Thanks for following our live updates today.

For more on the pandemic in the UK, Panorama this evening shares the stories of some of those who have lost their lives. It's called 100,000 Deaths and is on BBC One at 20:30 GMT.

Today's updates were brought to you by Alex Kleiderman, Alexandra Fouche, Claire Heald, Ella Wills, George Wright, Jennifer Meierhans, Justin Parkinson, Katie Wright, Lucy Webster and Sarah Collerton.

Image source, EPA

We're about to bring our coverage to an end. Here's what's been happening around the UK.

• It has been a bleak day in the progress of the pandemic as the number of people who have died with Covid-19 in the UK has surpassed 100,000
• The prime minister says he is "deeply sorry" and takes "full responsibility for everything that the government has done"

• The number of daily deaths is likely to come down "relatively slowly" before the effects of the current lockdown and vaccines are felt, the Chief Medical Officer Prof Chris Whitty has warned
• The total number of people in the UK who have received their first Covid jab is 6.8m
• But the Welsh government has missed its target of vaccinating 70% of people aged 80
• The number of people out of work has risen to 1.72m, its highest level in almost five years, amid the impact of the pandemic
• Ministers are holding talks about making travellers coming to England quarantine in hotels, with an announcement expected soon
• And 31 Met Police officers who broke coronavirus rules to get haircuts are facing £200 fines

Image source, Getty Images

Thanks for joining us today. Here are some of the biggest developments from around the world.

• In the Netherlands, the government says it will not lift a curfew, after a third night of violent protests against increased Covid curbs across the country
• Germany's health ministry and AstraZeneca have rejected reports that cast doubt on the effectiveness of the drug-maker's vaccine for older adults
• President Joe Biden has said he expects the United States will soon be able to vaccinate 1.5 million people a day
• Italy has reported 541 coronavirus-related deaths, up from 420 the day before. It comes as Italian Prime Minister Giuseppe Conte resigns amid divisions over spending in the pandemic
• Mink farmers in Denmark - the world’s largest producer of mink pelts until a coronavirus cull - have been given a compensation package worth around £2.2 billion
• People have been arrested for breaking Covid rules protesting against the culturally sensitive Australia Day holiday
• Thousands of teachers and students in France have been holding demonstrations to demand better working conditions during the pandemic
• The EU has warned vaccine producers they must deliver agreed supplies, amid fears reductions could seriously hamper its inoculation drive. AstraZeneca and Pfizer-BioNTech have both said production problems mean they cannot supply the expected numbers

Michael Bristow
BBC World Service Asia Pacific editor

Image source, Getty Images

Philippines President Rodrigo Duterte has abandoned plans to allow some children out of their homes for the first time in 10 months.

They've been cooped up to prevent the spread of the coronavirus.

Under-15s have been unable to legally go outside since March - one of the toughest virus restrictions on children anywhere in the world.

It has had an effect on their schooling and mental health, as well as the economy because family trips have been impossible.

Last week though, the government finally said 10 to 14-year-olds would be allowed out from February.

But President Duterte has now rescinded that order after the more contagious UK variant of the virus was discovered.

Duterte told children they'd have to continue watching TV instead.

Image source, Getty Images

While the UK reaches a milestone in terms of the number of deaths today, it is one year ago that the Chinese government locked down the city of Wuhan.

For weeks beforehand, officials had maintained that the virus outbreak was under control - just a few dozen cases linked to a live animal market.

But in fact, coronavirus had been spreading throughout the city and around China.

We look back at those five critical days early on in the outbreak.

Hugh Pym
BBC News Health Editor

Despite the strains coronavirus is putting on the system, as hospital admissions for coronavirus continue at a high rate, there is still kindness and new life in NHS hospitals.

I went to Kings Mill Hospital, part of Sherwood Forest Hospitals Trust, to meet the patients and staff.

Among them was the Reverend Edith Dawson who told me sweeties and a smile go a long way at the moment.

BBC Radio 5 Live

As the UK registers more than 100,000 deaths of people with coronavirus, today, 5 Live has been hearing from people about how they are coping with the grief at losing their loved ones to coronavirus.

Jamie Brown’s dad Tony was 65 when he died with Covid-19 last March.

Speaking to 5 Live’s Naga Munchetty, Jamie said his dad was beginning to retire, but travelling to London one day a week, when he became ill.

"He was meant to be putting his feet up, having worked incredibly hard to do so - and that was taken away from him."

