Striker Harry Kane becomes England's all-time top goalscorer with his 54th goal, breaking Wayne Rooney's record
Defender Luke Shaw sent off late in second half for second bookable offence
Cristiano Ronaldo becomes the most-capped men's international footballer after starting Portugal's game against Liechtenstein
England are in Group C alongside Italy, Ukraine, North Macedonia and Malta
FT: Italy 1-2 England
Paul Robinson
Former England goalkeeper on BBC Radio 5 Live
England were cruising but they just lost their way. I don't know if it was an energy thing but they just couldn't find it in the second half.
Italy improved but England just couldn't find a way through the press. The England players were out on their feet at the end.
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A lot of criticism on here. Shaw's second booking was so soft and this season has been absolutely brutal. It's no wonder legs are going when most of these lads play every 3 days at the highest level
Steve
Group C
Italy 1-2 England
North Macedonia 2-1 Malta
Group H
Kazakhstan 1-2 Slovenia
Denmark 3-1 Finland
San Marino 0-2 Northern Ireland
Group J
Bosnia-Herzegovina 3-0 Iceland
Portugal 4-0 Liechtenstein
Slovakia 0-0 Luxembourg
FT: Italy 1-2 England
Rob Green
Former England goalkeeper on BBC Radio 5 Live
What a win for England. They made hard work of it. They were in complete control but didn't perform in the second half.
They were clinging on after the red card but managed to get through it.
There were some really good individual performances in the first half but the players disappeared in the second.
FT: Italy 1-2 England
That was also Italy's first defeat in 41 European qualifiers.
It's Italy's first home defeat in Euros qualifying since 1999.
Italy 1-2 England
All over in Naples. 10-man England have held on!
They win in Italy for the first time since 1961 thanks to Harry Kane's record-breaking goal.
Italy 1-2 England
Matteo Politano, curls it in, headed away.
Last chance for Italy?
Italy 1-2 England
Jordan Pickford gathers in a deep cross after Giovanni Di Lorenzo goes to ground under pressure from Kieran Trippier. The referee isn't having any of it.
Italy 1-2 England
Harry Kane doing a job again. He gets there first and is fouled by Francesco Acerbi.
Image source, ReutersSan Marino 0-2 Northern Ireland
A solid if unspectacular three points for Northern Ireland as they beat the world's lowest ranked side.
It is however a memorable night for Bolton striker Dion Charles, who scored his first two international goals.
Michael O'Neill picks up three points in the first game of his second spell in charge of the national side.
Italy 1-2 England
Harry Kane does really well, carrying the ball down the right and into the far corner but he doesn't win the throw-in.
We've got five more minutes of this added on...
Italy 1-2 England
Two outswinging corners by Sandro Tonali are cleared. Another cross comes in and Harry Kane heads it away.
Italy come back again.
Italy 1-2 England
Giovanni Di Lorenzo is played in on the overlap but Conor Gallagher tracks him to make the block. Corner.
Italy will make a change before it. West Ham's Gianluca Scamacca is on for Marco Verratti. Gianluigi Donnarumma takes the armband.
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When will they learn...time-wasting gets you nowhere! It's not game management, it's cheating and this is what happens! Foolish!
Anon
That is so petulant and stupid from Shaw. England have been so poor 2nd half. Southgate must be wondering where our energy has gone from 1st half
Alan, Salford
Italy 1-2 England
Conor Gallagher immediately wins a free-kick as he beats Marco Verratti to the ball near the touchline.
Jordan Pickford strolls across to take it.
Italy 1-2 England
Here are those changes.
Jude Bellingham, hobbling, is off and so is Bukayo Saka.
Chelsea duo Reece James and Conor Gallagher are on.
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Such poor discipline from England. Embarrassing
Dave
This is typical England when we go a goal ahead against a decent team. We drop deeper and deeper and deeper. The equaliser seems inevitable. We have to step out!
Andrew in Preston
Italy 1-2 England
Jordan Pickford has to react to another shot and Marco Verratti almost tests him again from the edge of the box before the block comes in.
Wilfried Gnonto has been excellent since coming on for Italy.
Italy 1-2 England
A good 10 minutes for Italy to find an equaliser. England are in danger of completely crumbling.
Gareth Southgate is getting ready to bring on Reece James and Conor Gallagher. Jude Bellingham is hobbling now too.
Italy 1-2 England
Rob Green
Former England goalkeeper on BBC Radio 5 Live
It's a tackle from behind and one that Shaw didn't win. It has been a sloppy second half and a sloppy couple of minutes for Luke Shaw.