Postpublished at 22:30 British Summer Time 26 October 2021
Arsenal, Chelsea and Sunderland made it through.
Have a read of all the reports and reaction
Who will join them on Wednesday? Come back here to find out.
Until then.
Chambers & Nketiah earn Arsenal 2-0 win v Leeds
Chelsea beat Southampton 4-3 on penalties after 1-1 draw
Sunderland into last eight with shootout win at QPR after 0-0 draw
Quarter-final draw takes place on Saturday
Shamoon Hafez, Gary Rose and Emlyn Begley
Arsenal, Chelsea and Sunderland made it through.
Have a read of all the reports and reaction
Who will join them on Wednesday? Come back here to find out.
Until then.
The quarter-final draw will take place live on Soccer AM on Sky Sports this Saturday from 10:30 BST.
Hosts Fenners and Jimmy Bullard will be conducting the draw.
Arsenal 2-0 Leeds
Leeds United
Leeds boss Marcelo Bielsa on Sky Sports: "The first half we had a tendency we couldn't continue in the second half and this made it difficult. When you go on and miss chances, it always gives the feeling to the opponent they can alter the result themselves.
"When you are behind it increases the problems, those are aspects a good team needs to overcome."
Arsenal 2-0 Leeds
Arsenal
Arsenal boss Mikel Arteta, speaking to Sky Sports: “A really good performance over a team where the manager in every action is so committed.
“We understood the game and what we had to do, we did this the right way.
“They gave us some issues, they always do, but we created a lot of shots and situations without being very clinical, we adjusted a few things at half time and we were better and stronger.”
On Ben White: “With Ben and with some others, he had a bug, so he wasn’t feeling great.
“We had some strong individual performances. They deserved the opportunity and grabbed it. We have hunger and desire and players willing to work, we need to carry on with this run and win more matches.”
Chelsea 1-1 Southampton (4-3 pens)
The Blues boys are happy.
Arsenal 2-0 Leeds
Arsenal
Arsenal defender Calum Chambers, who scored 23 seconds after coming on. tells Sky Sports: "It was good, it was a nice moment, I was pretty confident it went over so I was just waiting for him to give it!
"He (Mikel Arteta) told us to keep going, play the way we want, it's always hard against Leeds, they play in a very unique way, we stood up to the test and came away with the win."
QPR 1-1 Sunderland (1-3 pens)
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Steve: Fantastic result for Sunderland beating QPR 3-1 on penalties - quarter finalists in the League Cub!
Arsenal 2-0 Leeds
Arsenal
Arsenal goalscorer Eddie Nketiah on Sky Sports: "It's always nice to play, it's been a while, I have been working hard, waiting for my opportunity. The most important thing was to get through.
"We are on a good run at the moment, we push each other every day in training and results come in a match, the manager picks the 11 and ultimately we just work hard in training."
Chelsea 1-1 Southampton (4-3 pens)
Glenn Murray
Former Brighton striker on BBC Radio 5 live sports extra
It gets its complaints the EFL Cup, but this was one of the best games I have seen for a long, long time.
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Matt: Proud of the way Saints fought back tonight. But strange choice of penalty takers, why Walcott and Smallbone got the nod over Adam Armstrong makes no sense!
Chet: Penalties are the cruellest of ways to determine the winner. Feel for the Saints.
Arsenal 2-0 Leeds
Lee Dixon
Former Arsenal and England defender on BBC Radio 5 Live
Not a lot of footballers are able to win a trophy in their careers.
You've got to take the opportunities when they come. If you get a chance to have a run in any cup, you take it with both hands.
Chelsea 1-1 Southampton (4-3 pens)
That winning feeling.
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Dan: I apologise to all Blues fans. Listened to 90mins on the radio. Turned off for pens. We never win when I listen on radio. Sorry for the drama!
QPR 1-1 Sunderland (1-3 pens)
Yoann Barbet skies his penalty and Sunderland are into the quarter-finals!
Chelsea 1-1 Southampton (4-3 pens)
Glenn Murray
Former Brighton striker on BBC Radio 5 live sports extra
It was an absolutely brilliant cup tie, and it was excellent with the penalties at the end.
Reece James was calmness personified at the end.
Chelsea 1-1 Southampton (4-3 pens)
Chelsea
Oriol Romeu has to score... and he does but then Reece James scores and Chelsea go through!
QPR 1-1 Sunderland (1-3 pens)
QPR finally score a penalty, with Lyndon Dykes netting, and Alex Pritchard makes it three from three for Sunderland.
Chelsea 1-1 Southampton (3-2 on pens)
Glenn Murray
Former Brighton striker on BBC Radio 5 live sports extra
Poor, poor penalty from Smallbone. He leant back and up and over it went.
Chelsea 1-1 Southampton (3-2 pens)
Will Smallbone sends over the crossbar! A second miss of the night for Southampton.
Ben Chilwell then converts his spot kick and Chelsea lead!