This leading pair are both brilliant time trial riders.

Van Vleuten is the reigning world time trial champion - but what has the Giro Rosa taken out of her?

Van der Breggen is holding her advantage.

Olympic champion Anna van der Breggen has a gap of eight seconds over compatriot Annemiek van Vleuten on the descent.

Ashleigh Moolman Pasio looks to be too far behind to make it back.

Anna van der Breggen dominated the spring - winning Strade Bianche, the Tour of Flanders, La Fleche Wallonne and Liege-Bastogne-Liege.

She takes the summit of the Col de la Colombiere solo - can she hold this gap on the descent?

Annemiek van Vleuten is a hitter - the defending champion grinds her way back up towards her compatriot.

Ashleigh Moolman Pasio follows several seconds down - can they catch the leader on this descent?

Ashleigh Moolman Pasio is riding tempo, trying to limit her losses to the Dutch pair up the road.

Annemiek van Vleuten is six seconds down on her compatriot Anna van der Breggen.

Van der Breggen needs as much time as possible over the top, with Van Vleuten the world time trial champion.

She has 500m to go to the summit.

Van Vleuten now just needs to hold this gap and try to make it up on the descent.

Van der Breggen has 800m until the summit of the Col de la Colombiere.

Anna van der Breggen looks the strongest of these three - Ashleigh Moolman Pasio drops off the wheel and Annemiek van Vleuten looks in pain, grinding her way up the climb to stay in touch.

Anna van der Breggen puts in a dig and makes the catch of Cecilie Uttrup Ludwig.

And Ashleigh Moolman Pasio uses that to launch an attack of her own.

Ludwig will have to dig deep to try and get herself to the top with minimal losses.

Cecilie Uttrup Ludwig has a gap of just 11 seconds now.

Can she keep with the trio coming up behind to help out her team-mate Ashleigh Moolman Pasio?

Defending champion Annemiek van Vleuten clearly has carried her form from the Giro Rosa.

The Dutchwoman puts in another dig, forcing Ashleigh Moolman Pasio and Anna van der Breggen to up the tempo and follow.

Sure enough, Lucinda Brand is dropped, unable to stick with the pace of the favourites.

Ludwig is next in their sights, about 40 seconds up the road.

The elite trio of Anna van der Breggen, Ashleigh Moolman Pasio and defending champion Annemiek van Vleuten have caught Lucinda Brand.

Can Brand hang on? Surely the next attack from this group will see her dropped.

Van der Breggen, Moolman Pasio and Van Vleuten are close to catching Brand.

Ludwig has a lead of 55 seconds over them.

Moolman Pasio latches onto the wheel of Van Vleuten and Van der Breggen. That elite trio have distanced the peloton.

They still have Brand and Ludwig out front to catch.

Moolman Pasio has a free ride and won't have to contribute to the chase, with her Cervelo-Bigla team-mate Ludwig out front.

Garcia is caught and Anna van der Breggen goes.

Fellow favourite Annemiek van Vleuten follows.

Niewiadoma is dropped, with other riders in trouble.

Again Spratt goes, with Moolman Pasio on her wheel. These surges will start spitting riders out the back.

Cecilie Uttrup Ludwig drives on, with 5.5km to go of this climb and still holding an advantage of 1'24'' over the chasing peloton.

Margarita Garcia now attacks out of the bunch to close down the Dane.

The peloton can't leave Ludwig out there too long. The first attack comes from Amanda Spratt, bringing Ashleigh Moolman Pasio, Margarita Garcia and Anna van der Breggen with her.

Annemiek van Vleuten settles in and rides up to them, bringing the rest of the main group with her.

Ludwig is off the descent and onto the lower slopes of the Col de la Colombiere.

It's a first category climb - 7.5km at an average 8.5% gradient.

Lucinda Brand has caught and passed Leah Thomas on the descent and is now the second rider on the road.

Lucinda Brand is flying down this descent and has gained a few seconds on the peloton.

There is a descent to finish this race into Le Grand-Bornand after the final climb, which will be decisive.