It leaves Warriors 13 points adrift of leaders Leinster, while Ospreys move up to 11th thanks to a first away win in Glasgow for nine years.
Warriors, what went wrong? What do you make of the manner of the defeat?
Image source, SNSClovers kept up the pressure on compatriots Wolfhounds at the top of the Celtic Challenge with an 10-try win over Edinburgh.
Emily Lane got the scoring underway early at the Hive Stadium, although Lucia Scott's penalty quickly cut the deficit.
However, the Clovers had their bonus point try within the first twenty minutes with quickfire scores from captain Amee Leigh Costigan, Shirley Bailey, and Lane.
Edinburgh responded through vice-captain Hannah Walker, with the winger going over in the corner.
Clovers reasserted their dominance before half-time, getting their fifth and six tries before the break with winger Anna McGann getting both on either side of the pitch.
Although they lead 36-8 at half-time, the Clovers did not rest on their laurels and continued their try-scoring in the second-half.
Substitute Enya Breen got their seventh, Jemima Adams Verling got the eighth and Saoirse Crowe got the ninth from short-range.
Hannah Ramsay did a consolation try for the hosts, but there was still time for McGann to wrap up her hat-trick with a breakaway intercept try.
Edinburgh didn't go quietly, and Giselle Chicot scored in the final play from a move started by Scotland star Alex Stewart. However, they remain fourth in the table with just two wins from this year's tournament.
Edinburgh: Scott, Bell, Brown, Chicot, Walker; Ramsay, Clarke; Wilson, Ronald, Poolman, Ferrie, Logan, Moody, Stewart (c), Gunderson.
Replacements: Craig, Tawake, Brown, Russell, Sutherland, Benson, Denholm, Love.
Clovers: Finn, Costigan (c), Corey, Flannery, McGann; Fowley, Lane; Burke, Gavin, Barrett, Campbell, O'Flynn, Verling, Oviawe, Bailey.
Replacements: Buttimer, Crowe, Burns, Neill, Quinn, Reilly, Breen, Ugwueru.
Image source, SNSBrython Thunder climbed above Glasgow Warriors in the Celtic Challenge standings as they won 33-17 at Scotstoun.
The Welsh visitors raced into a 14-0 lead thanks to a double from Welsh international Gwen Crabb, both being converted by Niamh Terry.
Briar McNamara got one back for the hosts, converting her own try, before Ellie Tromans extended Thunder's lead just before the break. Hannah Marshall added the extras, that time.
Glasgow were the first to strike in the second half through former Scotland winger Abi Evans but the visitors asserted their dominance on the scoreline through Rosie Carr.
Roma Fraser's phenomenal solo try threatened to set up a tense finale as Glasgow got within nine points, but again the Thunder would find a response.
A few penalties marched them up the pitch and with the final set-piece of the game, Crabb crashed over for her hat-trick.
The result gives Thunder just their second win of the tournament - their other win coming against Edinburgh - while Glasgow remain rooted to the bottom of the rankings.
Glasgow Warriors: Mellanby, Evans, Flynn, McNamara, Proctor; Ainsworth, McDonald (c); Fletcher, Hyland, Fleming, Zameer, Yeomans, Walker, MacGilvray, Coubrough.
Replacements: Sutcliffe, Tucker, Ward, Sinclair, Price, Darroch, Warren, Fraser.
Brython Thunder: Lane, Tromans, Bluck, Healan, Hing; Terry, Singleton; Orin, Gant, C Davies, R Davies, Crabb, Mugabe, Isaac, Rogers (c).
Replacements: R Carr, Williams, K Carr, Jones, Stowell, Adkins, Marshall, F Davies.
Edinburgh fans, we asked for your opinions on the surprise 34-28 win over Munster in Cork.
Here's a taste of what you had to say:
Alan: Been here before. I'll believe Edinburgh have turned a corner when they put in three or four decent performances in a row.
Ross: Where has this attack and power been all season? Munster may have had a poor night out but Edinburgh dominated everything. Imagine the amount of tries Duhan and Darcy would score for fun if the scrum performed that well week in, week out.
David: A remarkable turnaround which makes the Zebre game even more annoying. But, typical of Edinburgh to dampen it all by letting Munster take two losing bonus points. That rather took the shine off that win.
Steve: Good and unexpected result, so fair play to the lads. However, there still appears to be a lack of intelligence in respect of game management. Why, when we already had the try bonus point, kick for the corner from a penalty? Munster were 13 points behind and the penalty was kickable. It's basic stuff still not being done well enough.
