Six Nations 2015: Sergio Parisse ruled out of Wales game

Sergio Parisse came off in the 74th minute against France

Italy captain Sergio Parisse has lost his fitness battle and will miss Saturday's Six Nations match with Wales in Rome.

Stade Francais star Parisse suffered foot ligament damage in his side's 29-0 defeat by France on Sunday.

Tight-head prop Martin Castrogiovanni returns and Mauro Bergamasco comes into the back row in a team showing four changes from the one beaten by France.

Fly-half Kelly Haimona returns and Michele Rizzo comes in at loose-head.

Lorenzo Cittadini drops to the bench to make way for Castrogiovanni, and Leicester flanker Robert Barbieri returns among the replacements as Marco Barbini drops out.

Wales need a big win over Italy to put pressure on Ireland, who play Scotland, and England who face France in the race for the title.

All three teams have won three matches, but Ireland and England have far superior points differences.

Italian team to play Wales

Luke McClean (Sale Sharks); Leonardo Sarto (Zebre Rugby), Luca Morisi (Benetton Treviso), Andrea Masi (London Wasps), Giovambattista Venditti (Zebre Rugby); Kelly Haimona (Zebre Rugby), Edoardo Gori (Benetton Treviso); 1 Michele Rizzo (Leicester Tigers), Leonardo Ghiraldini (Leicester Tigers, capt), Martin Castrogiovanni (RT Toulon), George Biagi (Zebre Rugby), Joshua Furno (Newcastle Falcons), Francesco Minto (Benetton Treviso), Mauro Bergamasco (Zebre Rugby), Samuela VUNISA (Zebre Rugby)

Replacements: Andrea Manici (Zebre Rugby), Alberto De Marchi (Sale Sharks), Dario Chistolini (Zebre Rugby), Quintin Geldenhuys (Zebre Rugby), Robert Barbieri (Leicester Tigers), Guglielmo Palazzini (Zebre Rugby), Luciano Orquera (Zebre Rugby), Enrico Bacchin (Benetton Treviso).