Jamie is a member of the Covid-19 Bereaved Families for Justice group and says the group helped him realise he’s "one in a sea of people who are feeling this... collective grief and collective rage (that) you’ve been so terribly let down".

Listen back on the free BBC Sounds app.

Jake Horton
BBC Reality Check

Image source, Getty Images

President Joe Biden has said that the US might be able to boost its daily vaccination roll-out targets after criticising the Trump administration’s record.

Biden, who has described the previous vaccine programme as a "dismal failure", has committed to getting 100 million vaccine doses done in his first 100 days and has since said: "I think we may be able to get that to 1.5 million a day, rather than one million a day."

Is he right about the vaccine roll-out under the Trump administration?

As of 20 January, when Biden became US president, about 16.5 million vaccines had been administered.

That is some way off the Trump administration's target of vaccinating 20 million people by the end of 2020. In fact, fewer than three million people had received a jab by 31 December.

Vaccinations have sped up since the start of the year.

The daily average for the week before Trump left office was less than 900,000, according to Our World in Data, external.

That figure has since risen above one million doses a day, and Biden has come under some scrutiny for not setting a more ambitious target.

When you look at the countries doing the most vaccinations by population, the US is fourth after Israel, the UAE and the UK in terms of doses per 100 people.

Read more here

Reality Check

Image source, Getty Images

Israel has the highest per capita vaccination rate in the world - but vaccines are yet to be rolled out to Palestinians in Gaza and the West Bank, viewed as occupied territories by the international community.

Israel’s health minister says it is the Palestinian Authority’s responsibility to provide healthcare under an interim deal for self-rule in Palestinian areas.

But UN human rights experts say there are international rules about the duty of an occupying power to provide healthcare - although Israel often argues it isn't technically occupying the West Bank and Gaza.

Palestinians in occupied East Jerusalem are entitled to be vaccinated against Covid - they have Israeli residency status. And medics working in Palestinian hospitals there are also getting vaccines.

Some health experts and business leaders have also called for Israel to include other Palestinians in its vaccine programme, as around tens of thousands of Palestinians travel daily to work in Israel and in Israeli settlements in the West Bank.

The Palestinian Ministry of Health - which operates in the West Bank – said they are doing deals with four companies that will provide enough vaccines for 70% of its people, and will get another 20% from the World Health Organization-backed Covax scheme.

But there are few details at the moment about when vaccines will start or who will receive them.

Read more here

Image source, @FloellaBenjamin

Among the figures on the pandemic in the UK today came news that more than 6.85m people have had a coronavirus vaccination first dose.

Another 279,757 people had received a jab as of Monday, official figures show., external

One of those getting a vaccination on Tuesday was actress and TV presenter Floella Benjamin, who tweeted a picture of the occasion, external.

Baroness Benjamin, 71, who made her name as the host of TV's Play School in the 1970s, is now a campaigner for young people.

Image source, AFP

Mink farmers in Denmark - the world’s largest producer of mink pelts until a coronavirus mass cull - have been given a compensation package worth more than 19 billion Danish kroner (£2.2bn).

It was voted through by MPs late on Monday.

The agriculture minister said it was a chance to move on, while the Danish mink breeders association said the industry would never return, as China and Poland could produce mink furs much more cheaply.

Mink farmers were ordered to destroy their entire stock of about 17 million animals last November, over fears that a mutant strain of Covid-19 could pass from mink to humans.

But chaos followed.

The scientific basis of the order came into question, and mass graves appeared to be poisoning soil and water supplies.

The issue led to the resignation of the previous agriculture minister.

Anna Holligan
BBC News Hague correspondent

Image source, EPA

The ignition of discontent has rocked the core of Dutch society.

In the absence of any legitimate way to socialise, is this simply an outlet for young men to feel part of something, their masks concealing their identities and enabling them to violently channel their frustrations?

There are more sinister influences at play. Messages on social media, overt and covert, have whipped up anger. Misinformation has even been spread by some politicians.

Some feared a curfew would be a tipping point, as Dutch restrictions tighten while some neighbouring countries relax their rules. The vast majority of people in the Netherlands are peacefully observing the curfew.

The unrest was initially seen as a response to the first "stay-at-home" order imposed since Nazi occupation during World War Two. That notion has been dismissed by Prime Minister Mark Rutte, who said the rioters were simply criminals and would be treated as such.

But there are simmering anxieties in Dutch towns and cities, and with less than two months before a general election, voters are vulnerable and the streets volatile.

