Talking about the spread of the virus among the over-60s, Prof Van-Tam says the purple areas have increased.

"I really want to emphasise that it is the over-60s that really worries us most," he says.

England's deputy chief medical officer, Jonathan Van-Tam, says the shading on these maps shows the dark purple "problem area" has "extended from coast to coast now".

But he says "the rate of change is more variable".

Image source, Downing St

Boris Johnson begins his press conference by saying the countries that are most successful in their fights against coronavirus are adopting regional restrictions.

That's why last week we launched the three-tier system for England, he says.

Mr Johnson adds that since then, the government has been undertaking discussions with local leaders.

We're just minutes away from the PM's press conference.

He'll be joined by the medical director for NHS England, Stephen Powis, and England's deputy chief medical officer, Jonathan Van-Tam.

It comes after talks collapsed between the government and local leaders in Greater Manchester over a financial package for the region, ahead of it entering the top level of coronavirus restrictions.

Image source, Getty Images

In early summer, travellers from the UK could visit popular holiday destinations such as Spain, Italy and France without having to quarantine.

But rising coronavirus rates mean there are now only a handful of places travellers from England can visit without facing quarantine or other restrictions - either when they arrive at their destination, or return.

These destinations include Greece (apart from Mykonos), Gibraltar and Sweden.

Testing passengers for coronavirus could be one way to make travel to more destinations possible, by providing proof of a negative result.

Heathrow, for example, has started offering an £80 coronavirus test for travellers to Hong Kong, which requires a recent negative test for entry from the UK.

Read more about where you can visit without quarantining

A further 21,331 coronavirus cases in the UK have been announced by the government,, external taking the UK's total to 762,542.

The official figures also announce a further 241 deaths.

These include 213 in England, 15 in Scotland, 10 in Wales and three in Northern Ireland.

We've heard from Andy Burnham. Next it's time to hear from UK Prime Minister Boris Johnson.

He is expected to give a news conference at 17:00 BST.

Joining him will be the medical director for NHS England, Prof Stephen Powis, and England's deputy chief medical officer, Prof Jonathan Van-Tam.

Kevin Fitzpatrick
BBC North West political editor

A rollercoaster week of talks came to a juddering halt over £5m.

After tense meetings, a midday deadline and a threat to impose tier three anyway, all signs pointed to a deal when Greater Manchester’s leaders were offered £60m to help businesses forced to close.

It’s similar, proportionate to population, to what Lancashire and Liverpool City Region had received.

But when the leaders went back for £5m more, ministers said no and the talks quickly broke up.

Both sides accuse the other of refusing to budge as a public battle to pin blame gets under way.

And all the while 2.8 million residents of Greater Manchester anxiously await their fate under tougher restrictions.

Burnham ends with a message addressed directly to the people of Greater Manchester, as he acknowledges the uncertainty felt over the last week, saying: "I know this is going to be a difficult time for you."

He says: "We took this stand for you. We will carry on fighting for you. We will carry on putting your health first. But health is more than the virus. We will support people's health in the broadest possible sense.

"So tough days lay ahead. Please, everybody, observe the law at all times and follow the public health advice. Above all else, please look out for each other, as I know you will."

Burnham says he does not believe we can proceed by "grinding communities down".

"We are asking a lot of the public at this difficult time and we need to carry them with us, not crush their spirit.

"We need national unity and that is why I now look to Parliament to intervene and make a judgement on a fair financial framework for tier-three lockdowns.

"Because make no mistake, this was not just about Greater Manchester. All parts of the country may find themselves in a tier-three lockdown at some point this winter."

"At no point today were we offered enough to protect the poorest people in our communities," Andy Burnham says.

He says he is still willing to do a deal "but it cannot be on the terms the government has offered today".

"How can we carry the public with us through this pandemic if we are forcing them to lose their income without supporting them?" he asks.

Mr Burnham says "it cannot be right to close people's place of work" without giving them proper support so they can look after themselves.

"We could only accept further restrictions with further financial support," he says.

He says he and other local leaders in Manchester put forward a costed and detailed package of measures "to support people on the lowest incomes" and asked for £15m a month.

Mr Burnham says the money would top up people's salaries to 80%.

"This would cost £90m to the end of the financial year," he says.

He says they were prepared to reduce it to £70m and then to £65m.

"Not what we wanted, what we needed," he adds.

"But the government refused to accept this. At 2 o'clock today they walked away from negotiations," he says.

Image source, PA Media

Greater Manchester's mayor Andy Burnham is giving a press conference outside Bridgewater Hall in Manchester.

Talks collapsed earlier between him and the government over whether the region will enter tier three - the highest level of coronavirus lockdown restrictions.

It's now expected that Greater Manchester will move up to tier three - the first region to have restrictions imposed on it, rather than agreeing.

