Postpublished at 16:36 Greenwich Mean Time 8 January 2022
Newcastle 0-1 Cambridge
High fives all round as Jubril Okedina holds off Miguel Almiron to earn a goal kick for Cambridge!
Everton, Southampton and Plymouth through after extra time in day's late games
League One Cambridge Utd stun Newcastle - arguably day's biggest shock
National League North Kidderminster bridge four-division gap to beat Reading
National League Boreham Wood beat AFC Wimbledon
Championship side Huddersfield win 2-1 at Burnley
Every goal across the weekend available on BBC Sport app
Michael Emons, Gary Rose and Harry Poole
Newcastle 0-1 Cambridge
High fives all round as Jubril Okedina holds off Miguel Almiron to earn a goal kick for Cambridge!
Bryan Mbeumo (76 mins)
But that could be job done for Brentford!
A superb individual goal. Bryan Mbeumo gets his second goal in 14 minutes since coming on as a substitute - carrying the ball before whipping a finish into the corner - to punish Port Vale on the break. Just as the hosts were threatening to draw level, too.
Newcastle 0-1 Cambridge
Here's the moment Cambridge took the lead at St James' Park...
Port Vale 1-2 Brentford
Brentford need to be careful here. Port Vale believe they can get an equaliser here and so do the crowd. The League Two side are all over the visitors at the moment!
Chelsea v Chesterfield (17:30 GMT)
Phil McNulty
BBC Sport chief football writer at Stamford Bridge
Filthy weather at Stamford Bridge but the thousands of Chesterfield fans in and around the stadium are loving it.
Spirites' top scorer Kabongo Thsimanga is being celebrated loudly in song with a reworked version of Wham's "Wake Me Up Before You Go Go" stating "Wake Me Up Before You Go Go Who Needs Messi When We've Got Kabongo?"
Beautiful.
Boreham Wood 1-0 AFC Wimbledon
It is entering nail biting territory for Boreham Wood fans as their side lead with just under 20 minutes to go.
AFC Wimbledon are seeing plenty of the ball but the hosts are keeping them at bay.
QPR 0-0 Rotherham
Rotherham are yet to manage a shot on target in this one, but QPR haven't made any of their 11 attempts count yet. Around 15 minutes to go at Loftus Road.
Newcastle 0-1 Cambridge
Kieran Trippier curls a ball to the back post but Cambridge are getting a head to everything that comes into their penalty area. 15 minutes to go at St James'....
Leicester 3-1 Watford
Jason McAteer is on for Ayoze Perez as Leicester freshen things up. Watford make a double change too. That's all their substitutions used now.
Aynsley Pears own goal
A shock is on at the DW Stadium. Wigan were one down and now two one up.
There looks to be little danger with Jack Whatmough’s header but it is a disaster for away goalkeeper Aynsley Pears who fumbles the ball over the line for an own goal.
Wigan 1-1 Blackburn
Wigan so close to moving ahead. It’s a header from Jason Kerr, who gets there ahead of Blackburn goalkeeper Aynsley Pears, but the header bounces off the crossbar.
Newcastle 0-1 Cambridge
Brilliant. Adam May shapes to shoot on the edge of the box but the Cambridge man slips, Newcastle threaten to break so May throws his head and body towards the ball on the ground to make the tackle!
West Brom 1-0 Brighton
Another huge chance for Brighton.
Shane Duffy ends up firing over from a few yards out! They need to put one of these away, especially now West Brom are down to 10 men...
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Massive last 20 minutes for Newcastle. They have put out a strong team so obviously are not writing off the cup to concentrate on the league. I think a defeat would be a big confidence blow but if they can turn it around it could be just the boost they need.
Craig, Craster
Leicester 3-1 Watford
Off the bar! Watford's pressure starting to mount. Joao Pedro gets the cut-back but smacks it straight off the underside of the crossbar.
There might have been an offside in the build-up though.
Peterborough 2-1 Bristol Rovers
The Posh are looking to kill this game off. Sammie Szmodics has one goal already and nearly gets a second and Peterborough’s third but is denied by a fine save from James Belshaw.
Kian Harratt (70 mins)
Oh, hello!
Vale substitute Kian Harratt has pulled the hosts right back into this tie!
The 19-year-old, on his Vale debut, sends a great header past Jonas Lossl and Vale Park erupts! Game on.
Newcastle 0-1 Cambridge
Backs to the wall now for Cambridge. They have every player behind the ball in the box as Joe Willock is found in the area, firing into a horde of gold shirts.
West Brom 1-0 Brighton
Uh-oh. This could make things very interesting. West Brom's Cedric Kipre is off!
He's late on Alexis Mac Allister and gets a second yellow.
Sam Austin (69 mins)
The non league side are level!
Could they pull off an upset? Captain Sam Austin sees his shot squirm in under the goalkeeper and there's scenes of delight in the stands.
A deserved equaliser for the hosts and all to play for.