Jadon Sancho tries to get in on the action early in his appearance but after turning his man in the box he drags his shot across goal and wide.

David Moyes makes six changes from the West Ham side that drew 1-1 against Aston Villa at the weekend.

In come Ben Johnson, Angelo Ogbonna, Aaron Cresswell, Pablo Fornals, Manuel Lanzini and Gianluca Scamacca.

Michail Antonio, who scored both goals in the 2-0 win in Cyprus, is not in the squad because of a calf injury.

West Ham XI: Areola, Cresswell, Ogbonna, Zouma, Johnson, Fornals, Soucek, Lanzini, Paqueta, Bowen, Scamacca.

Subs: Anang, Hegyi, Aguerd, Emerson, Potts, Kehrer, Benrahma, Rice, Laing, Cornet, Ings, Mubama.

There are three changes for AEK Larnaca from the first leg with Mikel Gonzalez, Giorgos Naoum and Nemanja Nikolic replacing Hrvoje Milicevic, Roberto Rosales and Rafael Lopes.

AEK Larnaca XI: Piric, Englezou, Tomovic, Gonzalez, Casas, Ledes, Mamas, Jakolis, Sanjurjo, Naoum, Nikolic.

Subs: Toumpas, Stylianidis, Gonzalez, Christoforou, Andreou, Milicevic, Faraj, Trickovski, Altman, Lopes, Rosales, Pons.

Changes for both sides.

Borja Iglesias, Sergio Canales and Willian Jose are on for the home side.

Shortly after, Marcus Rashford and Fred are taken off for Marcel Sabitzer and Jadon Sancho.

Erik ten Hag trusting that Casemiro and Bruno Fernandes are not going to get booked.

Rob Green
Former England goalkeeper on BBC Radio 5 Live

If anyone was going to settle it, it is Marcus Rashford. This Europa League ball shifts, it wobbles and moves.

Rashford puts his foot through it and the goalkeeper thinks it is coming right to him but it swerves into the corner.

The Betis fans were initially silences by that goal but then burst into applause. I can't imagine it was for Rashford's strike, more for the efforts of their players, which are now going to be in vain.

Rob Green
Former England goalkeeper on BBC Radio 5 Live

Massive chance, that would have killed the tie and it fell to the right person.

You just feel Bruno Fernandes held onto it just too long and it closed down the angle for Marcus Rashford.

And now David de Gea is called into action!

Ayoze Perez darts to the near post to flick a header on target from a corner but the United keeper is equal to it.

Huge chance to kill it!

United are away. It's four on three. Facundo Pellistri finds Bruno Fernandes and his pass gives Marcus Rashford just the keeper to beat. The form he has been in, you are just waiting for him to slot home, but RuiSilva comes out on top with a fine block.

Mikel Arteta makes five changes to the Arsenal side from their 3-0 win over Fulham in the Premier League.

Striker Gabriel Jesus returns to the starting XI after his substitute appearance on the weekend marked his return from injury.

Gabriel Martinelli remains alongside him in attack but Bukayo Saka is rested.

Martin Odegaard, Thomas Partey, Ben White and Leandro Trossard also drop to the bench.

Takehiro Tomiyasu, Jorginho, Reiss Nelson and Fabio Vieira start.

Arsenal XI: Ramsdale, Tomiyasu, Saliba, Gabriel, Zinchenko, Nelson, Jorginho, Xhaka, Vieira, Jesus, Martinelli.

Subs: Turner, Hillson, Tierney, White, Partey, Saka, Odegaard, Smith Rowe, Kiwior, Holding, Trossard.

There are two changes to the Sporting side who drew with Arsenal in the first leg.

Captain Sebastian Coates and Hidemasa Morita are suspended so in come Ousmane Diomande and Manuel Ugarte.

Former Tottenham forward Marcus Edwards starts for Sporting Lisbon again.

Sporting Lisbon XI: Adan, St Juste, Diomande, Inacio, Esgaio, Goncalves, Ugarte, Reis, Trincao, Paulinho, Edwards.

Subs: Israel, Alexandropoulos, Santos, Neto, Rochinha, Issahaku, Tanlongo, Gomes, Cabral, Chermiti, Mateus, Essugo.

Facundo Pellistri has been a willing runner but he's not seeing as much of the ball as he'd like. He is sent scurrying into Betis territory by a fine pass from Fred, but is crowded out before he can fire an effort at goal.

Marcus Rashford is fortunate when a sloppy pass bounces back to him, but the resulting effort he fires is off target. High and over the bar.

Aitor Ruibal hasn't brought his shooting boots with him. He goes for glory from range again but sends his angled effort well wide.

Rob Green
Former England goalkeeper on BBC Radio 5 Live

It has been uncomfortable for Manchester United who will feel they need the first goal still. They can't afford to cruise.

If they thought they could come out and just see it out, it will be tougher than that. Betis have had a chance already.

Image source, Getty Images

It hasn't been an especially fluent and attractive game. It's downright messy at times. But it's entertaining.

Gabriel Jesus starts for Arsenal, alongside Gabriel Martinelli. Captain Martin Odegaard is on the bench.

Full team news to follow.

An early chance for Betis. Their best for a while in the game.

Joaquin is fed the ball in space near the United box but he curls his shot off target.

The situation remains the same as it did an hour ago. Betis need three unanswered goals to keep this tie alive.

All Man Utd need to do is hold them at arm's length.

The second half is under way. No changes.

Rob Green
Former England goalkeeper on BBC Radio 5 Live

Erik ten Hag will be grateful of the lack of clinical edge from Real Betis. They have had enough moments in the first half.

Manchester United have had the majority of possession but it won't feel like that. They really haven't had enough control of the game.

Manchester United have failed to have a shot on target in the first of a game for the first time this season.

It's not a problem, though. They remain three goals ahead.