Arran: That was a lot better from Edinburgh. Yes, they were playing an inexperienced Munster side that gifted them two tries, but you take what you can get in rugby. Magnus Bradbury and Ben Muncaster were excellent, same with Ben Vellacott and Matt Currie. This type of performance has to be the standard from now on if we want to make the play-offs.
Kenny: A more than welcome win for Edinburgh against a poor Munster outfit. Getting a consistently reliable fly half is a priority though, as Ross Thompson is just not cutting it for me.
Edinburgh fans, what did you make of your side's performance in Cork as they bounced back from successive league defeats by Scarlets and Zebre?
Who stood out for you and are you now confident of a play-off spot?
Image source, Getty ImagesEdinburgh head coach Sean Everitt tells Premier Sports: "Very pleased. We had to go back to the drawing board when you lose at home.
"Our set-piece functioned really well which allowed us to put pressure on them from a field position point of view, and I thought we were outstanding defensively tonight.
"We learned hard lessons against Zebre. Top four is probably a little bit ambitious, but certainly top eight.
"We don't often win away from home so this was a really good confidence builder for the team."
Image source, SNSAdam Hastings has been out injured with a fractured jaw
Scotland international Adam Hastings will make his return from injury when Glasgow host Ospreys in the URC on Saturday.
The versatile back fractured his jaw playing against Scarlets in the autumn, and has missed the Six Nations as a result.
Hastings, 28, is named at full-back with Duncan Weir captaining the side from fly-half. Ben Afshar returns to the team at scrum-half, while Ollie Smith partners Duncan Munn in the centres.
Jare Oguntibeju - who signed his first professional contract with the club this week - starts in the second row, and JP du Preez could make his first appearance in 650 days having been selected among the replacements.
Defending champions Glasgow are second in the URC table, 10 points behind league-leaders Leinster.
Glasgow side to face Ospreys: Hastings, Cancelliere, Smith, Munn, Cordero, Weir, Afshar; Schickerling, Stewart, Richardson, Oguntibeju, Samuel, Ferrie, Venter, Mann.
Replacements: Matthews, McBeth, Talakai, Du Preez, Miller, Fraser, Kennedy, Johnston.
Tom English
BBC Scotland's chief sports writer
At Twickenham on Saturday, Scotland went a full hour without scoring, from minute 19 to minute 79 when they almost snatched victory from the jaws of defeat.
Against Ireland in round two it took them 41 minutes to register their first points while also going scoreless for 26 minutes later in the game. In the Six Nations opener against Italy they scored their third try in the 28th minute and didn't score again until the 61st.
Going without points for such long periods in Six Nations games is not new for Scotland, but it's part of why they're running to stand still - or maybe even sliding backwards depending on what happens in the final two weekends.
Last season they didn't score after the 42nd minute against Wales (fine, they won, just about), didn't score for nearly 50 minutes against Italy (not fine, they lost) and went an hour without a score against Ireland in Dublin in a four-point match, which they also lost.
In 2023, they went vast chunks of time without scoring in defeats to France and Ireland. In 2022 they didn't score in the last 30 in a narrow loss in Cardiff, didn't score for 50 against France and didn't score for 33 and then 45 minutes against Ireland.
Apologies for the overload in numbers (more coming) but they're there to illustrate this is not new.
The subject of Scotland's attack came up on this week's BBC Scotland Rugby Podcast. In this championship, only France score the type of blistering tries that Scotland score, the one-phase wonders, the strikes from deep that have the stamp of genius upon them.
Scotland got three more of them at Twickenham, not that they provided any solace in the aftermath. The debate that should be had now centres around Scotland's one-track mind for the tryline and how they need to change their thinking.
It's in their DNA to turn down opportunities to kick for goal - drop-goals and penalties. They are all-in on attack. It's what makes them thrilling and deeply frustrating.
In 10 entries to England's 22 on Saturday they came away with zero points. Rugby is a game of psychology and pressure as much as anything else. Every repelled Scotland attack gave England belief.
It's past time that Scotland wisened up to their reality and brought an element of pragmatism and scoreboard pressure to their game.
In all those entries, what harm if they accepted once or twice that England's defence was strong, dropped into the pocket and took a drop goal, if they could? Get out of there with something instead of nothing.
Scotland miss late kick to win as England hold on to win Calcutta Cup
Scotland, more than most, should do it because their breakdown has struggled (only France have conceded more turnovers) and their handling errors are the highest in the championship.
A bit of nous is required, some leadership, a voice to say, 'You know what, we're 10-7 ahead (as they were against England), this attack is petering out, we might lose the ball, so let's try a drop goal to make it 13-7 and 16-7 and put the pressure on them'.
