Betis' Abner leaves his arm in the face of Jules Kounde and is booked.

That's now two 16-year-olds, an 18-year-old and two 20-year-olds on the pitch for Barcelona.

Barcelona bring on Fermin Lopez for Pedri.

Big chance for the Catalan visitors as Brazilian teenger Vitor Roque volleys wide from 12 yards.

Barcelona's Ferran Torres, like Isco looking for a hat-trick, shoots over from outside the box.

Isco has scored his first double in La Liga since 1 October 2017, in Real Madrid's 2-0 win over Espanyol.

The last Betis player to score multiple goals against Barca in a La Liga match was Ruben Castro on 20 August 2016. They lost that one 6-2.

Barcelona striker Vitor Roque is picked out in space in the box but his first touch is poor, and it turns out he's offside anyway.

It's a completely different game now and Real Betis' Johnny Cardoso shoots over from 25 yards.

Isco had failed to score in any of his previous 18 league games with Barcelona.

Wow. Isco drops back to just outside his own box to win the ball off Lamine Yamal and play a wonderful crossfield ball to a team-mate.

It's fair to say he's rediscovered his mojo here. The home fans chant his name.

Four of Barcelona's players on the pitch are younger than Pedri, 21, now.

Robert Lewandowksi, who is failing to hit the heights of last season, is replaced up front by Barcelona teenager Vitor Roque.

Isco was a boyhood Barcelona fan, despite spending the most successful years of his career with Real Madrid.

Image source, Get

The paperwork had not quite been completed in time for midfielder Jordan Henderson to make his Ajax debut today following his move from the Saudi Pro League.

But the 33-year-old was at the Johan Cruyff Arena to watch his team-mates clinch a 4-1 win over RKC Waalwijk.

Former Liverpool captain Henderson could make his Eredivisie debut away to Heracles Almelo next Saturday.

Video Assistant Refereepublished at 18:51 Greenwich Mean Time 21 January

18:51 GMT 21 January

Real Betis 1-2 Barcelona

They're checking this actually...

Isco thinks he's equalised but the flag goes up!

He runs onto a ball over the top and brilliantly dinks the ball over Inaki Pena despite the ball being up in the air. But it's disallowed.

It's mad to think Isco didn't have a club for the second half of last season. He's been brilliant for Real Betis since joining them in the summer.

Unhappy Barcelona players suround the referee - they think there was a foul earlier in the move - and Frenkie de Jong is booked.