Caley Thistle boss Duncan Ferguson is forced into two changes following last weekend's disappointing home defeat by Queen's Park.
In come on-loan Wigan Athletic centre-half James Carragher and Everton midfielder Sean McAllister, who makes his first start.
The experienced Danny Devine drops out and in-form on-loan Ross County forward Alex Samuel, who broke a hand last weekend, is only fit enough for the bench.
Ferguson had also planned to start Luis Longstaff, but the midfielder was stretchered off in training and is also missing.
Hibs head coach Nick Montgomery makes three changes from the side that lost out to a late penalty to Celtic in midweek.
On-loan Sunderland forward Eliezer Mayenda and former Queens Park Rangers midfielder Luke Amos are handed first starts, while Myziane Maolida, on loan from Hertha Berlin, also comes in.
The Dylans, Levitt and Vente, drop to the bench along with Elie Youan.
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Eliezer Mayenda is on loan to Hibs from SunderlandImage caption: Eliezer Mayenda is on loan to Hibs from Sunderland
Neil Warnock opts to make five changes following Tuesday night's defeat to Rangers.
Ross Doohan starts in goal ahead of first-choice shot-stopper Kelle Roos, with Angus MacDonald filling in at centre-back for Stefan Gartenmann.
Dante Polvara replaces Connor Barron in midfield, while Shayden Morris and Duk return in attack - with Jonny Hayes and Jamie McGrath dropping to the bench.
Robbie Horn makes two changes from Rose's League Two victory over Elgin City on Tuesday.
New arrivals Scott Mercer and Declan Byrne drop out of the XI and fail to make the bench. Callum Connolly and Smart Osadolor start in their absence.
Will we see a shock today?
Leanne Crichton discusses today's ties and where we could see an upset.
Video content
Video caption: 'I'm intrigued by Inverness against Hibs''I'm intrigued by Inverness against Hibs'
Live Reporting
Nick McPheat
All times stated are UK
First starts for McAllister, Mayenda & Amos
Inverness CT v Hibernian (15:00)
Caley Thistle boss Duncan Ferguson is forced into two changes following last weekend's disappointing home defeat by Queen's Park.
In come on-loan Wigan Athletic centre-half James Carragher and Everton midfielder Sean McAllister, who makes his first start.
The experienced Danny Devine drops out and in-form on-loan Ross County forward Alex Samuel, who broke a hand last weekend, is only fit enough for the bench.
Ferguson had also planned to start Luis Longstaff, but the midfielder was stretchered off in training and is also missing.
Hibs head coach Nick Montgomery makes three changes from the side that lost out to a late penalty to Celtic in midweek.
On-loan Sunderland forward Eliezer Mayenda and former Queens Park Rangers midfielder Luke Amos are handed first starts, while Myziane Maolida, on loan from Hertha Berlin, also comes in.
The Dylans, Levitt and Vente, drop to the bench along with Elie Youan.
LINE-UPS from Caledonian Stadium
Inverness CT v Hibernian (15:00)
Inverness CT: Ridgers, Harper, Carragher, Mullen, Kerr, Shaw, Gilmour, Anderson, McAllister, Savage, Mckay.
Substitutes: Pepple, Doran, Samuels, MacGregor, Boyes, Mackay, Brooks, Ujdur.
Hibernian: Marshall, Miller, Fish, Triantis, Obita, Amos, Newell, Moriah-Welsh Boyle, Mayenda, Maolida.
Substitutes: Wollacott, Hanlon, Levitt, Youan, Vente, Cadden, Stevenson, La Fondre, Emiliano.
Five changes for Dons; Rose switch two
Aberdeen v Bonnyrigg Rose (15:00)
Neil Warnock opts to make five changes following Tuesday night's defeat to Rangers.
Ross Doohan starts in goal ahead of first-choice shot-stopper Kelle Roos, with Angus MacDonald filling in at centre-back for Stefan Gartenmann.
Dante Polvara replaces Connor Barron in midfield, while Shayden Morris and Duk return in attack - with Jonny Hayes and Jamie McGrath dropping to the bench.
Robbie Horn makes two changes from Rose's League Two victory over Elgin City on Tuesday.
New arrivals Scott Mercer and Declan Byrne drop out of the XI and fail to make the bench. Callum Connolly and Smart Osadolor start in their absence.
Will we see a shock today?
Leanne Crichton discusses today's ties and where we could see an upset.
Video content
LINE-UPS from Pittodrie
Aberdeen v Bonnyrigg Rose (15:00)
Aberdeen: Doohan, Devlin, MacDonald, Jensen, MacKenzie, Shinnie, Clarkson, Polvara, Morris, Miovski, Duk.
Substitutes: Roos, Gartenmann, McGrath, Barron, Hayes, Phillips, Sokler, Duncan, Milne.
Bonnyrigg Rose: Martin, Mailer, Young, Martyniuk, Peggie, Connolly, Doan, Currie, Gray, Osadolor, Barrett.
Substitutes: Andrews, McGale, Stewart, Jarvis, Watson, McGachie, Wardell.
Graham returns for Thistle; Nouble in for Livingston
Partick Thistle v Livingston (15:00)
Two changes for Partick Thistle, with academy graduate Ben Stanway back in the team to replace the injured Scott Robinson.
Tomi Adeloye also drops to the bench, despite his goalscoring exploits against Airdrieonians. Captain Brian Graham comes in to replace him.
For Livingston, David Carson is cup-tied while Steven Bradley drops to the bench.
Striker Joel Nouble is in from the start, as is midfielder Stephen Kelly.
LINE-UPS from Rugby Park
Kilmarnock v Cove Rangers (15:00)
Kilmarnock: Dennis, Ndaba, Mayo, Findlay, Kennedy, McKenzie, Watson, Polworth, Murray, Watkins, Van Veen.
Substitutes: O'Hara, Wright, Donnelly, Balagizi, Armstrong, Mackay-Steven, Stewart, Vassell, Cameron.
Cove Rangers: Suman, Doyle, Scully, Darge, Reynolds, Niang, Gillingham, Yule, Kerr, Burrell, Megginson.
Substitutes: Demus, Jones, McGowan, Connell, Stewart.
LINE-UPS from Firhill
Partick Thistle v Livingston (15:00)
Partick Thistle: Sneddon, McMillan, Muirhead, Neilson, Milne, McInroy, Bannigan, Stanway, Fitzpatrick, Graham, Lawless.
Substitutes: Stewart, Mitchell, Williams, Ngwenya, Alston, Lyon, MacKenzie, Diack, Adeloye.
Livingston: McGovern, Donnellan, Obileye, Nottingham, Brandon, Holt, Pittman, St Kelly, MacKay, Nouble, Yengi.
Substitutes: George, Anderson, Bradley, Sangare, Shinnie, Se Kelly, Ledingham, Culbert, Lawal.
Post update
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Saturday's last-16 ties
All 15:00 kick-offs unless stated
🏆 Scottish Cup Saturdays
One down, seven to play.
Scottish Cup last-16 weekend got off to a flyer last night - and that was only a starter.
We're treated to five tasty ties today, will we see any more shocks?
You're in the right place to find oot.