Our correspondents from across the globe have been closely following developments throughout the night, bringing us fresh reaction from the Middle East, the US and beyond.

Here's what they've been saying:

• Our White House correspondent - reacting to the news in the minutes after Trump confirmed the US had hit Iranian nuclear sites - reflected that Trump's quick decision is indicative of the way he carries out foreign policy
• These US attacks leave the door open for further strikes, writes our correspondent in Jerusalem - who also reflects that Israel's ongoing attacks on Iran leave the country in survival mode
• Retaliate fast, retaliate later or do nothing are the three most likely paths forward for Iran, writes our security correspondent Frank Gardner
• While our North American correspondent Anthony Zurcher speculates that Trump's decision to attack Iran is fraught with risk, both at home and abroad
• Our Middle East bureau chief says the entire region will be holding its breath this morning, as they wait to hear whether this marks the beginning of the end of this conflict, or the beginning of an even more deadly phase

Alice Cuddy
Reporting from Jerusalem

People in Israel have woken up this morning to news of US strikes overnight, and to the sounds of missile sirens.

Lawyer Efrat Eldan Schecter in northern Israel tells me over WhatsApp that she is "relieved and grateful" that the US "has taken decisive action against Iran's nuclear program", adding that she hopes it "marks a turning point towards a safer future for all".

In Tel Aviv, teacher Renee tells me over voice note of waking up this morning to the news.

"We didn't know what was happening. It's mixed feelings. I hope things get better but it's good we've got support - it's always good to have back-up," she says.

Asked how she feels about the risk of escalation, Renee says: "We don't really know what they have in their bag. We're hoping things don't escalate even further but who knows what they've got, hidden or not. We'll have to wait and see. We're all on edge here. I'm trying not to think about it too much but there is stress."

Starmer's response to strikes neither full throated support, nor criticismpublished at 08:16 British Summer Time 22 June

08:16 BST 22 June

Joe Inwood
World news correspondent

The response from the UK prime minister to the overnight strikes was neither full throated support – but nor was it any form of criticism.

Keir Starmer has been calling for de-escalation and negotiation; last night was neither.

What we can say is there will be a quiet sigh of relief that the UK government avoided a potentially difficult decision.

The most obvious base from where to stage the attack was Diego Garcia, the British-run base in the Indian Ocean. It is half the distance from the sites in Iran compared to the base in Guam.

Had the US asked to use the facility – and the government agreed – then that would surely be seen by Iran as the UK joining the war.

The fact that last night’s attack took place without the involvement of Diego Garcia will be a source of some relief to British policy makers, even as they worry about their wider implications.

• As we've just reported, the BBC understands the UK was not involved in US strikes on Iran

The BBC understands there was no UK involvement in the US attacks on Iranian nuclear facilities and the prime minister was told in advance they were happening.

Image source, Reuters

00:50 BST: Donald Trump says the US has carried out strikes on three nuclear sites in Iran – Fordo, Natanz and Isfahan.

01:56: Iran officially confirms the three nuclear sites were attacked.

02:43: Israeli Prime Minister Benjamin Netanyahu issues a statement saying “President Trump and the United States acted with a lot of strength”.

02:54: UN chief António Guterres calls the US move a “dangerous escalation”.

03:00: Donald Trump addresses the nation, warning Iran “must now make peace” or face "far greater" attacks.

05:31: Israel says Iran has launched a fresh strike.

06:00: The International Atomic Energy Agency says there is “no increase” in radiation levels at Iranian nuclear sites following the strikes.

06:47: The Israeli military says its air force has begun a new wave of attacks against “military targets” in western Iran.

Israeli police say six people with minor injuries have been evacuated from a damaged building in Tel Aviv after Iran's strikes.

Searches are still going on to find anyone trapped inside the damaged buildings, police add.

Image source, Israel Police

We've just had another update come through from the Israeli emergency services, which says that 16 people are now being treated for injuries following the reports of Iranian strikes.

Earlier, Magen David Adom said 11 people were injured in the early morning strikes.

