Danny Ings flicks it on to Stuart Armstrong from the throw-in but his cross is blocked. Ings then gets a smack in the face when he tussles with Gabriel and gets a free-kick.

Off we go!

Predictions?

Send them in. Use #bbcfootball on Twitter.

Here come the players. James Ward-Prowse has the armband on for Southampton, while Hector Bellerín is captaining Arsenal today. A reminder of the teams:

Southampton XI: Forster, Walker-Peters, Bednarek, Stephens, Bertrand, Diallo, Ward-Prowse, Armstrong, Walcott, Ings, Adams.

Arsenal XI: Leno, Bellerin, Holding, Gabriel, Cedric, Elneny, Xhaka, Pepe, Willian, Martinelli, Nketiah.

BBC One

If you miss any of the action today, there's also a highlights show with Gary Lineker on BBC One from 22:20 GMT.

Southampton are winless in all of their FA Cup meetings with Arsenal (W0-D1-L4). Arsenal also defeated Southampton 1-0 in the 2002-03 FA Cup final.

Can they change that today?

Calum Chambers has been named on the bench for Arsenal, with manager Mikel Arteta confirming he has no intention to send the defender out on loan.

Chambers, who has returned to full fitness following a serious knee injury, has made just three appearances this season - two in the Europa League and once for the Under-21s side in the EFL Trophy.

Image source, Getty Images

"I don't think that is going to happen," Arteta said when asked if Chambers would be loaned out.

"I am really happy with Calum. He has gone through a really difficult period. He has worked so hard.

"He has looked really good in the last few weeks in training. He is not even thinking about his knee right now. We want to give him minutes when we can because he is a player that we believe in."

Barnsley will be without former Norwich striker Carlton Morris because he is cup tied.

The Reds have lost their past two league games and boss Valerien Ismael could make changes.

Norwich City boss Daniel Farke has confirmed midfielder Kenny McLean has tested positive for Covid-19 and will have to self-isolate.

Defender Christoph Zimmerman, midfielder Todd Cantwell and striker Teemu Pukki are all out injured.

The winner of the tie will host either Chelsea or Luton Town in the next round.

Arsenal

Arsenal manager Mikel Arteta to BT Sport: "We're in a much better place, winning matches and playing well. Today we play our favourite competition. We have to defend it because we are the winners but we have a difficult opponent.

"We have to change because there are players who deserve a chance and we have some injuries as well."

On Gabriel Martinelli: "He has been in and out. He has been really helpful when he has played. He has had a few niggles. He has back now and ready."

On Pierre-Emerick Aubameyang: "It is a personal matter in the last few hours so we have to send him back."

Southampton

Southampton manager Ralph Hassenhuttl to BT Sport: "I hope it is a strong side and we can compete with them! It is an important competition.

"Arsenal have a bigger squad and can change a little more. We are struggling with injuries but hopefully we can be strong.

"It is a different game [when they play Arsenal again next week] - I know it is not that long in between - but both are important for us."

On Danny Ings' return: "It is good he is back. You need to have physically good options."

Sulaimon: In recent years Arsenal hasn't had easy run of fixtures on the road to the final. Saint Mary's is another difficult ground but the gunners have enough quality to win and advance to the next round.

Arsenal defender Cedric Soares is up against his former club. He spent five years at Southampton.

West Ham United

Michail Antonio could start a third successive game for West Ham when they host Doncaster Rovers in the FA Cup fourth round on Saturday.

Antonio has scored in his past two appearances for the Hammers following his return from injury.

Teenage forward Mipo Odubeko has tested positive for Covid-19, leaving manager David Moyes' attacking options limited.

Doncaster midfielder AJ Greaves will miss out for the League One side because he is cup-tied.

The 20-year-old has recently broken into the Rovers team but played in the FA Cup for Northern Premier League side Gainsborough earlier in the season.

Brighton & Hove Albion

Brighton boss Graham Potter will continue to be without a host of first-team players as defender Tariq Lamptey remains sidelined with a hamstring injury.

Midfielder Adam Lallana is still out with a groin injury and forward Danny Welbeck continues to miss out due to a knee problem.

It seemed a good idea at the time, a chance to catch up with friends and relieve the anxiety that had been building after being frozen out at Newport County.

Ben Tozer had been labelled a "bad egg" and told to stay away from the League Two club after a disagreement with then-manager Graham Westley during a team meeting.

So when friends suggested a day out in nearby Cardiff to celebrate Tozer's birthday, the former Newcastle United player jumped at the opportunity to forget his problems for a few hours.

"We were in a pub and something happened. My mates didn't recognise my behaviour," recalls Tozer.

"I became embroiled in an argument with a stranger. That's not me. It was trivial but I was in a dark place because of everything that was going on."

Read more here.

Image source, Getty Images

Arsenal have tweeted, external.

Mikel Arteta says Aubayemang "had a personal matter in the last few hours and we had to send him back."

Best wishes to him.

Southampton have won just one of their last nine meetings with Arsenal in all competitions (D3 L5), a 3-2 league victory in December 2018.

Arsenal have been victorious in all four of their previous FA Cup ties against Southampton, going on to win the trophy on the last three occasions they've beaten Saints (1979, 2003, 2017).

Southampton have won just three of their last 17 FA Cup matches against Premier League opponents.

Arsenal have won 11 of their last 12 FA Cup away games, losing the other at Nottingham Forest in January 2018.

Southampton

Today's game is the first of two in four days between the two sides, with Southampton again hosting Arsenal in the Premier League on Tuesday, 26 January (20:15 GMT).

Saints boss Ralph Hasenhuttl said he has no intention of prioritising either game and has challenged his side to secure back-to-back wins.

Judging by his team selection today, he's kept his word. This is what he said earlier this week:

"I'd prefer winning both to be honest, if it's possible we'll do it, but I know it's tough.

"Yes, we have the chance to. On our day we can beat any team in the league, we've shown this, especially at home.

"I think this is the goal we have. Yes, tough like always, but not impossible."

It is a tale of two returning strikers in the early FA Cup game.

Southampton welcome back Danny Ings, who has now recovered from a hamstring injury and Covid to start. He is one of six changes from the Saints' last game - the third-round win over Shrewsbur.

The side is far closer to that often fielded in the Premier League, with Kyle Walker-Peters and Ryan Bertrand returning at full-back, Stuart Armstrong and Theo Walcott coming into midfield and Che Adams partnering Ings up top.

Southampton XI: Forster, Walker-Peters, Bednarek, Stephens, Bertrand, Diallo, Ward-Prowse, Armstrong, Walcott, Ings, Adams.

Gabriel Martinelli is back for Arsenal, hoping once again to put his injury woes behind him. He starts in attack with Eddie Nketiah in two of seven changes from the league win over Newcastle.

Gabriel and Hector Bellerin come into defence, Mohamed Elneny is in the centre of midfield, while Nicolas Pepe and Willian will aim to supply to ammunition for the the forwards.

Goalkeeper Mat Ryan, who joined on loan from Brighton this week, is on the bench.

Arsenal XI: Leno, Bellerin, Holding, Gabriel, Cedric, Elneny, Xhaka, Pepe, Willian, Martinelli, Nketiah.