A crowd of 21,186 watched Wales v England at the Principality Stadium - a record for a Wales women's home game in any sport.
Wales take an early lead though Jenni Scoble's try, but are quickly on the backfoot.
Maddie Feaunati (2), Megan Jones and Sarah Bern all score for England, who secure a bonus-point before the half-hour mark.
Ellie Kildunne scores a second-half hat-trick on her 50th cap for England to move visitors 43-7 ahead.
Wales score their second try of the match on the hour mark, Kate Williams crossing.
Abby Dow and Abi Burton scores two tries each in the closing stages, as England finish 67-12 winners.
Live Reporting
Matt Lloyd
Goodbye from Cardiffpublished at 19:04 Greenwich Mean Time 29 March
19:04 GMT 29 March
FT: Wales 12-67 England
Image source, Getty Images
Well just for a moment, for 10 minutes, we wondered if Wales could mark the 10-year anniversary of their last win over England with a repeat after Jenni Scoble's early try.
But that simply stirred the beast as England smashed their hosts with 11 tries to stay in control of the Six Nations.
Ellie Kildunne celebrated her 50th cap with a hat-trick of tries and a player of the match display as the world's number one team showed their class.
Maddie Feaunati and Abby Dow both scored twice - as did Abi Burton in a remarkable nine-minute emotional Test debut.
Cardiff-born Meg Jones and Sarah Bern added scores as England ran riot.
Kate Williams crossed in the second half for Wales as the Sean Lynn era waits for its first win.
But at least it gave a Welsh record crowd of 21,186 something to cheer.
The Six Nations takes a break next week but you can follow all the latest news on the BBC Sport website.
'We can't afford to get bored with the basics' - Mitchellpublished at 18:57 Greenwich Mean Time 29 March
18:57 GMT 29 March
FT: Wales 12-67 England
Image source, Getty Images
England head coach John Mitchell told BBC Sport: "We didn't start particularly well, but we grew into the second half, and built some good pressure.
"I'm really glad the way we responded to what Wales did to us.
"I think we're a side that can't afford to get bored with the basics, because when our basics are poor that lets us down and brings the opposition into the game.
"I think we had 450 more kicking metres, we went after the middle of the pitch and eventually the back-field came.
"I think we've got the best team in the world in terms of where our kicking is progressing. Andrew Holloway that works with girls is really advancing in that area."
Postpublished at 18:54 Greenwich Mean Time 29 March
18:54 GMT 29 March
FT: Wales 12-67 England
I'm not sure if this is a fair comparison, but it is only two weeks since England's men inflicted almost an exact same score (14-68) here at the Principality Stadium.
A lot of emotions for England's Cardiff-born Jonespublished at 18:52 Greenwich Mean Time 29 March
18:52 GMT 29 March
FT: Wales 12-67 England
England's Cardiff-born centre and try-scorer Meg Jones told BBC Sport: "I haven't played here [at the Principality Stadium] since I was 12 years old so it was great to get a runout.
"There have been a lot of emotions this week that I've tried to hold in but then I heard both anthems and it was emotional.
"I just tried to enjoy it as much as possible.
"We played some good rugby but we're always hyper-critical and there were a few errors out there. But we stayed on top.
"The competition is really pushing us on. Emily Scarratt is my competition so you can imagine how that pushes you.
"But we have to keep our feet on the ground as we look to progress. It's about the here and now."
'Every game we've got to get better' - Lynnpublished at 18:49 Greenwich Mean Time 29 March
18:49 GMT 29 March
FT: Wales 12-67 England
Image source, Huw Evans Picture Agency
Wales head coach Sean Lynn told BBC Sport: "A massive thank you to everyone that's come here today, what an amazing occasion.
"Everything I've talked about is making sure we're always moving forward, I thought some of our attack today was outstanding but we just fell away.
"We have to remember we're playing against the best team in the world.
"We have to get better, every game we've got to be getting better. We've got France, Ireland and Italy left, and we've got to keep getting better and better. Simple.
"I was asking them 'how hard are they willing to fight for each other' and they certainly showed they could today."
'We are back on track' - Aldcroftpublished at 18:46 Greenwich Mean Time 29 March
18:46 GMT 29 March
FT: Wales 12-67 England
England captain Zoe Aldcroft told BBC Sport: "We needed that performance after Italy. All week we spoke about intent and giving an 80-minute performance.
"We slipped on execution a little in the first half so we spoke at half-time about getting back on track by being direct with strong ball-carriers.
"I can't fault the effort and intent from the girls."
'We're going to keep on getting better' - Kildunnepublished at 18:43 Greenwich Mean Time 29 March
18:43 GMT 29 March
FT: Wales 12-67 England
Image source, Getty Images
Player of the match Ellie Kildunne told BBC Sport: "Honestly it doesn't get better than that
"You can't write it, I couldn't have imagined it, everything today has just fit in.
"We've still got a lot to work on, but to walk out on my 50th cap in front of such a great crowd in an amazing stadium is something I'm very honoured for.
"Pressure is definitely a privilege, every time we step out as an England squad we want to surprise, and raise the expectation because we want to keep on going. We're not at our best yet, we're going to keep on getting better and there's a lot more to come.
"[We could achieve] the unimaginable. We're going to keep on getting better, I really think we're going to go to levels we've never been to before!"
Postpublished at 18:37 Greenwich Mean Time 29 March
18:37 GMT 29 March
FT: Wales 12-67 England
Rachael Burford England World Cup winner on BBC Radio Wales
Everybody loves the Six Nations but everybody playing is thinking about the World Cup.
This tournament here is your selection, can you step-up and deliver for your country. Most of the World Cup teams will be selected after the Six Nations finishes.