It's easy to look aghast at the statistics from Twickenham and wonder how Scotland contrived to lose that game. Three tries to one in the visitors' favour was just the start of it.
More possession and territory than England, nearly seven more attacking minutes, more than double the number of ball carries, more than three times the number of defenders beaten, more than four times the number of linebreaks.
These are stats to make a Scot weep, but they're a familiar story. There was nothing unusual about them at all.
In the loss to Ireland, Scotland had 57% possession, they had 20.3 attacking minutes to Ireland's 15.2, they had more carries, more metres gained, more defenders beaten.
Ireland had to make more tackles, missed more tackles, conceded more penalties and lost four lineouts to Scotland's one. And yet they won easily because they were more powerful, more canny and more ruthless.
In last season's controversial four-point loss to France at Murrayfield, Scotland were ahead on nearly all of the stats - 21.9 attacking minutes versus 17.9 for the away winners.
The defeat to Italy in Rome showed similar trends. Scotland were ahead in loads of metrics. Italy had 17 attacking minutes, Scotland had 25.
We could go back to previous seasons and find Six Nations-wrecking losses that told the same story. Nobody wants Scotland to remove the ambition from their game. With this backline, you couldn't even if you tried. But there's an imbalance in the way they score and it's destructive.
Instead of a default set of going for touch from kickable penalty range, there are times when going for the posts is the sensible play.
With six minutes to go at Twickenham, Scotland had a penalty from very makeable range, even though Russell was off form with the placed ball. They went for touch, lost the lineout and exited with nothing.
Three points then would have made it 16-13. Given the outrageous skill-set in this Scotland backline, they'd have fancied their chances to score a winning try from that position. Wise after the event? Not really. They scored a late try to win at Twickenham two years ago.
And, of course, they scored late again on Saturday, but it wasn't enough this time, not when the conversion (from the incorrect spot, thanks to the referee) flew wide.
They wouldn't have needed it had some pragmatism entered their thinking in that 74th minute and in many of the attacking minutes that went before it.
Image source, SNSBen Vellacott is back in the Edinburgh starting line-up
Sean Everitt has changed seven of his starting XV for the trip to Munster on Friday night after a humiliating defeat to Zebre left Edinburgh's URC play-off hopes hanging by a thread.
The South African head coach is boosted for the Cork visit by the return of co-captain Ben Vellacott and number eight Magnus Bradbury.
The only other change in the backline sees James Lang come in. However, as Emiliano Boffelli misses out with a hamstring problem, Matt Currie moves on to the wing.
In the forwards, Ewan Ashman is released from Scotland duty to start at hooker. He has come off the bench in every Six Nations match so far.
Paul Hill comes in at tighthead prop, Sam Skinner is into the second row, and Ben Muncaster joins Bradbury in the back row after a few weeks out with injury.
Ali Price drops to the bench, while Ben Healy misses out with a hip complaint. Cammy Scott takes up his spot among the replacements and could make just a second appearance of the season.
Dave Cherry, Grant Gilchrist, Darcy Graham, Jamie Ritchie, Pierre Schoeman and Duhan van der Merwe are all retained by the national team.
Edinburgh: Goosen, M Currie, Lang, Tuipulotu, McCann; Thompson, Vellacott (c); Venter, Ashman, Hill, Sykes, Skinner, Crosbie, Muncaster, Bradbury.
Replacements: Harrison, Hislop, Rae, Young, Watson, Price, C Scott, Bennett.
Image source, SNSGlasgow second-row Jare Oguntibeju has continued his incredible rise in professional rugby by committing his future to Scotstoun club, penning his first pro contract.
The 22-year-old has impressed hugely on his four outings so far, scoring against Toulon in the Champion Cup, having only joined the club on a pro contract in the summer.
Born in South Africa, the 6ft 8ins lock spent his childhood in Edinburgh and had a trial spell at the capital club before joining Ealing Trailfinders.
After picking up a bad knee injury playing for Scotland's Under-20s, he made his return playing in the Super Series for Stirling Wolves.
Before making his Glasgow bow, he also picked up a Scotland A cap in the game against Chile in November.
"I'm very grateful for the chance," Oguntibeju told club media. "I didn't expect it all to happen so soon after arriving, but I'm really proud to have the chance to represent this club.
"I've really enjoyed it – I didn't expect to play as much as I have, but I've been blessed with the opportunity and Franco and the coaches have shown great trust in me this season so far.
"Positionally, all the second-rowers have been huge for me, whether that's someone like Scott [Cummings] with my defence or Max [Williamson] with lineout detail. Guys like Henco [Venter], the Fagersons, the whole pack, too – it's like a real family group."
