Manu Tuilagi and Ben Youngs withdraw from England training camp through injury
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Tuilagi's last England appearance came against Wales during the 2016 Six Nations
Leicester centre Manu Tuilagi and scrum-half Ben Youngs have withdrawn from England's training camp in Bristol with injuries.
Worcester prop Nick Schonert is out injured and Harlequins prop Joe Marler has withdrawn for personal reasons.
Tuilagi was recalled to Eddie Jones' 36-man squad on Thursday, having not played for England since early 2016.
Leicester said both players had sustained "niggles" in Sunday's 44-37 Premiership defeat by Worcester.
"They will be assessed by the club in the next few days," said a club spokesperson.
Exeter prop Ben Moon and Leicester wing Jordan Olowofela have both been called up as replacements.
Jones will name his squad for the November internationals on 18 October, before a training camp in Portugal.
England face South Africa, New Zealand, Japan and Australia in consecutive weekends at Twickenham.