Steve Barclay has just confirmed that he is no longer health secretary and is returning to the backbenches.

In a tweet, he wished Liz Truss "every success for the future".

Jayne McCormack
BBC News NI political correspondent

Northern Ireland seems to be the cabinet job that Liz Truss has most been struggling to fill.

It is after all often viewed as a poisoned chalice that brings many challenges and little influence.

Early reports were that Tory heavy hitters like Sajid Javid and Penny Mordaunt had turned it down.

Ironically Belfast-born Junior Northern Ireland Minister Conor Burns - who had been pushing for the role - looks set to be empty-handed.

Now Chris Heaton-Harris, the chief whip, is being talked up as the next MP to pack their bags for Belfast.

But if the prime minister has an in-tray from hell, the new secretary of state's won’t be much better.

Former Transport Secretary Grant Shapps, a man who came out to defend Boris Johnson on the airwaves during many sticky moments in his premiership, has confirmed he will not have a cabinet post in Liz Truss's new government.

He says he will return to the backbenches with a "strong, independent voice".

Image source, Lucy

Nurse Lucy says she "doesn't hold out much hope" for Liz Truss fixing issues within the NHS - something the new PM just said was one of her early priorities.

"We need more staff, we need a pay rise, we need more funding," says Lucy. "If [Truss] wants to deliver, that's what she needs to give us."

Speaking about the number of nurses leaving the NHS, Lucy tells Radio 5 Live that many can't afford to stay.

"She needs to bring back the bursary which basically paid nurses to train.

"My colleagues who are paying back student loans are in £30k of debt after their nursing degree, they can't afford it, they've gone elsewhere."

Speaking about her own finances, Lucy says she's "made cutbacks" but is now regularly ending up in her overdraft two days after payday.

Dominic Raab, deputy prime minister and justice secretary under Boris Johnson, has confirmed he is returning to the backbenches and will not take up a post in Prime Minister Liz Truss's cabinet.

Meanwhile the leader of the Liberal Democrats has reiterated his call for a general election following Liz Truss's first speech as prime minister.

In a statement, Sir Ed Davey said it was time for the new PM to "do the right thing" by cancelling the winter energy price rise and then "call a general election".

He said he was "shocked" that Truss and the Tory party had "utterly failed to come up with any ideas to help our country through the cost of living crisis.

"Their failure has pushed businesses to the brink and caused extreme anxiety for families and pensioners."

Sir Ed said the only way to solve the cost of living crisis was "to get Conservatives out of power once and for all".

Reacting to Liz Truss's first speech as prime minister, the Labour MP Thangam Debbonaire questions whether the speech was worth all the wait.

"We had such a build-up with the motorcade going through the rain and was it going to rain on her parade or not?

"In the end, she got lucky with the rain but really did the country get lucky with what she said?"

Debbonaire points out that the Conservatives have been in government for the past 12 years.

Liz Truss "talked about this country being built on people who get things done," says Debbonaire. That's absolutely right, she says, "but it does rather seem that doesn't include her or the previous three Tory prime ministers."

As we've reported, Liz Truss's supporters clapped and cheered as she made her speech.

But the PA news agency says that outside the security cordon of Downing Street some protesters played loud music including the song Mad World written by Tears for Fears.

Chanting from protesters and an air horn could also be heard as Liz Truss delivered her speech.

In her speech, Liz Truss listed three immediate priorities she would tackle as prime minister:

• The economy: Truss said she would focus on "getting Britain working again" with a "bold plan to grow the economy through tax cuts and reform". She said she would "cut taxes to reward hard work and boost business-led growth and investment" as part of her mission to "get the United Kingdom working, building and growing". She added that she would "make sure that we are building hospitals, schools, roads and broadband"

• Energy: Truss promised to "deal hands on with the energy crisis caused by Putin's war". She said she would "take action this week to deal with energy bills and to secure our future energy supply"
• The NHS: The PM said she would ensure that people could get doctors' appointments, and access to the NHS services they need. "We will put our health service on a firm footing," she said

US President Joe Biden sent his congratulations to Liz Truss as she finished her speech.

Ione Wells
Political Correspondent, BBC News

This wasn’t a long speech, nor a hugely upbeat or energetic one. There was certainly a tone that reflected some of the challenges ahead - the war in Ukraine and rising energy bills to mention just two - and a change of tone from the characteristic “boosterism” we heard from Boris Johnson this morning.

Liz Truss started by paying tribute to her predecessor.

But then she reeled off a list of her priorities including growing the economy through tax cuts and tackling the energy crisis.

Her supporters cheered her as she finished her speech.

Image source, Reuters

Liz Truss's first speech as prime minister is over.

Stay with us as our correspondents digest the content of that speech.

We'll bring you the latest reaction to the expected cabinet announcements as well.

"Our country was built by people who get things done," Truss says.

She adds that she's "confident that together we can ride out the storm, we can rebuild our economy and we can become the modern brilliant Britain that I know we can be".

The prime minister says she will make sure people can get doctors' appointments and the NHS services they need.

"We will put our health service on a firm footing," she says.

Lots of MPs are still bunched in the corner of Downing Street, some are a bit drenched from the rain earlier, watching on and listening to Liz Truss make her address.

She says she plans to deal "hands-on" with the energy crisis which she says has been caused by Vladimir Putin's war.

As prime minister Liz Truss says she will pursue three early priorities: growing the economy, tackling the energy crisis and improving healthcare.

As she repeated throughout the Tory leadership contest, she says she has a "bold plan" to grow the economy through tax cuts and reform.

She says she will drive reform in her mission to get the UK working, building and growing.

She says her government will "transform Britain into an aspiration nation with high paying jobs, safe streets and where everyone everywhere has the opportunities they deserve.

"I will take action this day and every day to make it happen."

Continuing her speech Liz Truss says now is the time to tackle things holding Britain back.

She pledges more investment in building roads and rolling out broadband. Great jobs are needed all over the country, she says.

Liz Truss says what makes the UK great is the fundamental belief in freedom, enterprise and fair play.

The British public has shown grit, courage and determination time and time again and we now face the global headwinds caused by the war in Ukraine and Covid, she adds.