For Southern Brave, overseas player Devon Conway isn't playing because he has broken his finger, and is replaced by Paul Stirling.
For Manchester Originals, Sam Hain is brought in to strengthen the batting and spinner Matt Parkinson misses out.
The teams
BBC Sport/ECBCopyright: BBC Sport/ECB
BBC Sport/ECBCopyright: BBC Sport/ECB
Southern Brave win the toss and bowl
Captain James Vince calls correctly and puts Manchester Originals in to bat first.
Apparently there's a bit more rain due in an hour, so no surprises with that decision - we said the same with the women's fixture that if you're going to come on and off the pitch, it's harder for the batters to refocus after a disruption.
Post update
We were due to have the toss at 19:15, but it's been delayed a little longer because they're waiting for team sheets. Apparently they need them before they can do an official coin toss.
I'm sure it won't be long and we can give you toss and team news.
Post update
As we wait for news from the toss, you can also check out who are the key players in The Hundred so far, with the updated Most Valuable Player (MVP) rankings.
Post update
So where do these two teams stand at the moment?
Manchester Originals are in third and Southern Brave down in seventh - but the latter have won two on the bounce including a thriller against London Spirit in their last outing, so it seems as if things are just starting to click for this star-studded side.
Match to start at 19:45 BST
And it is good news!
If there's no more rain, the toss is going to take place at 19.15 with play to start at 19.45, and it will be 90 balls a side.
Post update
While we wait for (hopefully good) news from Old Trafford, why not catch up on the action from the earlier women's fixture, where Manchester Originals got their first win of The Hundred against the previously unbeaten Southern Brave?
The minimum amount needed for a game is 25 balls a side, and the latest play can start is 21:12 BST.
Toss delayed by rain
Welcome back!
We now have the men's fixture between Manchester Originals and the Southern Brave, but unfortunately the rain that ended the women's game early has meant that the toss has been delayed.
However, it's not currently raining and the covers are starting to be taken off, so fingers crossed we'll get some action.
Live Reporting
Ffion Wynne
All times stated are UK
Post update
For Southern Brave, overseas player Devon Conway isn't playing because he has broken his finger, and is replaced by Paul Stirling.
For Manchester Originals, Sam Hain is brought in to strengthen the batting and spinner Matt Parkinson misses out.
The teams
Southern Brave win the toss and bowl
Captain James Vince calls correctly and puts Manchester Originals in to bat first.
Apparently there's a bit more rain due in an hour, so no surprises with that decision - we said the same with the women's fixture that if you're going to come on and off the pitch, it's harder for the batters to refocus after a disruption.
Post update
We were due to have the toss at 19:15, but it's been delayed a little longer because they're waiting for team sheets. Apparently they need them before they can do an official coin toss.
I'm sure it won't be long and we can give you toss and team news.
Post update
As we wait for news from the toss, you can also check out who are the key players in The Hundred so far, with the updated Most Valuable Player (MVP) rankings.
Post update
So where do these two teams stand at the moment?
Manchester Originals are in third and Southern Brave down in seventh - but the latter have won two on the bounce including a thriller against London Spirit in their last outing, so it seems as if things are just starting to click for this star-studded side.
Match to start at 19:45 BST
And it is good news!
If there's no more rain, the toss is going to take place at 19.15 with play to start at 19.45, and it will be 90 balls a side.
Post update
While we wait for (hopefully good) news from Old Trafford, why not catch up on the action from the earlier women's fixture, where Manchester Originals got their first win of The Hundred against the previously unbeaten Southern Brave?
You can read Callum Matthews' report here.
Post update
The minimum amount needed for a game is 25 balls a side, and the latest play can start is 21:12 BST.
Toss delayed by rain
Welcome back!
We now have the men's fixture between Manchester Originals and the Southern Brave, but unfortunately the rain that ended the women's game early has meant that the toss has been delayed.
However, it's not currently raining and the covers are starting to be taken off, so fingers crossed we'll get some action.