The injured include:

• One man, approximately 30 years old, in moderate condition with a shrapnel injury to his upper body
• 15 people in mild condition with shrapnel wounds and other injuries

Image source, EPA

We're hearing from UK Prime Minister Keir Starmer now, who says the US has taken action to "alleviate" the "grave threat" of Iran's nuclear programme.

In a statement he says: “Iran’s nuclear programme is a grave threat to international security. Iran can never be allowed to develop a nuclear weapon and the US has taken action to alleviate that threat.

“The situation in the Middle East remains volatile and stability in the region is a priority. We call on Iran to return to the negotiating table and reach a diplomatic solution to end this crisis.”

Israel's campaign puts Iran on survival modepublished at 07:30 British Summer Time 22 June

07:30 BST 22 June

Hugo Bachega
Middle East correspondent, reporting from Jerusalem

The Israeli prime minister, Benjamin Netanyahu, is feeling vindicated.

From his 1995 book, Fighting Terrorism, to his famous speech at the United Nations Security Council in 2012, when he displayed the illustration of a bomb to explain how close, in his view, Iran was to obtaining a nuclear weapon, Netanyahu has long told the world Iran must be stopped.

Will Israel stop attacking Iran now?

Israeli military officials have repeatedly warned that this could be a prolonged campaign, and they have celebrated what they see as an extremely successful operation so far. They may see little reason to stop before inflicting even more damage.

Meanwhile, more and more Israeli officials, Netanyahu included, have hinted at regime change in Iran.

The hope seems to be that the bombing campaign will lead to a movement against the Iranian supreme leader, Ayatollah Ali Khamenei, toppling the Islamic Republic that has been in power since the revolution of 1979.

Which puts Iran on survival mode. The country has repeatedly rejected any deal that would see it giving up enriching uranium on its soil, a key US demand, saying it is its right.

In their weakest position in nearly five decades, Iran’s leaders will be under international pressure to accept an agreement, that will inevitably try to prevent any resumption of nuclear activities.

The alternative is more conflict, which could lead to the end of Khamenei’s rule and an uncertain future for the country.

Image source, Reuters

Iran has targeted several sites in Israel, including Ben Gurion Airport, according to Iranian state TV.

Other reported targets include support bases, command and control centres, and a biological research centre.

State media say the Islamic Revolutionary Guard Corps (IRGC) announced the attack was carried out using long-range missiles.

The Israeli military has just issued an update from the country's Home Front Command and says it is now safe for people to leave protected spaces and shelters in several areas across the country.

Search and rescue forces are operating in several parts of the country in which reports of fallen projectiles were received, the IDF adds.

About an hour ago, the IDF said it had identified missiles launched from Iran toward Israeli territory.

The Israeli military says that its air force has just begun a new wave of attacks against "military targets" in western Iran.

It comes after the Israel Defense Forces (IDF) issued a warning in the last hour that it had identified missiles being launched from Iran toward Israeli territory.

The IDF adds that it has also carried out strikes against missiles launchers in Iranian territory.

US President Donald Trump says American warplanes have bombed three nuclear sites in Iran, marking a significant escalation in the ongoing war between Iran and Israel.

• One of the targets was Fordo - a uranium enrichment plant hidden in a remote mountainside that is vital to Iran's nuclear ambitions
• Two other key nuclear sites - Natanz and Isfahan - were also hit
• Israeli officials say they were in "full co-ordination" with the US in planning these strikes
• The US contacted Iran through diplomatic channels on Saturday to say the air strikes were all it intended to do and that "regime change efforts" were "not planned", according to US officials speaking to the BBC's US partner, CBS News
• We do not yet know the full scale of the damage at the facilities - but the UN nuclear watchdog says there has been "no increase" in off-site radiation levels reported

Image source, MDA

Israel's emergency service, Magen David Adom (MDA), says 11 injured people are being taken to hospital after the latest Iranian strikes.

The injured include one person in moderate condition - a 30-year-old man with a shrapnel wound to his upper body. The other 10 people have light injuries with bruises.

