Political analysis: Loss of East's MEP will hit Labourpublished at 11:08 British Summer Time 5 September 2016
Andrew Sinclair
BBC Look East political correspondent
This news East of England MEP Richard Howitt is standing down will come as a big blow to Labour supporters in the East.
For many years Richard Howitt has been the face of Labour in the region, the linchpin who held the party together after the the disastrous election defeat of 2010, the politician who could always be relied on to turn up at a local branch fundraiser.
But what will also come as a blow will be the fact that he has chosen to leave politics now.
As an MEP, he knows he will lose his job when we leave the EU in a few years time, but for now there is still a job to be done in Brussels arguing for the UK's interests as Brexit negotiations get under way and the party would more than likely have rewarded his hard work with another job back in Britain.
Friends tell me that Jeremy Corbyn's leadership of Labour has been a factor in today's decision: he worries for the future of the party he loves and he fears Labour will be unelectable for some time to come.
But he also feels that as a British MEP he is starting to lose his influence, he's in his mid-50s and wants another career challenge before retiring.
There are many reasons for his decision, but there's no denying that for Labour in the East this is a big loss.