Bournemouth beat Palace 11-10 in epic shootout
Grealish & debutant Watkins help Villa to 3-1 win at Burton
Fraser nets debut winner for Newcastle v Blackburn
Haller double as West Ham beat Charlton 3-0
Luton win 1-0 at Reading and will face Man Utd next
Barnsley beat Middlesbrough 2-0 to set up Chelsea tie
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Middlesbrough 0-2 Barnsley
Barnsley are eager to kill off this tie.
Marcus Bettinelli, who is on loan from Fulham, makes a fine save to deny Patrick Schmidt a second goal.
Around 20 minutes of normal time remaining.
Newport 0-0 Cambridge
Newport's Ryan Haynes is found in space in the middle from the corner but fires it over the bar.
Fleetwood 1-0 Port Vale
What a chance!
Danny Whitehead slips it through to Alex Hurst, who puts it on a plate for Theo Robinson. He drags it wide.
Reading 0-1 Luton
James Bree is enjoying himself. So much space on the right. He's whipping balls in for fun!
Matt Smith (62 mins)
The former Oldham and Fulham targetman is still doing the business - Matt Smith touches in a ball across the area.
Gillingham 0-0 Coventry
Coventry continue to dominate possession but League One Gillingham are at their stubborn best.
We're around 35 minutes away from penalties.
Newport 0-0 Cambridge
Still goalless at Newport.
Harvey Knibbs has just had a chance for Cambridge but it's off target from close range. Decent chance! They have had more of the ball in the opposition box so far.
Reading 0-1 Luton
Good spell from Luton, who are still putting pressure on Reading and look the more likely to score.
James Bree gets away on the right and picks out a teammate in the box but the header is always rising.
Paddy Madden
Paddy Madden is on hand to steer it in from inside the box after a decent cut-back from Ched Evans on the right.
It takes a big deflection off a defender, wrong-foots the keeper and rolls into the bottom right corner.
Newport 0-0 Cambridge
Decent effort by Cambridge's Harvey Knibbs.
He finds space outside the box but just sends his effort wide of the post.
Oxford 0-0 Watford
It's all happening.
Now Stipe Perica has just hit the crossbar with a header.
That's two chances for Watford's debutant who is having an eventful game.
Reading 0-1 Luton
Another decent chance for Luton but it comes from Reading defender Tom McIntyre, who almost slices a dangerous, low cross into his own net.
Wasn't far away that...
Oxford 0-0 Watford
Oxford free-kick but Rob Hall drives it high out of the ground and into the empty car park.
Fleetwood 0-0 Port Vale
No clear-cut chances yet but Port Vale keeper Dino Visser has been busy. He comes out to collect a cross from Paul Coutts.
Middlesbrough 0-2 Barnsley
Neil Warnock is not happy!
Paddy McNair is on at the start of the second-half for Anfernee Dijksteel.
Will Middlesbrough get back in this?
Burton Albion v Aston Villa (19:45 BST)
Villa's club record £28m signing Ollie Watkins will make his debut as the Premier League side get their season started at League One Midlands side Burton Albion.
Skipper Jack Grealish, fresh from signing his new five-year deal with the club earlier in the day, also starts in a strong Villa line-up, whilke young midfielder Jacob Ramsey makes his first start.
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Reading 0-1 Luton
Back underway at the Madejski, where Luton are looking to book in a tie with Manchester United in the third round.
Work to do for Reading.
Connor Mahoney (49 mins)
It's two! Connor Mahoney arrives on to a dinked cross to thump into the roof of the net.
Millwall will host Burnley or Sheffield United should they see this one out.
Leyton Orient v Plymouth Argyle (19:45 BST)
A home tie against Tottenham Hotspur is the prize for the winners of this tie.
Louis Dennis and Jobi McAnuff return as just three Orient players - Lawrence Vigeroux, Josh Coulson and Lee Angol - keep their places from the side that were 1-0 winners at Oldham on Saturday.
Meanwhile Argyle make four changes as Ryan Hardie, Dom Telford Byron Moore and Panutche Camara get the nod from boss Ryan Lowe.
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Anthony Scully (6 mins)
Incredible start! Lincoln, who will host Liverpool if they win this, double their lead as Anthony Scully is free to tap in at the back post.