May is not here for the result - and calls for the PM to come to the Commons and "admit her strategy has failed".
He asks Theresa May to "bring a coherent plan that can deal with the stresses and anxieties that so many people across the UK are feeling, and to prevent the catastrophe of a no-deal exit".
The Speaker offers the government frontbench the chance to respond, but they decline.
Government's Brexit motion defeated by majority of 45
BreakingGovernment defeated on Brexit motion
Brexit Debate
House of Commons
Parliament
MPs vote to reject the government's Brexit motion by 303 votes to 258 - a majority of 45.
The motion was a so-called 'neutral' motion, which says simply that the Commons "reiterates its support" for the Brexit strategy it backed at a vote last month.
In that vote, MPs had called for the Irish backstop plan to be replaced with 'alternative arrangements', but also stated their opposition to the idea of leaving without a deal.
Some Brexiteers had been unhappy with today's motion, saying it implies support for ruling out a no-deal Brexit.
MPs voting on May's Brexit strategy
Labour's call for another vote on the withdrawal deal by 27 February and an SNP bid to delay Brexit are defeated.
Read moreMPs vote on government motion
Brexit debate
House of Commons
Parliament
The two amendments proposed by the Labour frontbench and the SNP have been defeated.
With Tory MP Anna Soubry not putting her amendment to a vote, a vote is now called on the main motion itself, a so-called 'neutral motion' tabled by the government, which reads:
SNP amendment defeated with majority of 222
How MPs aimed to alter Brexit process
How MPs hoped to change the Brexit process when Theresa May brings the issue back to the Commons.
Read moreBreakingSNP amendment defeated
Brexit Debate
MPs have also voted to reject the SNP's amendment, by 315 votes to 93.
That's a government majority of 222.
Eurosceptic Tories 'to abstain on main Brexit motion'
Telegraph's Deputy Political Editor tweets:
How MPs voted on Labour amendment
MPs voting on SNP amendment
Brexit debate
House of Commons
Parliament
MPs are now voting on the SNP's amendment, which calls for the Brexit negotiation period to be extended by at least three months.
BreakingLabour amendment defeated
Brexit debate
MPs have voted to reject the Labour frontbench amendment by 322 votes to 306.
That's a government majority of 16.
Anna Soubry pulls her amendment
Conservative MP tweets:
MPs voting on Labour's amendment
Brexit debate
House of Commons
Parliament
The debate comes to an end - and the voting begins.
First up, Jeremy Corbyn pushes the Labour frontbench amendment to a vote, which leads to a division.
This amendment calls for ministers to re-submit their Brexit deal for a vote in Parliament by 27 February, or if not to give MPs another vote on an amendable motion to decide the next steps.
The result of the vote is expected at around 5:15pm.
Minister makes offer to Tory MP over amendment
Brexit Debate
House of Commons
Parliament
Brexit Minister Chris Heaton-Harris says Labour should be supporting the prime minister's deal if they want to do what is in the best interest of the country.
He also calls on Tory MP Anna Soubry not to push her amendment demanding the publication of cabinet briefing papers on the economic impact of a no-deal Brexit to a vote tonight.
He says the government is "happy to meet with her" to identify and publish the "information she seeks to have published".
In reply, Ms Soubry says the offer "seems like a sensible resolution", but adds that she "reserves the right" to move a similar amendment at a later stage.
Labour: PM 'putting party before country'
Brexit debate
House of Commons
Parliament
Shadow Brexit minister Jenny Chapman says the motion the government has tabled for debate today is "divorced from reality".
She says that British exporters and importers do not know what tariffs they will face in 44 days' time.
This is a "crisis of the Tory party's making," she says.
"We will never support a strategy that is so clearly putting short-term Tory party unity above the national interest," she adds.
She accuses Theresa May of "running down the clock, playing for time, and drifting towards no deal".
"She's putting party before country", she adds.
What is the government's motion today?
Brexit debate
The main motion being debated this afternoon is a motion tabled by the government.
It is a so-called 'neutral' motion, which says simply that the Commons "reiterates its support" for the Brexit strategy it backed at a vote last month.
At that vote, MPs called for the Irish backstop plan to be replaced with 'alternative arrangements', but they also stated their opposition to the idea of leaving without a deal.
Some Brexiteers are therefore unhappy with today's motion, because they say it implies support for ruling out a no-deal Brexit - an option they want to keep on the table.
MPs must rule out no-deal - Lib Dem
Brexit debate
Liberal Democrat MP Tom Brake says MPs must rule out no-deal Brexit because it is causing uncertainty for businesses and would be "catastrophic" for the country.
He says the second thing MPs must do today is to "come out strongly" for the idea of holding a further EU referendum.
He adds that the Liberal Democrats will table an amendment on the 27th February which will call for this, as the people "deserve a final say".
'Not clear' which way Eurosceptic Tories will vote
BBC Political Editor tweets: