Image source, Getty

England have brought in wing Jack Nowell and prop Ben Moon for injured duo Chris Ashton and Mako Vunipola.

Back-row forward Brad Shields could make his Six Nations debut from the bench, alongside wing Joe Cokanasiga.

Replacements:16-Cowan-Dickie, 17-Genge, 18-Williams, 19-Launchbury, 20-Shields, 21-Robson, 22-Ford, 23-Cokanasiga.

Dafydd Pritchard
BBC Sport Wales at the Principality Stadium

Image source, Getty

This fixture is always likely to produce its fair share of contentious issues, and last year’s meeting between Wales and England was particularly controversial.

England triumphed 12-6 at Twickenham but it might have been a different story had Gareth Anscombe’s first-half try for Wales not been disallowed.

Replays suggested it was the incorrect decision, Wales head coach Warren Gatland described it as a “terrible mistake” and even World Rugby confirmed the try should have stood.

Anscombe is at fly-half today and as you can read in this interview, although he has moved on from that incident, the 27-year-old is still searching for his first Wales try and would desperately like to score it today.

Simon Gleave
Head of sports analysis, Gracenote

Image source, Getty Images

• Wales have selected 10 of the 15 players who started last year's 12-6 defeat at Twickenham start again in this year's match. The five "new" players are Tomas Francis, Justin Tipuric, Jonathan Davies, George North and Liam Williams. Francis, Tipuric and North all began last year's match on the bench while Davies and Williams were injured. Sixteen of last year's 23 are in this year's match day squad.

• This will be the seventh Six Nations match for the Wales front row partnership of Evans-Owens-Francis. This is now the most stable front row for Wales since Jenkins-Rees- Adam Jones (nine matches together in the competition from 2008 to 2013). The current trio first started together in the 16-21 defeat by England two years ago.

• Gareth Davies and Gareth Anscombe have been the starting half-backs for Wales in only one previous Test match - the 38-14 defeat of Italy in last year's Six Nations.

Wales have made 11 changes from the win over Italy, with Gareth Anscombe preferred to Dan Biggar at fly-half.

Among the other Wales returnees are captain Alun Wyn Jones, flanker Justin Tipuric, number eight Ross Moriarty and scrum-half Gareth Davies.

Liam Williams, Josh Adams, Jonathan Davies and Josh Navidi are the only survivors from the team that started in Rome.

Image source, Wales team

Replacements:16-Dee, 17-Smith, 18-Lewis, 19-Beard, 20-Wainwright, 21-A Davies, 22-Biggar, 23-Watkin.

Image source, Getty Images

Nations of millions, crowds of thousands, the eyes of people all over the globe.

But ultimately there are 46 men, half in red, half in white, who will decide this one.

With an honourable mention to referee Jaco Peyper as well...

Anyway, time for the cast list...

Dafydd Pritchard
BBC Sport Wales in Cardiff

Cardiff comes alive on a Six Nations match day, and the sun-kissed city centre streets have long been awash with red Wales shirts today.

There’s a healthy smattering of England jerseys too, with both sets of supporters mingling in the Welsh capital’s many pubs and bars.

Chat to fans from either camp and there’s a mixture of excitement, anticipation and apprehension. This is usually a fixture to shred the nerves and, while England are the bookies’ favourites today, there are few people confidently predicting a result either way.

"You are hated there," says England scrum-half Danny Care. "Some of the fans genuinely hate you. They want to make it miserable, make the atmosphere intimidating and hostile.

"The hype is exactly what you've heard," Care told the Rugby Union Weekly podcast. "It's an unbelievable place to play. The stories of people swearing at you are true - it happens.

"I remember old women giving us the middle finger. Everyone gives you stick.

"There was one lad who ran at the bus, jumped and head-butted the side of the bus. "That shows the passion, or the stupidity, of some people."

Eddie Jones and his team are on the scene.

I'm not sure how much he enjoyed his stroll off the bus and into the Principality Stadium.

It was to the backing of a male voice choir belting out Bread of Heaven.

Eddie Jones had a glint in his eye and an arch in his brow as he spoke to the media this week.

"We are going to enjoy the environment. How fantastic is it, the English going to Wales, 65,000 people there, all expecting Wales to win and us going there to play a brutal physical game, play smart rugby and come off victors?" said the England coach.

"They have been talking about how they have to stop players ripping other players' heads off, external, how it is their biggest game ever, for us it is our most important game.

"We don't have to worry about getting extra motivated, all we have to be is right for the game."

Becky Grey
BBC Sport in Cardiff

This was the queue outside the Principality five and a half hours before kick-off. Needless to say there is more than a hint of expectation in the Cardiff air.

There’s no way you could fail to notice there’s a rugby match happening here today. I even saw a bus driver in a Wales jersey earlier.

Image source, BBC Sport

Image source, Getty Images

I'm not sure what John Terry had to say in midweek at Pennyhill Park, but his speech to the England team probably was not quite so tasty.

The Wales team meanwhile went to watch 'Grav' - a play based on the life of former international and proud patriot Ray Gravell - staged in the away dressing room at the Principality Stadium on Monday night.

"We should have played them straight after that," said forwards coach Robin McBryde.

This one just means more.

Image source, Getty Images

Phil Bennett, in a changing room a few hundred metres from the Millennium Stadium, March 1977: "Look what these b******* have done to Wales. They've taken our coal, our water, our steel. They buy our homes and live in them for a fortnight every year. What have they given us? Absolutely nothing. We've been exploited, raped, controlled and punished by the English — and that's who you are playing this afternoon."