Wales made promising start but Canada secured four-try bonus and led 28-0 at half-time thanks to McKinley Hunt's double and scores by Alysha Corrigan and Asia Hogan-Rochester.
Welsh number eight Georgia Evans yellow-carded for a high tackle in 48th minute, followed by Taylor Perry and Brittany Kassil going over for Canada.
After heavy loss to Scotland in opening match, Wales were nilled and are set for a group-stage exit.
Canada, ranked second in the world, have shown their credentials as challengers for the trophy by cruising past Fiji and Wales.
Live Reporting
Postpublished at 11:54 BST 30 August
11:54 BST 30 August
Canada v Wales (12:00 BST)
Ceri Coleman-Phillips BBC Sport Wales rugby reporter at Salford Community Stadium
The stands are filling up nicely now as the giant flags are rolled out across the pitch and the pyrotechnics go off.
The fans are getting ready to welcome the teams as Gwenllian Pyrs leads Wales out ahead of her 50th cap.
Wales have to be 'brave'published at 11:52 BST 30 August
11:52 BST 30 August
Canada v Wales (12:00 BST)
Philippa Tuttiett Former Wales international
There's been a overhaul of changes for the Wales squad.
Sean Lynn has brought in seven new players, mostly in the pack, which tells me he's looking for a more physical presence in this team.
They've got to be brave today, they've got to forget they are playing the number two team in the world, they've got to forget about the superstars they are up against.
It's a game of rugby, so take the opportunity and beat your player.
Let us look at some facts and figures of the two sides:
Canada have won each of their last seven games against Wales, with each of those victories coming by 15+ points. Wales' last win against the Canucks came in May 2006 (16-11)
Wales and Canada have met four times previously at the Rugby World Cup, they drew their first meeting in 1991 (9-9) with Wales winning three years later (11-5). However, the Canucks have won their two meetings since then, both in 2017 without conceding a single point (15-0 in the Pool stage, 52-0 in the play-offs)
Canada retained possession from 89 of their 90 attacking rucks against Fiji, with their 98.9% ruck success rate being the best of any nation in the opening round of fixtures at Rugby World Cup 2025
Wales won eight turnovers against Scotland, with each of those turnovers coming at the breakdown – no other side won more than five turnovers at the ruck in the opening round of Rugby World Cup 2025.
Canada full-back Julia Schell scored six tries against Fiji, the most by any player in a Rugby World Cup match since New Zealand's Portia Woodman-Wickliffe scored eight against Hong Kong China in 2017.
Canada aim to show the strength of their squad after head coach Kevin Rouet opted to tinker with the XV that dismantled Fiji 65-7 in York.
The boss makes five changes to the starting line-up with loose-head prop McKinley Hunt and hooker Emily Tuttosi getting the nod in the front row.
Karen Paquin, who is playing in her fourth World Cup, starts at openside flanker while wing Asia Hogan-Rochester is at the other end of the spectrum and makes her tournament debut.
Lock Tyson Beukeboom is already Canada’s most-capped women’s player and will go level with men’s player Aaron Carpenter on 80.
Julia Schell keeps her spot at full-back after crossing for six of the 11 tries against Fiji.
Canada: Julia Schell; Alysha Corrigan, Florence Symonds, Alexandra Tessier (capt), Asia Hogan-Rochester; Taylor Perry, Justine Pelletier; McKinley Hunt, Emily Tuttosi, DaLeaka Menin, Sophie de Goede, Tyson Beukeboom, Caroline Crossley, Karen Paquin, Gabrielle Senft
Welcome to Salfordpublished at 11:26 BST 30 August
11:26 BST 30 August
Canada v Wales (12:00 BST)
Image source, Getty Images
Good morning and welcome to our live coverage of a huge
game for Wales as they attempt to stun Canada in Pool B of the World Cup.
Sean Lynn’s side are back in Salford and they are up
against it after being hammered 38-8 by Scotland at this venue last Saturday.
That means that they need to cause a huge upset against
Canada, who are ranked second in the world.
Fail and Wales will be out of the tournament if Scotland safely
negotiate their game against Fiji in the second part of Saturday's double-header in
the north west of England.
The bookies don’t fancy the Welsh chances but can we
witness something special? Settle in and follow events with us right here.