West Ham make 11 changes from the first leg draw, with Sunday's Premier League trip to Arsenal in mind. Boss Slaven Bilic names three debutants - Doniel Henry, Kyle Knoyle and Manuel Lanzini. They will be guided by the expereince of skipper Kevin Nolan. Modiba Maiga starts up front. 

West Ham XI : Randolph, Knoyle, Jenkinson, Henry, Page, Poyet, Nolan, Cullen, Lanzini, Lee, Maiga.

Astra Giurgiu XI:  Lung, Alves, Seto, Enache, Budescu, Morais, Boldrin, Gaman, Teixeira, Queiros, De Amorim.

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Will we also be seeing a little something from Jay Rodriguez? 

The 26-year-old scored a cracker as Saints drew 1-1 with Spanish club Espanyol at the weekend, in what was his first appearance since suffering a knee ligament injury 16 months ago.

Come on in the second half if Ronald Koeman's side are already home and hosed? 

Southampton subs: K. Davis, Cedric, Rodriguez, Reed, Juanmi, Targett, McQueen.  

Think you know your football? Test your expertise by playing our game and seeing how many results you can predict correctly ahead of the opening weekend of the Premier League season.

Southampton manager Ronald Koeman hands debuts to defenders  Steven Caulker and  Cuco Martina in three changes from the first-leg 3-0 win last week. 

James Ward-Prowse comes in for injured midfielder Jordy Clasie, while Cedric Soares and Matt Targett make way. 

Vitesse XI:  Room, Diks, Kashia, Van der Werff, Leerdam, Baker, Nakamba, Vako, Brown, Rashica

Southampton XI:  Stekelenburg, Caulker, Fonte, Yoshida, Martina, Wanyama, Davis, Ward-Prowse, Tadic, Mane, Pelle

It's taken West Ham nine long years to get back into Europe but they could be tumbling out before the Europa League properly gets under way...unless they do the business in Romania.

The Hammers were in the driving seat at Upton Park, leading 2-0 before James Collins's dismissal allowed Astra to secure a 2-2 draw.

Kick-off in Romania is 19:00 BST - the same time Southampton start their second leg away to Vitesse in Arnhem protecting a 3-0 lead.

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"This is the beginning of a new adventure. We know the reward for winning the competition is a place in the Champions League and that is the ­ultimate dream." 

So said West Ham co-chairman David Gold upon hearing the Hammers would be playing competitive European action for the first time in nine years after qualifying through the Premier League Fair Play table.

But just five games in and the dream is threatening to turn into a nightmare, with manager Slaven Bilic in the firing line, West Ham's discipline under scrutiny and European lightweights Astra Giurgiu threatening an upset.

Can an under-strength Hammers team save the club from embarrassment in Romania?