It was a horrible opening 45 minutes from England and when the half-time whistle went, having conceded three goals, captain Leah Williamson was hurrying her team-mates down the tunnel.
The centre-back had been in intense conversations with manager Wiegman, and fellow defenders Millie Bright and Niamh Charles, prior to Mead's penalty as they attempted to address their glaring issues.
Belgium were relentlessly direct, pinging balls over the top and exploiting space left in behind - and England failed to respond.
Goalkeeper Hannah Hampton - who has nudged ahead in the battle for the number one spot - could do very little about any of the goals her side conceded.
Wullaert was given a free run on goal for the opener and was a few yards out when the cross came in for her second, after Vanhaevermaet's brilliant header had looped over Hampton.
The sight of Wullaert on the teamsheet was an unwelcome one for England as she was missed by Belgium in their defeat on Friday, and made an instant impact on her return from injury in Leuven.
Wiegman had to respond and she did not waste time, hooking defenders Charles and Bright off at half-time, and bringing on Agyemang, Fran Kirby and Ella Toone to add more attacking threat later on.
It did have an impact as Toone came close when she sent an effort just past the far post, after Williamson's long-range effort had been tipped over the bar.
Agyemang's introduction was miraculous and she played with confidence for the final 10 minutes, but Belgium did enough to hold on to their lead.
"It's disappointing for her. She was great, came in and did really well. I thought she scored an incredible goal," added Wiegman.
"The composure she had and the calmness... It was really incredible. We do have to celebrate that a little bit for her."
It became scrappy and tense as England threw everything at the hosts - referee Maria Sole Ferrieri Caputi handing out seven yellow cards in total - and the crowd became more raucous.
But while there were significant improvements for England in the last half-hour, this performance fell well below expectations and they cannot afford to be so sloppy in Switzerland this summer.