We're now ending our live coverage of the arrest and death of the main suspect in the stabbing spree that claimed the lives of 10 people in Canada on Sunday.

Myles Sanderson died after experiencing "medical distress" after his arrest on Wednesday, police said, without giving further detail.

They also declined to comment further on how his brother Damien, who is accused of helping in the murders, died earlier this week.

His body was found on Monday, and police say they suspect his brother may have killed him.

Our live coverage was provided by Max Matza, Holly Honderich, Jessica Murphy, Nadine Yousif, Robin Levinson-King and Grace Conley, and edited by Rebecca Seales.

Canadian PM Justin Trudeau will be holding a news conference on Thursday from the west coast city of Vancouver.

It's safe to assume that he'll be asked extensively about the investigation by journalists there.

Earlier on Thursday, he plans to speak on the phone with US President Joe Biden.

Trudeau has been introducing tough new anti-gun laws in recent months, last month imposing a total ban on the import of handguns.

It remains to be seen what his administration can do to prevent future mass stabbing attacks.

Jessica Murphy
BBC News, Prince Albert, Saskatchewan

In a story that has had many twists, there was a final one this evening: that suspect Myles Sanderson died after being taken into custody.

And in a story that also has many unresolved questions, there was another to add: the circumstances of that death, particularly given photos have emerged that seem to show him standing up as he was being arrested.

RCMP Assistant Commissioner Rhonda Blackmore didn't have many answers to offer.

Asked if he could have died from an overdose - he had a documented history of substance abuse - Blackmore gave no more details.

She also refused to say whether Narcan, a drug given to stop overdoses, was administered.

"I can't speak to the specific manner of death", she said, adding that how he died was part of the ongoing investigation.

Image source, Facebook/ RCMP

Here's what we've just heard from police:

• Myles Sanderson died "shortly after" his arrest, according to RCMP Assistant Commissioner Rhonda Blackmore
• She refused to describe his manner of death, only saying it was due to "medical distress" and adding that life-saving measures were performed by police and ambulance workers
• He confirmed to police "through verbal identification" that he was the fugitive they were looking for after he was stopped driving on a rural highway between Prince Albert and Saskatoon
• A knife was found inside his stolen white Chevrolet Avalanche, and he was the only occupant of the vehicle
• His brother, Damien, who was found dead on Monday, is still considered a suspect in the killing of 10 people in a stabbing rampage on Sunday
• Over 120 witness interviews have conducted thus far, but police say the motive for the attack may never been known

The police press conference is over.

They confirmed that Myles Sanderson died following his arrest, but did not provide details on how he died.

They said more would be revealed as the investigation continued, and urged the public to continue to share information pertaining to the case.

Blackmore said it's traumatic for victims to recount memories.

The investigation has included more than 100 interviews with victims and witnesses and members of the public.

"People want to understand what happened here and how that unfolded," she said.

She acknowledged this was just the first step in victims' healing process and that many questions remain unanswered.

"They can rest easy tonight knowing that Myles Sanderson is no longer a threat to them," she said.

Damien Sanderson was found dead on Monday, after being named a suspect and charged with first-degree murder along with his brother.

His body was found near other victims around James Smith Cree Nation.

"At this point in time, he is considered a suspect in the homicides that were committed," Blackmore says.

Police said his injuries did not appear self-inflicted at the time. They did not elaborate during Wednesday's press conference.

As people hear updates from police on Myles Sanderson's arrest, several gathered in Prince Albert, Saskatchewan for a sombre vigil.

"Tomorrow we start the process on our grieving", said James Smith Cree Nation chief Wally Burns to mourners, some of whom wiped away tears.

“I’m holding back a lot of hurt, a lot of anger. I wish this was just a dream, but it’s not.”

It is one of several vigils that have taken place or are planned for the coming days in honour of the 10 victims who died in the mass stabbing attacks.

