Ireland take on South Africa in first of two Tests in Pretora (16:00 BST)
Andy Farrell's side have only won once on South African soil - in June 2016 - and have never won a series.
This will be Farrell's last series before taking a year sabbatical to lead the British and Irish Lions in Australia in 2025.
Farrell hands a debut to Leinster full-back Jamie Osbourne with Munster's Craig Casey preferred to Conor Murray at scrum-half.
South Africa name 12 starters from the World Cup final win over New Zealand with scrum-half Faf de Klerk passed fit after an injury doubt.
The double world champions are the number one ranked side in world rugby with Ireland currently ranked second.
South Africa 13-8 Ireland
Casey was tackled by RG Snyman and the back of his head hit the grass hard as he landed.
It all appears to be legal, but let's hope Craig is okay after that one. That's the main priority.
Conor Murray is already on the pitch in place of his Munster team-mate.
South Africa 13-8 Ireland
Alan Quinlan
Former Munster and Ireland flanker on Sky Sports
Very little chase on kicks and the line speed has slowed but Ireland are hanging in there. What a climax in store.
Image source, Getty ImagesSouth Africa 13-8 Ireland
Craig Casey looks to be in a bit of trouble here. We've yet to see a replay but he's getting treated by the medics.
South Africa 13-8 Ireland
Andrew Porter is back on the pitch after getting the blood attended to, and Finlay Bealham is on too.
Just before that, Casey sent a delightful kick into the 22 and Ireland have the throw!
South Africa 13-8 Ireland
This has become a bit like Wimbledon and the ball is being sent end-to-end with the kicks.
Who will blink first?
South Africa 13-8 Ireland
Alan Quinlan
Former Munster and Ireland flanker on Sky Sports
Caelan Doris was arguing with Luke Pearce that Kelleher hooked it back before he hit the deck and it is so close. Ireland have been under so much pressure and it is such small margins at the breakdown that may make the difference in this test match.
Handre Pollard
It's well wide by Pollard. Not even close.
Ireland are still in it with 20 minutes to play!
South Africa 13-8 Ireland
It was brilliant by Lowe, but it counts for nothing!
Kelleher was deemed to be on the ground when he won the ball, so it's disallowed and South Africa have the penalty!
South Africa 13-13 Ireland
It seems to be a question over whether Kelleher was on the floor when he hooked the ball back.
South Africa 13-13 Ireland
Oh, hang on. There's a quick TMO check for a possible knock on.
James Lowe
SENSATIONAL!
Ireland win the turnover inside their own half and Casey spots Lowe on the left wing.
The Leinster wing beats Marx, and then holds off Handre Pollard and sprints clear to score.
Image source, InphoSouth Africa 13-8 Ireland
Jonathan Bradley
BBC Sport NI
The first thing we saw from the 'Bomb Squad' was a penalty surrendered at the scrum but there's an impact from Malcolm Marx. So good at the breakdown, that was textbook from the hooker.
Ireland getting on the wrong side of Luke Pearce at the worst possible time here, four penalties of the last five have gone against them.
South Africa 13-8 Ireland
A kick wide almost sets Kolbe free o the right wing but James Lowe just does another to break his stride.
The Boks still have the ball, and now it's the turn of the forwards to make their move.
South Africa 13-8 Ireland
It's HUGE defence from South Africa.
Ireland are piling the bodies forward and Malcolm Marx is there to get his body over the ball. Big turnover.
South Africa 13-8 Ireland
Alan Quinlan
Former Munster and Ireland flanker on Sky Sports
A great kick from Casey but that was a superb turnover by Josh van der Flier. Ireland are under pressure but they are hanging in there and that could be crucial.
South Africa 13-8 Ireland
RG Snyman, a familiar face to Munster and Leinster fans, spills the line-out and Ireland have a scrum right on the 22.
This is a good platform if they get this right.
South Africa 13-8 Ireland
There's a lot of blood on Andrew Porter's hard as he jogs off, and Cian Healy is on in his place.
Not a bad man to bring on as Healy moves within three caps of Brian O'Driscoll's Irish record.
Image source, InphoSouth Africa 13-8 Ireland
That's a superb clearing kick by Craig Casey, who has been quietly efficient on the biggest start of his career.
Josh van der Flier produced a stunning turnover in the lead-up to that.
South Africa 13-8 Ireland
Quick as a flash, the hosts are well inside the Irish half, with Kriel making most of the yards before he's met by a meaty tackle by Ciaran Frawley, who is also on in the Irish back line.
South Africa 13-8 Ireland
Alan Quinlan
Former Munster and Ireland flanker on Sky Sports
Rassie Erasmus perhaps smells blood and bringing on a raft of quality replacements might help kick his side up a notch.
Image source, Getty Images
