Postpublished at 90 mins
Cambridge Utd 0-3 Luton
The fourth official's board shows five minutes of injury time.
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Chelsea beat Chesterfield in round three, while Plymouth knocked out Birmingham
Tuchel tests positive for Covid and misses tie
Plymouth are seventh in League One
Chelsea are eight-team winners, last in 2017-18
Plymouth's best FA Cup run saw them reach the semi-finals in 1983-84
Phil Dawkes and Shamoon Hafez
Cambridge Utd 0-3 Luton
The fourth official's board shows five minutes of injury time.
Cambridge Utd 0-3 Luton
David James
Former England goalkeeper on BBC Red Button
I think this takes a deflection. The keeper had no chance.
Luton deserve this, but Cambridge will be so frustrated having had so many chances.
Admiral Muskwe
And that seals it!
Admiral Muskwe gets the ball on the right side of the box and he turns before bending a shot into the far corner with the help of a deflection.
Harsh on Cambridge, who have been very good in this half but Luton have been clinical.
Cambridge Utd 0-2 Luton
Luton make a double change to throw on some fresh legs for the final few minutes.
Amari'i Bell and Allan Campbell are on for Fred Onyedinma and Carlos Mendes Gomes.
Cambridge Utd 0-2 Luton
Cambridge almost have the goal their second half display deserves as Jed Steer gets down to push away Ben Worman's low strike.
Cambridge Utd 0-2 Luton
Cambridge are going long with time against them but you feel this Luton defence will clean up these high balls into the box all day long.
Tottenham v Brighton (20:00 GMT)
It’s five changes for Tottenham from the side that lost 2-0 to Chelsea 13 days ago.
Emerson Royal, Cristian Romero, Ben Davies, Sergio Reguilon and Lucas Moura all come in.
January signings Rodrigo Bentancur and Dejan Kulusevski are both on the bench.
Tottenham XI: Lloris, Royal, Romero, Sanchez, Davies, Reguilon, Winks, Hojberg, Lucas, Son, Kane.
Brighton captain Lewis Dunk starts for the first time since December 1 after recovering from a knee injury. He is one of five changes from the team that drew 1-1 with Leicester last time out on January 23.
Tariq Lamptey, Yves Bissouma, Adam Lallana and Solly March are also all given starts after missing out.
Brighton XI: Sanchez, Lamptey, Cucurella, Webster, Dunk, Bissouma, Maupay, Gross, Lallana, Moder, March.
Cambridge Utd 0-2 Luton
Jed Steer is almost caught out by a ball into the box, he pushes it away and the Luton defence clears before Lorent Tolaj can pounce.
Cambridge Utd 0-2 Luton
Luton make another change as Harry Cornick - who has eight goals this season- replaces veteran Cameron Jerome in attack.
Cambridge Utd 0-2 Luton
Cambridge are upping the pressure with Luton struggling to get out of their area but there's relief for the visitors as the home side's momentum is halted as the whistle goes for a foul inside the box.
Cambridge Utd 0-2 Luton
It is a triple change for Cambridge as Adam May, James Brophy and Harvey Knibbs are replaced by Ben Worman, Jack Lankester and Lorent Tolaj.
Cambridge Utd 0-2 Luton
Cambridge are on the attack but they can't find a way through the Luton defence as James Brophy sees his shot blocked.
There's a couple of changes about to be made by the home side.
Cambridge Utd 0-2 Luton
Luton make the first change of the game as Elliot Thorpe, after taking a few knocks in this game, is replaced by Danny Hylton.
The forward has history with Cambridge, having scored six goals against them including a hat-trick in a 7-0 win back in 2017.
Cambridge Utd 0-2 Luton
Wes Hoolahan's shot from the edge of the area is blocked as Cambridge attack. They need to get a goal soon if they are to have a chance of getting back into this.
Cambridge Utd 0-2 Luton
Elliot Thorpe just wants to keep playing. After a bit of treatment he is back on and good to go.
Cambridge Utd 0-2 Luton
Elliot Thorpe is down injured again after a clash. This might be a knock too far and Luton boss Nathan Jones sends a couple of his players out to warm up.
Cambridge Utd 0-2 Luton
... but the delivery from the set piece is over everyone. The wind is making things really unpredictable.
Cambridge Utd 0-2 Luton
Admiral Muskwe charges forward for Luton. It looks like he loses out in a battle with two Cambridge players but does manage to win a corner...
Cambridge Utd 0-2 Luton
Huge chance for Cambridge United to get back into this!
It is route one as James Brophy knocks a long ball down into Sam Smith's path but the striker hooks his effort wide.
He had to get it on target at least.
Cambridge Utd 0-2 Luton
Wes Hoolahan goes low with this free kick but it is comfortably cleared by Cameron Jerome.
A wasted opportunity.