Mr Burnham is joined by leaders of some of Manchester's councils and says it "reflects the unity" in Manchester

People here have been living under restrictions for three months, he says - and it's taken "a heavy toll"

"To accept any further restrictions would be certain to increase levels of poverty, homelessness and hardship," he says.

People "too often forgotten by those in power" are most affected, he says.

Image source, PA Media

Labour leader Keir Starmer says the collapse of talks between Greater Manchester leaders and the government is "a government failure".

He says: "The Conservatives have been treating local communities, particularly in the Midlands, North West and North East, and their leaders with contempt.

"Labour recognise the need for stricter public health restrictions. However, that must be accompanied by extra financial support.

"Labour will continue to support Andy Burnham in the fight for people's jobs, lives and livelihoods."

A reminder that we are expecting to hear from Starmer's Labour colleague Burnham in his role as Greater Manchester mayor in a few minutes.

Usually, three million visitors head to Blackpool's Golden Mile seafront in the last two weeks of October for it's illuminations.

It's usually the seaside towns' "busiest" fortnight, locals say.

But this year, tourism bosses at Blackpool Council say the restrictions - with the area now in the highest tier - have been "catastrophic" and visitor numbers have plummeted.

Colin Sinderson operates Blackpool Cinderella Carriages along the promenade.

"It's dead," he said. "We're down 90% on our takings. Nobody's here."

Read more here.

Image source, PA

The tier three rules set to be introduced in Greater Manchester mean pubs and bars not serving food must close.

The real estate adviser Altus Group estimates this could lead to the closure of 1,800 pubs and 140 wine bars.

We're expecting to hear from Andy Burnham in a news conference at 16:00 BST giving his response to the imposition of measures. It is likely that the fate of Manchester's bars and their staff will feature among his comments.

The leader of Durham Council has called for an investigation into the decision not to charge the prime minister’s adviser Dominic Cummings and his family backdated council tax.

A home was built without planning permission on Mr Cumming’s father’s farm on the outskirts of Durham. The Valuation Office Agency also waived a council tax bill on a second converted property on the same site.

Councillor Simon Henig says the agency’s decision to not claim unpaid council tax dating back to 2002 must be investigated.

Mr Cummings travelled from London to Durham in March after his wife became ill with suspected coronavirus. He stayed in a property in the grounds of his father’s house, North Lodge.

Durham Council says it’s started collecting three sets of council tax in respect of North Lodge from the start of this month.

Andrew Gwynne, MP for Denton and Reddish in Greater Manchester, told the BBC News Channel: "It would have been nice to have reached a conclusion that both met the public health challenge facing Greater Manchester but also the very severe economic challenge that is facing Greater Manchester.

"Because, let's not forget, this isn't a new imposition of lockdown measures on Greater Manchester. We've had them in place since 29 July when the government put us into local lockdown measures.

"It has been a long and hard summer for many businesses and without the additional support, tier three is going to decimate many of those businesses that have just about clung on for the last 12 weeks. And with it, people will be losing their jobs [ahead of] a very uncertain dark and long winter."

Maddy Savage
BBC News, Stockholm

Image source, Getty Images

People living in the Swedish university city of Uppsala and the surrounding area have been advised against any physical contact with those they don’t live with, organising or attending private parties and taking public transport for the next two weeks.

Shops and sports venues have also been asked to take steps to avoid overcrowding.

Uppsala, where there has been an uptick in Covid-19 cases in recent weeks, is the first part of the country to introduce stricter local coronavirus recommendations.

Sweden has largely relied on voluntary measures to slow the spread of the virus, alongside a ban on public gatherings of more than 50 people, table service at bars and restaurants and, until the start of this month, a ban on visits to elderly care homes.

The move in Uppsala comes after Sweden's regional health authorities were given increased powers on Monday to ask the Swedish Public Health Agency for stricter regional guidelines.

Sweden’s Minister for Health and Social Affairs Lena Hallengren also announced on Monday that the government is hoping to pass a new temporary national law which would formally limit the number of people on transport and in shops.

But she suggested this would not be in place until the summer.

Dominic Casciani
Home Affairs Correspondent

Tier three restrictions for Greater Manchester won't just effect the people and the businesses - the police may also find themselves between a rock and a hard place.

They must enforce the lockdown - and the national policing strategy since March has been to "encourage" people to comply, rather than dish out fines all day long.

That fits with the principle of policing by consent - but this situation is unprecedented. Greater Manchester Police will have to enforce a form of lockdown that is opposed by its locally-elected leaders, including the Mayor Andy Burnham, because of what they believe is inadequate support for the region's workers and economy.

Mr Burnham has responsibility for the local police force itself - and a lot of people support his position. The law is clear - if a region is placed inside tier three, the rules must be followed. Ministers have also just given GMP £1,733,541 to cover the costs of visible patrols to ensure members of the public are complying with restrictions.

The question is whether GMP will find people flatly refusing to comply because they've taken their lead so far from the mayor, rather than a prime minister whom they regard as remote from the reality of their lives.