Both teams just doing some jabbing at the moment and not really going for a knockout swing, with neither side yet to make a real impression.

Another quick defensive line sees Harlequins pressure Sale with the ball and the knock on means it's a Quins scrum.

Ross Chisholm
Harlequins wing on BBC Radio London

They do and off the scrum it is a brilliant line from Sam James off a Danny Cipriani pass for Sale but his centre partner Sam Tuitupou knocks the ball on.

It's the first put into the scrum for the visitors.

Can they keep up their impressive record so far?

Image source, BBC Sport

There's been some big hits to start this game from the hosts.

Charlie Matthews lines up Sale captain Dan Braid and takes man and ball but knocks it on.

Ross Chisholm
Harlequins wing on BBC Radio London

Good early take from the lineout by Sale and after the driving maul lost momentum, Peter Stringer kicks long.

A good take by Mike Brown though and Harlequins kick to touch again.

Kicking tennis from either side in the opening minute after Mike Haley is stripped of the ball on his first run.

Marland Yarde finds a decent touch and Sale have the first line-out of the night.

Danny Cipriani gets us going.

Ross Chisholm
Harlequins wing on BBC Radio London

Sale Sharks, in their day-glo bright yellow kit, are led out by Dan Braid before Danny Care leads out Harlequins for the first time at the Twickenham Stoop. 

Here we go...

The warm ups are done and the teams are getting their final instructions in the changing rooms.

Lots of intriguing battles tonight, but has anyone spotted England captain Chris Robshaw wearing number six tonight for Harlequins? Luke Wallace is starting as openside flanker keeping the man who had the number seven shirt at the World Cup.

It can be hard being the son of a legend, but Sale number eight Josh Beaumont seems to take it all in his stride following in the footsteps of his dad Bill who captained both England and the Lions.

His impressive form last season saw him play for an England XV against the Barbarians in the summer and he's already scored one try this term as well as leading the lineout stats.

Image source, BBC Sport

Image source, BBC Sport

We've spoke about Slammin' Sam, there has been lots reaction to the news that he is quitting rugby union after one year to return to South Sydney Rabbitohs.

The 26-year-old cross-code international says it was missing his family that was the drive behind his move, but former England head coach Clive Woodward says English rugby union is a "laughing stock."

...some players get better with age, and Harlequins fly-half Nick Evans is still at the top of his game at the age of 35.

The former New Zealand international has started the season in impressive fashion including his glut of points last Saturday.

Image source, BBC Sport

What do you make of Sam Burgess' decision to move back to rugby league? Will Harlequins be too much for Sale? Is Danny Cipriani the most handsome man in rugby?

Whatever your thoughts, you can share them with us tonight using #bbcrugby.

Sale hand first starts of the season to summer recruits Peter Stringer and Nev Edwards, while Sam Tuitupou comes in for Jonny Leota and inside centre.

Youngster Sam James keeps his place at outside centre after his excellent try against Northampton, as the Sharks look for three wins in a row.

Replacements: Briggs, Flynn, Mujati, Ostrikov, Lund, Mitchell, Macleod, Leota.  

No last minute changes announced for either side so Harlequins make four changes to the team that won impressively at Bath.

Dave Ward, Will Collier and Charlie Matthews come into the pack while Matt Hopper replaces Harry Sloan at centre.

Image source, BBC Sport

Replacements: Gray, Lambert, Sinckler, Clifford, Chisholm, Dickson, Botica, Lindsay-Hague.  

Image source, Getty Images

So the Sam Burgess-less world of rugby union begins...

Round four of the Premiership action starts at the Twickenham Stoop as Harlequins welcome Sale Sharks.

Both these sides have won two of their opening three fixtures so far and sit on nine points, but who will have a third win of the 2015/16 season by the end of the evening?

Welcome to our coverage.