Away from UK news now, and nearby, in the Netherlands, the Dutch government says it will not lift a curfew, after a third night of violent protests against increased Covid curbs.

Shops in Rotterdam and other cities were looted and Finance Minister Wopke Hoekstra condemned the violence, saying: "It's scum doing this".

More than 180 arrests have been made.

The Dutch chief of police said the riots no longer had "anything to do with the basic right to demonstrate".

The criminal violence had to stop, said Prime Minister Mark Rutte.

A night-time curfew from 21:00 (20:00 GMT) to 04:30 (03:30 GMT) was imposed last Saturday to help to halt the spread of the virus. Anyone caught violating it faces a €95 (£84) fine.

Read more here

England's Chief Medical Officer, Prof Chris Whitty says while the coronavirus death rate has flattened, it remains at a very high rate, and "there will unfortunately be additional deaths".

He was speaking at this afternoon's Downing Street briefing.

Image source, Reuters

There have been more than 3.5 million confirmed cases of coronavirus in the UK and more than 100,000 people have died, government figures show.

You can look up how many cases are near to you here.

Reality Check

Image source, PA Media

At his Downing Street briefing this evening, Prime Minister Boris Johnson said: “I think the amount we invested in the NHS, even before the pandemic began, was more than any time in modern memory.”

In 2018, the government pledged that spending on the NHS in England would increase by £20.5bn by 2023-24.

This meant that the NHS budget would increase by 3.2% a year, once inflation was accounted for.

However, it is still substantially below the 6% annual growth seen under the Labour governments in power between 1997 and 2010, according to the Institute for Fiscal Studies.

It’s important when comparing spending to include inflation, because it accounts for the fact that things get more expensive over the years.

Since the crisis began, the NHS budget has increased dramatically.

In the most recent year, the Department of Health and Social Care’s budget went up by £50bn, but it is still unclear whether the health service will receive more money once the crisis has ended.

"She was a passionate, caring, humorous and larger-than-life character."

"He is one of a kind and will be greatly missed."

"He had such a zest for life."

More than 100,000 lives have been lost to coronavirus in the UK - victims of a pandemic that has claimed two million deaths worldwide.

We have gathered tributes to more than 680 of those who have died - including words of remembrance from friends, family and colleagues.

Read the tributes here.

George Bowden
BBC News

Image source, Getty Images

The UK government is expected to announce plans for a form of hotel quarantine for international arrivals into the country.

While exact details of the policy remain unclear, similar schemes are already in place across the world, including in Australia and New Zealand.

Some travellers have been telling us about their experiences.

After finally securing her family's place in Australia's quarantine system, Keri McMenamin prepared for the worst - and ordered a vacuum cleaner.

The 38-year-old was returning to the country with her husband and two children after securing a job offer - leaving the UK in the middle of the coronavirus pandemic last year.

"It is literally luck of the draw," she says of where her family would spend 14 days together once they arrived. "You didn't know what to expect."

Read more about the experiences of Keri and others here.

Image source, Amber Jeffrey

The figure of more than 100,000 deaths is a devastating number and it leaves behind many thousands of grieving friends and families. So how can you support someone through the loss of a loved one?

"For every person who dies, around eight to 10 people are significantly affected," psychotherapist Julia Samuel tells Radio 1 Newsbeat.

Restrictions on going to funerals and rules around household mixing mean the normal support networks might not be as easy to reach.

"Your friend will need your support for a lifetime," Amber Jeffrey says. Amber set up the Grief Gang podcast and Instagram page, external after her mum Sue died. She said the idea was to reach out to others like her.

Here's what you can do to help someone dealing with grief.

Radio 4 PM

Image source, Imperial College

The epidemiologist whose modelling prompted the UK government to impose the first lockdown last March says he believes more action in the autumn of last year could have saved lives.

Speaking as more than 100,000 deaths were recorded, Prof Neil Ferguson told BBC Radio 4’s PM programme: "The new variant was unpredictable and did change our understanding of how much was needed to control spread, but we did just let the autumn wave get too far."

Asked if there was one thing that could have made a difference, he added: “In some sense back in March we had much less information to go on than in September.

"Had we acted both earlier and with greater stringency back in September when we first saw case numbers going up, and had a policy of keeping case numbers at reasonably low levels, then I think a lot of the deaths we’ve seen - not all by any means, but a lot of the deaths we’ve seen in the last four or five months - could have been avoided.”