Costa heads 50th Premier League goal and then fires in low
Romeu and Bertrand score against former club
Hazard buries from 15 yards, Cahill heads home
Terry makes first league appearance since November
Chelsea v Southampton is not the only big game tonight. Huddersfield can clinch a place in the Championship play-offs if they win away to mid-table Wolves - also a 19:45 BST kick-off.
In League One, Port Vale will be down if they lose at Walsall.
Follow all tonight's EFL action in a dedicated live text here.
Image source, Rex Features"How much do you want for Paul Pogba? Take it all"
Spending the most money on players does not guarantee Premier League success, says Chelsea manager Antonio Conte.
The Italian cited both Manchester clubs after United spent a world-record £89m on midfielder Paul Pogba and Man City spent £47.5m on defender John Stones.
Leaders Chelsea have an 11-point lead over City and 12 points over United with six games remaining.
"It's important to understand it's not always who spends more wins," he said.
"This season isn't the only season both Manchester clubs have spent a lot of money. Look at the past."
Jonathan Pearce
BBC Sport
This is huge. If Chelsea follow up their FA Cup semi-final win with an emphatic victory they'll hold their nerve and land the title.
But this is a slippery one. They've found Southampton troublesome at home and the Saints have had 10 days to prepare.
A defeat for the league leaders will open the door for Spurs.
Chelsea were far too open in the thrilling semi-final. They also haven't gone this long without a league clean sheet in nearly 21 years.
Southampton may not have beaten a current top-six side all season but they've looked dangerous away recently. Tricky this for the leaders!
BBC Three
How much does Chelsea keeper Asmir Begovic know about the club? He's put to the test with a Blues-themed quiz hosted by Gary Lineker.
On his lift to work, the 6ft 7in Bosnia-Herzegovina international also reveals which team-mate he wouldn't like to share a room with and he attempts to topple Dele Alli in the Paddlefoot Challenge.
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Phil McNulty
BBC Sport chief football writer at Stamford Bridge
Polite applause for John Terry as he comes out to warm up. Chelsea's captain, who has made 713 appearances for the club, is leaving at the end of this season and there are only three games left at Stamford Bridge after this one before he makes his farewell.
Southampton looking remarkably relaxed in their warm-up. Sounds of laughter booming into the stands from their players.
Spoiler alert: No, he can't
It is game number three of Tony Adams' La Liga managerial career tonight. His Granada side are at home to Malaga.
They are seven points adrift of safety with five games to go so it would be a good time to pick up his first win.
They have not won in eight matches, and have lost Adams' two opening matches - 3-0 and 2-0.
That kicks off at 19:30 BST.
Image source, Getty Imageson 81111
Image source, PAHow about the Matthew Le Tissier Zinger Tower Stadium. Honouring Saints' love for the man and his love for a certain fast food chain.
Nick, Winchester
Mark Hopkins on Twitter:How about The Le God Arena?
Name a more iconic trio. I'll wait.
Chelsea v Southampton (19:45 BST)
Mark Lawrenson
BBC football expert
Image source, BBC SportDo you think Chelsea will win 10-0? Southampton to win 7-5? Or something more realistic? Have your own go at predicting the score with our Premier League Predictor.
Phil McNulty
BBC Sport chief football writer at Stamford Bridge
When Chelsea lost their last Premier League game at Manchester United - which saw the lead at the top reduced to just four points from Spurs - there were suggestions that the nerves were starting to show on Antonio Conte's side.
The FA Cup semi-final win over Spurs at Wembley on Saturday answered those questions and provided a strong statement of intent.
And Chelsea can now turn the tables and put Spurs under pressure with victory over Southampton at Stamford Bridge tonight. It would give them a seven-point advantage ahead of Spurs' tough visit to in-form Crystal Palace tomorrow night.
#bbcfootball
Russell Edge: While we should never ever change the name of St James' Park again, if Rafa Benitez continues the #rafalution, Benitez Park?
Brayo: Apparently, the name Stamford Bridge is too fine. I would rename Cobham training ground Didier Drogba
Mitch: I think the most deserved name for a stadium based on current performance has to be Oxlade Arena. He's been our top player.
Adam Blackmore
BBC Radio Solent sports editor
Either Nathan Redmond's had one of his spats with Claude Puel or he's not trained because of injury. His partnership with Ryan Bertrand will be missed.
Chelsea's Eden Hazard, Diego Costa and Gary Cahill all return to the starting line-up. Hazard and Costa came on as substitutes in the 4-2 FA Cup semi-final win over Tottenham. Defender Cahill missed the tie because of gastroenteritis.
Image source, .Southampton make two changes from the side that lost 3-0 at home to Manchester City. Oriol Romeu returns after a two-game suspension and fellow midfielder Sofiane Boufal in the starting XI. Nathan Redmond and Pierre-Emile Hojbjerg make way.
Image source, .on 81111
In spite of the current situation, no naming could be more deserved than Emirates Stadium becoming the Arsène Wenger Stadium. What better way to celebrate a true legend of the club than naming the stadium he worked so hard to give us after him?
Jonny, Arsenal fan in Glasgow
on 81111
Solid start. The DDD.
Image source, PAI would put a roof on it and rename Old Trafford the Djemba-Djemba Dome
Dan from Andover
Chelsea's opponents today, Southampton, are the epitome of nothing to play for.
The Saints are ninth, 17 points below the Europa League places. They are only nine points above the bottom three, but with an eight-team buffer between them and the relegation zone (and some games in hand), I don't think they'll be worried.
Image source, Rex FeaturesSouthampton's players might as well just get themselves to the beach
Chelsea boss Antonio Conte brings Eden Hazard and Diego Costa back into his starting line-up as expected.
Full team news for the Blues and Southampton to follow.
#bbcfootball or text 81111
Ajax have announced that their Amsterdam Arena home is going to be renamed as the Johan Cruyff Arena.
The Dutchman, considered one of football's all-time greats, died last year at the age of 68.
He had two spells as an Ajax player, as well as managing them.
We want to know if you could name your team's ground after anybody who would it be? The Rodney Jack Stadium? The Claus Lundekvam Bowl?
Let us know using #bbcfootball, text us on 81111 or by commenting on the BBC Sport Facebook page.
Alan Shearer
Match of the Day pundit
Image source, .The way Chelsea beat Tottenham in Saturday's FA Cup semi-final showed why they are going to win the Premier League title too.
The Blues scored four goals against the team with the best defensive record in the top flight, so you cannot say they did not deserve their victory.
And anyone who doubted Chelsea after their defeats by Manchester United and Crystal Palace just had to watch them at Wembley to see how good they are.
This was a superb display that won a brilliant cup tie and, psychologically, could and probably should pull them across the line in the title race too.
They know they beat their closest rivals despite not having three key players for the majority of the game - centre-back Gary Cahill, who was out injured, and winger Eden Hazard and striker Diego Costa, who came off the bench with less than half an hour to play.
Image source, #bbcfootballIn fact Chelsea are getting so concerned about the charge of Spurs, who have won their last seven Premier League matches, that on Saturday, they left their two key attacking players on the bench for an FA Cup semi-final.
So they can focus on a league game against Southampton. That's how worried they are.
Admittedly both Eden Hazard and Diego Costa came on in the Wembley semi-final against their title rivals Spurs, and Chelsea won, but they played less than half an hour each.