Speaking to the BBC, the Scottish First Minister Nicola Sturgeon says the prime minister and the government "should be out of office".

"This is a dereliction of duty," she says.

"It is the prime minister’s failure to listen after the first defeat and pandering to Brexit extremists that has made tonight's outcome inevitable.

"The UK is teetering on the edge and the government has stopped functioning."

Former Attorney General Dominic Grieve says Theresa May's Brexit deal is now "finished".

The Tory MP, who voted against the prime minister's plan, said he was confident the majority of MPs would now be voting against a no-deal Brexit.

He told the BBC he hoped the Commons would then vote for an extension to the Article 50 process.

"We are going to have to make use of this extension period sensibly to get us out of this terrible mess, because we are in the midst of a major political crisis," he said.

But Mr Grieve, who opposes Brexit, added: "We also need to get away from this idea that, just by delaying and running down the clock, the House could be persuaded to vote the current deal through. I think the current deal is finished.

"My anxiety is that even if the prime minister could get it through by arm twisting, the consequences subsequently would unravel because it's not just about getting the deal through.

"You have then got to enact primary legislation to implement it at a national level."

Image source, AFP/Getty Images

Europe Minister of France, Nathalie Loiseau, says: “This evening’s vote in the Commons is bad news.

"The EU has given all possible assurances, in addition to the withdrawal agreement.

"We have reached the end of the negotiations on withdrawal because we must protect the interests of Europeans.

"We are 17 days from the UK's departure from the EU. The solution to the current impasse can only be found in London.

"For our part we are ready for all scenarios, including that of a Brexit without agreement.”

BBC Radio 5 Live

5 Live’s Lesley Ashmall has been gauging the public mood in Dover.

Ferry worker Dominic is worried that a no deal Brexit would affect the efficiency of the ferry crossings.

“There’s got to be a deal. If there’s no deal – nobody knows where we stand. And that’s what everyone’s saying on board – we need to know how we’re going to run.

“I think personally they need to delay it and sort it out properly before there is massive destruction."

Image source, 5 Live

Kath and Bevan from Yorkshire are off to Austria on their travels, and are angry about the political situation.

“I think we should stick up two fingers up to the EU,” said Bevan.

“We’re Great Britain. We’ve got plenty of rabbits in the field. We can plant potatoes in the back garden. We’ve managed before.”

Kath initially voted to stay in but has since changed her mind.

“I voted to stay in but having heard the attitude of the EU discussions, I think they’ve treated our PM disgustingly and I think we ought to stay out of it. If it means no deal, it means no deal.”

Image source, 5 Live

Lastly, Lesley spoke to retiree Mark, who was initially “keen” to leave the EU but has since changed his mind.

He would now like a second referendum.

“I’m beginning to waver now and I think staying in may be the best option,” he said.

Image source, 5 Live

For more Brexit reaction, and to have your say on the day's events, listen to BBC Radio 5 Live on BBC Sounds.

Image source, Reuters

Reacting to tonight's vote, Sinn Féin President Mary Lou McDonald said: "The British Parliament voted by a landslide to reject the withdrawal agreement and Theresa May's latest proposals.

"The scenes tonight show the absolute disregard for the people of Ireland, for our rights, our economy and the Good Friday Agreement that is at the heart of the Tory Brexit agenda.

"Sinn Féin, and the majority of parties across this island, know there is no good or sensible Brexit.

"There is now a need to intensify planning for a no-deal crash with an imperative to ensure no return to a hard border, protections of our agreements and safeguarding the rights of citizens.”

Image source, Getty Images

The pharmaceutical industry has reacted to the vote by reiterating its warning that stocks of some medicines could be affected in the event of a no-deal.

Mike Thompson, chief executive of the Association of the British Pharmaceutical Industry, said: "With just days remaining we need a solution which avoids a no-deal Brexit and the potential harm it could cause."

He said companies have done everything in their power to prepare for a no-deal, including increasing stocks and adding new supply routes.

"Despite these efforts, we have always said that in a no-deal scenario, we could face the very real possibility of disruption to the supply of some medicines."

Image source, Reuters

Ireland's Foreign Affairs Minister Simon Coveney told the BBC: "The predictions were consistent enough over the last few days that this would be a heavy defeat.

"We now need to be patient and calm to allow this process in Westminster to take its course."

BBC News Channel

The Independent Group MP Sarah Wollaston, who voted against the deal, said the prime minister was now presenting MPs with a motion offering a "false binary choice between having a deal and having no deal".

Ms Wollaston - who was one of three MPs to leave the Tories last month to join the new grouping in Parliament - said: "There are other options.

"We would like to see [the no-deal motion] amended tomorrow to make it absolutely clear that under no circumstances will the House of Commons accept the government taking us out without no deal at all."

She added: "My preference would be to put a deal to the British people - give them a right to vote.

"But the other option as a very last resort if we were about to crash out would be revoke it altogether."

UK Parliament photographers Jessica Taylor and Mark Duffy captured the following shots in the Commons today.

Image source, UK Parliament

Image source, UK Parliament

Image source, UK Parliament

Image source, UK Parliament

Image source, EPA

The Prime Minister of Denmark Lars Lokke Rasmussen has tweeted “meget trist” - translating as "very sad" - after tonight's vote.

Foreign Minister of Denmark Anders Samuelsen says: “The ball is again in the British court. It must be up to the British government and the British Parliament to come up with solutions.

"Meanwhile, the government is continuing our preparations for a no-deal scenario, so we are prepared no matter which direction it is going.”

Austrian Europe Minister Gernot Blumel says: “Unpleasant result of today's vote in the British Parliament.

"The EU and the Austrian Federal government, of course, are also prepared for an approaching no-deal.

"However, we are still convinced that an orderly exit would be the better solution for all sides. It's up to the UK.”