Trump leaves door open for further attackspublished at 06:38 British Summer Time 22 June

06:38 BST 22 June

Hugo Bachega
Middle East correspondent

In a dramatic move, the US has joined Israel in its attacks on Iran, carrying out large-scale strikes on three key nuclear facilities, Fordo, Natanz and Isfahan, with President Trump saying they were “completely and totally obliterated”.

He warned Iran that it “must now make peace”, otherwise “future attacks would be far greater and a lot easier”.

What happens next?

Iran and its proxies had threatened to target US interests in the region in response to any direct American involvement in the conflict.

Its military capabilities, however, are significantly damaged after nine days of attacks, and the groups it supports, part of the so-called Axis of Resistance, have also been weakened.

Any retaliation could lead to more US attacks, as President Trump left the door open for further action: “Remember there are many targets left”.

How will Iran respond?published at 06:28 British Summer Time 22 June

06:28 BST 22 June

Frank Gardner
Security correspondent

Iran must now choose between three strategic courses of action in response to the US attack overnight.

• Do nothing. This could spare it from further US attacks. It could even choose the diplomatic route and rejoin negotiations with the US. But doing nothing makes the Iranian regime look weak, especially after all its warnings of dire repercussions if the US did attack. It may decide the risk of weakening its grip on its population outweighs the cost of further US attacks.
• Retaliate hard and fast. Iran still has a substantial arsenal of ballistic missiles after manufacturing and hiding these away for years. It has a target list of around 20 US bases to choose from in the broader Middle East. It could also launch ‘swarm attacks’ on US Navy warships using drones and fast torpedo boats.
• Retaliate later at a time of its own choosing. This would mean waiting until the current tension has subsided and launching a surprise attack when US bases were no longer on maximum alert.

The UN’s nuclear watchdog - the International Atomic Energy Agency (IAEA) - has just released a statement saying there has been "no increase in off-site radiation levels" reported after the US struck three nuclear sites in Iran.

"IAEA will provide further assessments on situation in Iran as more information becomes available," it says.

Tom Bennett
Reporting in Amman

While my colleagues have reported hearing multiple blasts over Jerusalem, I’m in Amman, Jordan, where sirens have gone off across the city twice this morning, signifying Iranian missile barrages headed towards Israel.

The missiles are not aimed at Jordan - but the Jordanian air force has carried out interceptions in recent days of missiles and drones it deems could land in its territory.

Interceptions cause a risk of missile fragments falling out of the sky.

Along with the waves of cancelled flights across the region, it’s just another sign of how this conflict impacts the whole Middle East.

Image source, Getty Images

Iran's foreign minister Seyed Abbas Araghchi condemns the US strikes as "outrageous" and says Iran is reserving "all options to defend its sovereignty".

"The events this morning are outrageous and will have everlasting consequences. Each and every member of the UN must be alarmed over this extremely dangerous, lawless and criminal behavior," he writes in a post on X.

Araghchi adds that the US has "committed a grave violation" of the UN charter as a member of the UN Security Council.

Image source, Reuters

If you're just joining us now - welcome to our live coverage. Here's a quick recap of the main developments in the past few hours:

• The US says it carried out strikes on three nuclear facilities in Iran: Natanz, Isfahan and Fordo - the latter is believed to be the most difficult and prized target
• In a televised address to the nation, Trump hailed the operation as a "spectacular military success", warning Tehran to quickly make peace or face "far greater" attacks
• The US reportedly used heavy bunker-busting bombs dropped from B-2 strategic stealth bombers and Tomahawk cruise missiles - details could be announced at a Pentagon briefing later on Sunday
• Iran's state media admit part of the Fordo site was "attacked by enemy strikes", but it is downplaying the extent of the damage
• Tehran earlier warned it would target American interests in the Middle East in retaliation for any US attack - so far it has fired missiles at Israel, with blasts heard over Jerusalem

• Israel welcomes the US involvement, with Israeli Prime Minister Benjamin Netanyahu saying the "bold decision" will "change the course of history"
• In the US, there was a mixed reaction from lawmakers roughly along party lines - with Republicans commending Trump, and Democrats warning that America is being dragged into another "open-ended" war

Stay with us, as we bring you all the latest news and analysis from our correspondents in the region, as well as photos and videos when we get them