BBC Scotland's chief sportswriter Tom English has been answering some of your Scottish rugby questions.
James asked: For a number of years the Scotland U20 team have been destroyed in the Six Nations. This year is maybe the worst. What is going wrong? How worried should we be for the future of the Scotland team? Is there a way to address this?
Tom answered: That's why David Nucifora is here as performance director. He's been given what seems like total power to reimagine the player pathway system from about the age of 15.
I hope he's serious about his business - he flies in and out of his native Australia - because the pathway system has let down years and years worth of young players.
They say the first step in solving a problem is accepting you have a problem. The SRU know their underage system is largely not fit for purpose. Hence, Nucifora.
Young players need a more professional set-up - better coaching, better strength and conditioning, more meaningful games. I think a lot of the Scottish U-20s in recent years have been badly let down.
David G asked: After losing the pivotal match against England - a game they should have won - are you now concerned Scotland's morale will be low and a revitalised Wales can win? How does Gregor Townsend lift Finn Russell and the players for this game?
Tom answered: I don't think morale will be low. Sadly, Scotland have been in this place before and have managed to bounce back, even though the bounce came too late to contend for a championship.
The Wales game has a whole different look now. It was an odds-on win before for Scotland, but the Welsh performance against Ireland was an eye-opener. Yes, it was driven by emotion and desperation, but that only partly explains why they were so good.
It explains the thunder of their forwards but the quality of their attack was on a different planet to anything we have seen from them in over a year. A new coaching voice who has put players in their natural positions did wonders against Ireland.
The question remains about Wales' ability to replicate that away from home. I still make Scotland favourites - they're hardly lacking in motivation themselves - but I suspect this will be closer than it might have been before Warren Gatland left. I think Scotland will win.
Grant asked: Considering how many foreign imports Ireland have in their 23, why does it seems only Scotland get flak for their so-called 'plastic players'?
Tom answered: Ireland get less grief for their 'foreign' players probably because they win things.
Not much is made of it, you're right. I guess when you win then you get to write the narrative. Bundee Aki, James Lowe, Jamison Gibson-Park, Mack Hansen, Finlay Bealham have all played an enormous part in Ireland's success.
'The referee bottled it' - Lawson on try call
Former captain Rory Lawson joins Tom English and Andy Burke to analyse Scotland's agonising Six Nations defeat by England and preview the upcoming game with Wales.
Image source, SNSScotland have followed victory over Italy with defeats by Ireland and England
Former captain John Barclay is predicting a nervous atmosphere at Murrayfield a week on Saturday when Scotland take on Wales in the Six Nations.
After the tightest of losses to England, Scotland's best chance of a second win comes at home to resurgent Wales, as they finish with a trip to Paris to play in-form France.
"[Scotland v Wales] looks a bit different now, it's going to be tighter than we thought," Barclay told the Rugby Union Daily podcast. "From first two Wales games, there was no sign of anything to be concerned about.
"You watch the game at the weekend when they go toe to toe, physically and tactically, with one of the best teams in the world [Ireland]. Is it the bounce effect? I don't know, we'll see next weekend."
Wales, with interim head coach Matt Sherratt taking charge for the first time, looked far stronger in the defeat to Ireland than in previous losses to France and Italy.
"If Scotland lose to Wales, you're looking at one from five because they've got to go away to France," Barclay added.
"They've won over in France, they've shown it can be done, but you don't want to be going into the last round of the Six Nations with one win.
"The pressure is firmly on Scotland. Everyone says Scotland deserved to win [against England], but they didn't win and they didn't win against Ireland. Quite plainly, they have to win.
"It will be a nervous energy around the stadium. Wales are still underdogs, it's going to be fascinating."
Gregor Townsend has come under pressure in some quarters, but Barclay defended the Scotland head coach.
"There is pressure, there's always pressure. Someone said to me the other day 'he's got to go' and I'm like 'well who are you replacing him with?' Franco [Smith] has done great things at Glasgow, what's the guarantee that he gets better?
"You look at the game at the weekend, Gregor Townsend has done his job. He's put in place clearly how they were trying to play the game and they did it, except for final passes. I don't think that's a coaching thing."
Andy Burke
BBC Sport Scotland Senior Reporter
Image source, SNSFinn flak unfair
As one of Scotland's few genuine global superstars, Finn Russell's performances are subject to a level of scrutiny reserved for only the top players.
When Scotland win, often the headlines speak to a Russell masterclass, even if his display has featured good moments and bad.
