Napoli have never won a major European match against Barcelona (D2 L2), while they’ve previously faced them in the round of 16 of the UEFA Champions League in 2019-20, losing 4-2 on aggregate.

Barcelona won 4-2 in their last meeting with Napoli, in the play-off round of the 2021-22 UEFA Europa League. This was the joint-most goals a team have scored in a European away game against the Italian side, with Manchester City being the only other team to have netted four (also a 4-2 win, in November 2017).

Barcelona are winless in their last three UEFA Champions League games against Italian opponents (D1 L2), losing as many of those three games as in their previous 19 games against Italian teams (W11 D6 L2).

Napoli manager Walter Mazzarri is unbeaten in his five UEFA Champions League home games (W4 D1), winning each of the last three. This will be just the third match he’s overseen in the knockout stages of the competition, with the previous two coming in the last 16 in 2011-12 (lost 5-4 on aggregate against Chelsea).

Barcelona have only won one of their last 10 away games in the knockout stages of the UEFA Champions League (D4 L5), with that victory coming against Manchester United in April 2019 (1-0). They’ve only scored four goals across these 10 matches, failing to score at all in six of them.

In this season’s UEFA Champions League group stage, Manchester City (44%) were the only side who had a higher percentage of their pressures come in the final third than Barcelona (42%). Indeed, Xavi’s side also ranked fourth for final third pressures per game in the group stage (147), despite them having the third-highest possession average (62%).

Napoli’s 10 goals in the UEFA Champions League this season have been netted by eight different players, while only Manchester City (9) had more different scorers in this season’s group stage.

Barcelona’s Robert Lewandowski hasn’t scored in any of his last four UEFA Champions League appearances – only once previously has he had a longer run of games without a goal in the competition, going five without netting between March and May 2018 for Bayern Munich.

Barcelona youngster Lamine Yamal – who has already netted in three different competitions for the club (LaLiga, Copa del Rey, Supercopa) – could become the first 16-year-old to score in the UEFA Champions League.

Ilkay Gündogan made the most passes that broke the opposition’s defensive line (14) in the group stage of this season’s UEFA Champions League. Meanwhile, only Jude Bellingham (6) created more chances from a line-breaking pass than Gündogan (5) in the group stage this term.