A collective prayer for James Smith Cree Nation and Weldon residents will also take place at First Nations University of Canada in Regina on Friday.

Words of solidarity have poured in from across the nation and around the world.

The Queen has also sent her condolences, with a statement earlier today saying she was mourning "with all Canadians at this tragic time".

Police say there were signs the now-deceased suspect was injured before his arrest.

Initial reports on Wednesday, when he was spotted near Wakaw, indicated he may have had an injury.

A vehicle was broken into in Weldon, after the attacks on Sunday, and it appeared he may have stolen a first-aid kit.

Jessica Murphy
BBC News, Prince Albert, Saskatchewan

Police in Saskatchewan were quick to send out mobile phone alerts to residents shortly after they realised that a mass attack was taking place.

Over the last few days, loud emergency phone alerts with updates on the manhunt became commonplace.

These types of alerts are usually sent for missing children or extreme weather events.

People I spoke to here were on the fence about the alerts and their frequency.

Some felt they were useful information that helped residents to remain cautious and aware. Others thought it was added stress amid the terrible news.

But this response suggested that the RCMP - the Royal Canadian Mounted Police - had shifted public communication tactics in the wake of another killing spree in Canada.

In Nova Scotia, a maritime province on Canada's east coast, a commission is looking into the police response to a mass shooting when a gunman, posing as a police officer, killed 22 people over the course of two days in April 2020.

One of the main issues being looked into at the inquiry? Why the force failed to use the provincial alert system to warn people of the danger.

The assistant commissioner continues that police have conducted more than 120 interviews so far in connection with the case as they try to piece together what happened.

Asked about the suspect's Myles Sanderson's brother, who was discovered dead on Monday, police say they are not prepared yet to say how he died.

"We may not know how some things unfolded," she says.

Blackmore says it remains unclear how Damien died, and "how that unfolded between the two of them".

Asked about the suspect's possible motive, the RCMP assistant commissioner says his motivation "may at this time and forever just be known to Myles".

Image source, Reuters

Police are now taking questions from journalists in Regina, and have refused to give more detail as to how Sanderson died.

"He was the only occupant of the vehicle when he was arrested," says the RCMP assistant commissioner.

"Shortly after being arrested he went into medical distress," she says, repeating her earlier statement. She says a post-mortem examination will determine how he died.

"I can't speak to the specific manner of death", she says, saying how he died is part of the ongoing investigation.

Police are now repeating their statement in French, one of Canada's two official languages alongside English.

The Saskatchewan RCMP chief adds that she visited the affected communities today, and personally witnessed the "generosity and support" of the residents there.

She adds her appreciation to all the police officers involved in the search, which took place over an area about half the size of Europe.

Police spotted the white truck that he had stolen, and after stopping him, "through verbal identification, confirmed the driver to Myles Sanderson," says Assistant Commissioner Blackmore.

"He was arrested by police and taken into custody. A knife was discovered inside his vehicle," she says.

"Shortly after his arrest he went into medical distress," she continued without describing how he died.

Image source, Getty Images

Police have confirmed that Myles Sanderson died shortly after he was arrested earlier on Wednesday, after going into "medical distress".

"This evening our province is breathing a collective sigh of relief as Myles Sanderson is no longer at large," says Assistant Commissioner Blackmore, beginning her statement.

She is now going through a timeline of the police response.

Police first arrived at the James Smith Cree Nation at 06:18 on Sunday, she says.

"The magnitude of this investigation is immense," she continues.

The Royal Canadian Mounted Police (RCMP) are now giving an update from the Mounties' regional headquarters in Regina, the capital of Saskatchewan.

RCMP Assistant Commissioner Rhonda Blackmore, who leads the Saskatchewan RCMP, will be speaking.

Many questions remain unanswered, including how people were stabbed across two communities in a short space of time, and why police failed to track down Myles Sanderson when he ceased contact with his parole officer.

Police say they have will only permit journalists to ask question for 20 minutes after making a statement.