Theresa May urges MPs to back a "good deal" for the UK while reminding them of their duty to voters.

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Independent MP Charlie Elphicke says the Home Office should prioritise county lines operations in tackling drugs.

Mrs May says there needs to be proper integration of work between the National Crime Agency and local police forces. The government recognises this is a growing problem and is taking action, she says.

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Labour MP Chris Bryant raises the "hidden epidemic" of acquired brain injury, and asks for the PM, "and I do mean her", to meet with him and other campaigners on the issue.

"We can save lives, we can give people better quality of lives, we just need to join the dots up."

Mrs May says the honorable gentleman "rightly speaks with passion" on the issue, and says "it is one I will ensure he brings information appropriately to ministers".

She ministers working together is vital.

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Conservative MP Heidi Allen asks about sleeping shifts, and says in the absence of clarity some companies are paying a through the night rate for night workers rather than the national minimum wage.

She says this issue needs to be tackled as soon as possible.

Theresa May acknowledges this issue has been raised by MPs on numerous occasions, and stresses that the secretary of state for health and social care is looking at this issue.

"We will have to consider any outcome that comes out of the current related Supreme Court reading," she says.

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Labour's Emma Dent Coad asks for Islamophobia in the Conservative Party to be investigated, following requests from the Muslim Council of Britain.

Mrs May says every complaint that has been made is being investigated and the party is suspending people where necessary.

"There should be no place in this country for discrimination," she states.

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Conservative MP Alex Burghart asks the prime minister if she agrees that it would be wonderful if the Uk could join up with Japan in a trade deal post Brexit.

Earlier this week, Japan's prime minister said Britain would be welcomed into the Trans-Pacific Partnership trade deal with "open arms" after it leaves the EU.

The TPP is a trade agreement between 11 countries, including Japan, Canada, Australia and Malaysia.

Theresa May says she has spoken to Japan's prime minister about this issue, and is pleased Japan want to accept the UK with open arms and looks forward to working with them on future deals.

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Independent MP Kelvin Hopkins says environmental warnings this week show that "radical transport reforms are vital for our future".

He asks for the PM to express her personal support for "proposed GB freight route rail scheme, which would take some five million lorry journeys off our roads each year."

Theresa May says Mr Hopkins makes an important point, and the government is investing more money into the strategic freight network, but she'll have to look into the specific point he has raised.

"The principle of encouraging freight onto rail and off our roads is a good one."

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Conservative Rebecca Pow asks a question on the Agriculture Bill this afternoon, which she says will allow the UK to take another look at how farmers operate.

Mrs May says that this is the case, and that the UK will work on biodiversity and sustainability in the environment.

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Conservative MP James Gray says 120 soldiers will march into Parliament today to be thanked by MPs and peers for their participation in operations such as Operation Tangham, which saw British soldiers training and supporting the Somali Army.

He asks if the prime minister will join him in paying tribute to these soldiers, their families, those who returned back with mental and physical injuries, and those who never returned.

Theresa May says she is "proud of our servicemen and women and everything they say and do, and the government will be proud to embrace them."

"We should also recognise the importance of supporting those who return with physical and mental injuries, and we should never forget those who have laid down their lives for this country."

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Labour MP Ronnie Campbell says that after the financial crisis national debt "stood at £768 billion". He asks what level the debt is at now.

Theresa May says Mr Campbell "doesn't need me to answer the question if he's got the figure in front of him".

She says the government has reduced the deficit "by three quarters".

"The gentlemen shouldn't look so pleased with himself," she says, suggesting debt would be far worse under a Labour government.

Read more about the UK's debt and deficit here

Reality check: How big is the UK's deficit and debt?

Mark D'Arcy
Parliamentary Correspondent

Ken Clarke cuts through the verbiage and delivers a deadly summary of the PM’s Brexit difficulties – culminating in an appeal for her to enlist Labour MPs to vote for a soft Brexit deal – and outface her own hard Brexiteers – or right wing nationalists as he called them.

Quite how helpful the PM found his intervention is an open question.

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Conservative Ken Clarke says the biggest task this winter is to secure agreement with the 27 other EU leaders on the withdrawal from the EU, followed by Parliament agreeing on the terms.

He says that "maths make it obvious" that the agreement can only pass if it gets support from moderate pro-EU MPs, rather than the anti-EU Labour front bench and pro-Brexit Conservative MPs.

Mrs May says the UK is "working for that deal" and she hopes that everybody will put the "national interest first". She adds that it is "our duty to ensure that we leave".

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Labour MP Jim McMahon says that modern slavery remains a "scourge on our society", and commends the Co-op group for creating paid work placements to help victims improve their lives.

He asks the prime minister why it has taken five months to review the anti-slavery post, and says more needs to be done to combat modern slavery.

Theresa May says modern slavery is an issue which she has a particular interest in, and that she is pleased the Modern Slavery Act is having a positive impact.

"Slavery is still happening, we still need to do more," she says.

"I congratulate businesses like the Co-op for all they are doing to help victims of modern slavery get back into work."

Analysis by Mark D'Arcy

Labour rising star Jim McMahon calls for action to toughen up the Modern Slavery Act – as Home Secretary Theresa May was instrumental in pushing it through, but there are rising complaints that it is not being enforced effectively.

There was a Westminster Hall debate on Tuesday where these concerns were raised, and some action was promised.

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Lib Dem Alistair Carmichael says Scottish fishermen are lobbying the government today, asking for an assurance that the prime minister "will not trade away the right to fish in UK waters".

Ms May says that government has always been clear that after Brexit, EU fishing rules no longer apply to the United Kingdom.

The UK will be an independent coastal state, and "will be seeking to gain a fairer share".