When Scotland lose, the fly-half, the team's chief creative force, is invariably a lightning rod for fierce criticism.
Russell missed the game-defining conversion from Duhan van der Merwe's 79th minute try, a tough kick, but one that he would expect to nail more times than not.
The missed conversion after Ben White's try was a far bigger error, but the focus on the three missed kicks, and the suggestion that Russell cost Scotland victory, has unfairly coloured reviews of the Bath man's performance.
He was instrumental in Scotland's attack cutting England open time and again in the first half, and the blame can't be laid at his door for the fumbles and sloppy breakdown work that prevented the Scots from converting the chances that would have put England away.
Scotland started losing the physical battle after the break and even the best 10s will struggle to guide their team to victory when their ball-carriers are being knocked backwards.
Those missed kicks were crucial, no question, but to suggest Russell had a poor game is wide of the mark, and those dismissing his credentials to be the Lions fly-half this summer off the back of it are overlooking, or forgetting, his quality.
Put Russell behind a Lions pack beside a Sione Tuipulotu or Bundee Aki and watch him shine.
Referee calls in the spotlight again
Speaking of that game-defining conversion, Russell's kick would have been easier had it been taken from the right mark.
As Russell lined up his kick, referee Pierre Brousset ordered him to move his tee two metres wide of the line where Van der Merwe touched down. It was an inexplicable decision in a crucial moment, and with the shot clock running, there was no time for Russell to argue the point.
The Television Match Officials seem very keen to involve themselves in Test matches these days, so why is Brousset not getting some help? A word in the ear to say," Pierre, the original tee position was just fine".
Several calls from Brousset had the Scotland fans up in arms, some justifiably so, some not. What is clear is match officials are too often having too big an influence on Test matches.
No referee should have to put up with personal abuse. The sport needs them. However, like players and coaches, their performances should be analysed in the proper way, and it felt like Brousset and his support team got a few calls wrong.
Another Six Nations slips away
It's wearily familiar territory for Scottish fans to be sitting after round three with their Six Nations dreams already down the pan.
In truth, the hopes of a promising campaign started to unravel the moment captain Sione Tuipulotu, such a totemic figure in this Scotland team, was ruled out of the tournament through injury before the opening round.
The injuries have piled up since and the Scottish squad depth, despite improving in recent years, has been exposed as too shallow to cope with five rounds of Six Nations battles.
For Gregor Townsend, the questions return about his ability to break this team through to the next level, namely being in the title hunt at the business end of the tournament.
After eight cracks at it, many feel he has taken the team as far as he can. Others feel with his limited resources and crippling injury list this time around, the head coach is being harshly judged against the expectations he has helped to create.
Former Scotland captain John Barclay told the BBC's Rugby Union Podcast he feels Townsend's position should not be under threat, but admitted that if Scotland lose to Wales in round four and are left staring at a campaign of one win from five, it may be time for a different conversation.
Scotland agonisingly missed out on another Calcutta Cup victory after a narrow Twickenham defeat.
Gregor Townsend's side now face another free weekend before facing Wales, at Murrayfield, on Saturday 8 March.
With that in mind, have you got any burning questions to put to our rugby writers Tom English and Andy Burke? Send them in via this link, external, and they will be answered on this page later in the week.
Thomas Duncan
BBC Sport Scotland
Image source, SNSSecond row Grant Gilchrist says it "hurts" for Scotland to be out of Six Nations title contention after round three following the one-point defeat by England.
A bruising loss to Ireland and the loss at Twickenham leaves Scotland on one win from three games, with Wales to come at Murrayfield before a final weekend visit to play France.
"We came here to win because we knew we'd put ourselves in a position where we needed to win," Gilchrist told BBC Scotland.
"But we have to focus on that level of performance - it is going to win us more games than it loses us.
"We have to now look at winning our last two games and where that will leave us in the Championship. Depending on other results, that's where we're at.
"Obviously, it hurts to be saying that. I want to be standing here going: 'We have two games and we've got a chance to win the Championship.'
"But we weren't quite good enough."
After Wales put up a strong fight before eventually going down to grand-slam chasing Ireland, Gilchrist expects a rejuvenated side to arrive at Murrayfield on 8 March, regardless of their run of 15 straight defeats.
"Six Nations games are so tough - every game is a proper test match now," Gilchrist added.
"If you're not at your very best, you don't win.
"Wales will be taking a lot of positives from their game and they'll be coming up to Murrayfield to win.
"For us, it has to be another step forward in our performance levels.
"I believe if we add another layer to what we put on [against England], we win the game next week and we go to Paris - looking to add a bit more on again and win there."
