The line-up selected was the most Thomas Tuchel had experimented with a starting XI since he officially took charge of England on 1 January.
Debutant Jarell Quansah was just the seventh player to get a first cap under Tuchel across his 10 matches in charge.
The England manager has made a point of giving clarity to his players about who they are directly up against for a place in the team and this side, apart from the strong spine, showed who Tuchel currently sees as the number twos in their respective positions.
Jude Bellingham was making his first start for England since June following a shoulder injury. In his absence, Morgan Rogers' impressive performances have seen an intriguing battle develop for the England number 10 role.
But again, it was Tuchel's tactical acumen and his well-timed substitutions that saw England get another win in this impressive World Cup qualifying campaign.
Against Serbia, it was Eberechi Eze and Phil Foden who combined off the bench to score England's second goal and this time it was Saka and Rashford who teed up Kane for his two goals.
England have missed out in recent major tournaments by fine margins and former manager Gareth Southgate was criticised for at times not making changes when some thought England needed them.
Tuchel has already shown in his club career that he can make decisions at crucial moments to win trophies and with England he is changing games with the array of attacking talent at his disposal from the bench.