Coached by Rohan Smith, 14-time Challenge Cup champions Leeds Rhinos most recently lifted the silverware in 2020 so have form, although they will have to up their performance from this time last season where they lost at the same stage of the competition in a home draw against Wigan Warriors.
Smith will be hoping the likes of James Bentley, Sam Lisone and Paul Momirovski returning from injury will see the side put in in better performance than last Friday night, when they lost 8-18 to St Helens in the Super League.
Visiting side St Helens are also no strangers to Challenge Cup success, having lifted the cup on 13 occasions, with their last victory being in 2021, Saints boss Paul Wellens also having received the Lance Todd trophy for the side during his playing career. Wellens will be hoping his team can cling to the momentum of last Friday night’s victory, even without the likes of Tommy Makinson who was forced to pull out of last weekend's fixture last minute due to a hamstring injury and is looking like he will still be absent tomorrow.
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Video caption: St Helens last won the Challenge Cup in 2021, defeating Castleford Tigers 26-12St Helens last won the Challenge Cup in 2021, defeating Castleford Tigers 26-12
Leeds boss Smith aware of Challenge Cup 'prestige'
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Video caption: St Helens come from behind to seal Super League win at Leeds RhinosSt Helens come from behind to seal Super League win at Leeds Rhinos
Leeds Rhinos head coach Rohan Smith is certainly aware of the "prestige and history" of the Challenge Cup going into Friday's huge sixth-round tie with old rivals St Helens.
The two clubs have enjoyed thrilling encounters in Grand Finals, Challenge Cup finals and numerous semi-finals.
Smith's own introduction to the competition came when dad Brian was boss of Hull and then Bradford.
"I've always followed the Challenge Cup,"
Smith told BBC Radio Leeds.
"I remember going to games when dad coached at Hull in the late 80s.
"I understand the prestige and the history, the rollercoaster that it is playing sudden-death."
His father Brian, one of the great coaches both in Australia with clubs such as St George, Sydney Roosters and Parramatta as well as in the northern hemisphere, took Bradford to the final in 1996 when Rohan was a teenager.
The journey through the rounds, and the experience of Wembley week and the day itself all left a lasting impression on the would-be coach.
"I went to Wembley when dad was at the Bulls in 1996, and that was a phenomenal experience, in a high-scoring exciting game," Smith added.
Coverage will be live
on BBC iPlayer and the BBC Sport website and app. You can also catch up with
the action for up to 30 days.
Friday, 22 March
Leeds Rhinos v St Helens – 19:50-22:05 - BBC
iPlayer, Red Button and BBC Sport website and app.
How to get into rugby league
BBC Sport
Video content
Video caption: 'Rugby stopped me going off the rails''Rugby stopped me going off the rails'
Rugby league is a fast and dynamic game, which
involves great strength, stamina and skill, and is played through the summer, so
no muddy pitches, or cold, wet training nights!
With so many variations, you don't have to
play the full version of the game to be part of it.
Whatever your age, gender, fitness level or
technical ability there is a version of rugby league that will suit you.
Whether you have played in the past or just
have a keen interest in developing talent, coaching opportunities are available
through the national rugby associations in England, Wales, Scotland and Northern
Ireland.
Live Reporting
All times stated are UK
Video caption: St Helens last won the Challenge Cup in 2021, defeating Castleford Tigers 26-12St Helens last won the Challenge Cup in 2021, defeating Castleford Tigers 26-12 Video caption: St Helens come from behind to seal Super League win at Leeds RhinosSt Helens come from behind to seal Super League win at Leeds Rhinos 
Video caption: 'Rugby stopped me going off the rails''Rugby stopped me going off the rails'
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Coached by Rohan Smith, 14-time Challenge Cup champions Leeds Rhinos most recently lifted the silverware in 2020 so have form, although they will have to up their performance from this time last season where they lost at the same stage of the competition in a home draw against Wigan Warriors.
Smith will be hoping the likes of James Bentley, Sam Lisone and Paul Momirovski returning from injury will see the side put in in better performance than last Friday night, when they lost 8-18 to St Helens in the Super League.
Visiting side St Helens are also no strangers to Challenge Cup success, having lifted the cup on 13 occasions, with their last victory being in 2021, Saints boss Paul Wellens also having received the Lance Todd trophy for the side during his playing career. Wellens will be hoping his team can cling to the momentum of last Friday night’s victory, even without the likes of Tommy Makinson who was forced to pull out of last weekend's fixture last minute due to a hamstring injury and is looking like he will still be absent tomorrow.
Video content
Leeds boss Smith aware of Challenge Cup 'prestige'
Video content
Leeds Rhinos head coach Rohan Smith is certainly aware of the "prestige and history" of the Challenge Cup going into Friday's huge sixth-round tie with old rivals St Helens.
The two clubs have enjoyed thrilling encounters in Grand Finals, Challenge Cup finals and numerous semi-finals.
Smith's own introduction to the competition came when dad Brian was boss of Hull and then Bradford. "I've always followed the Challenge Cup,"
Smith told BBC Radio Leeds. "I remember going to games when dad coached at Hull in the late 80s. "I understand the prestige and the history, the rollercoaster that it is playing sudden-death."
His father Brian, one of the great coaches both in Australia with clubs such as St George, Sydney Roosters and Parramatta as well as in the northern hemisphere, took Bradford to the final in 1996 when Rohan was a teenager. The journey through the rounds, and the experience of Wembley week and the day itself all left a lasting impression on the would-be coach. "I went to Wembley when dad was at the Bulls in 1996, and that was a phenomenal experience, in a high-scoring exciting game," Smith added.
Read more here
How can I watch?
All times are GMT and subject to change
BBC iPlayer
Coverage will be live on BBC iPlayer and the BBC Sport website and app. You can also catch up with the action for up to 30 days.
Friday, 22 March
Leeds Rhinos v St Helens – 19:50-22:05 - BBC iPlayer, Red Button and BBC Sport website and app.
How to get into rugby league
BBC Sport
Video content
Rugby league is a fast and dynamic game, which involves great strength, stamina and skill, and is played through the summer, so no muddy pitches, or cold, wet training nights!
With so many variations, you don't have to play the full version of the game to be part of it.
Whatever your age, gender, fitness level or technical ability there is a version of rugby league that will suit you.
Whether you have played in the past or just have a keen interest in developing talent, coaching opportunities are available through the national rugby associations in England, Wales, Scotland and Northern Ireland.