Forty-nine people killed in attack on gay nightclub - the worst mass shooting in recent US history
Suspect took hostages and died in gunfight with Swat officers
He is named as 29-year-old Omar Mateen, US national
Mateen investigated twice by FBI since 2013, but was not on active terrorism watch list
US President Obama says no evidence he was part of a larger plot
Officials investigating the shooting say they are "confident" there are no additional threats to the US.
"We feel confident there are no immediate threats to the area or the United States of America," says FBI special agent Ronald Hopper.
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Describing the situation inside the Pulse nightclub, Orlando Mayor Buddy Dyer says "there's blood everywhere".
Orlando police chief John Mina describes the attack as a "tragedy not just for our city, but for the entire nation".
He says officials will soon start identifying the victims and notifying next of kin.
The new confirmed death toll - 50 casualties - makes it the worst mass shooting in recent US history.
There will be another briefing in three hours.
Image source, Getty ImagesOrlando surgeon Michael Cheatham says many of the wounded are critically ill as a result of their injuries.
Six trauma surgeons have been brought in, he adds.
Orlando Mayor Buddy Dyer says 50 people have been killed and 53 injured.
US officials have now confirmed that the suspected attacker was Omar Mateen, a US citizen from Florida.
The fire service of Orange County, where Orlando is located, has issued this appeal:
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CBS News has more information on the suspect. Police have yet to officially identify the suspect.
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Image source, APNext media update is now expected at 10:15 local time (15:15 BST)
An FBI bomb squad is on the scene with a robot searching for possible booby traps, a source tells the BBC.
The man being investigated for the gun attack at the Orlando nightclub is 29-year-old Omar Mateen, the BBC understands.
It is believed the US citizen was not on a terrorism watch list, though he was currently being investigated for a previous unrelated criminal act.
Local journalist Paul Brinkmann says counsellors are being called in to help all those affected by the attack in the Pulse nightclub, which describes itself as Orlando's premier gay nightspot.
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The White House has just released a statement about the shooting in Orlando.
It says President Barack Obama "was briefed this morning by Lisa Monaco, assistant to the President for Homeland Security and Counterterrorism".
"Our thoughts and prayers are with the families and loved ones of the victims.
"The president asked to receive regular updates as the FBI, and other federal officials, work with the Orlando Police to gather more information, and directed that the federal government provide any assistance necessary to pursue the investigation and support the community."
Image source, APA police officer stands guard outside the ORMC hospital
Orlando Regional Medical Center (ORMC) has been treating many of the wounded and has set up a meeting area for those concerned about relatives.
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Image source, ReutersDuring his news conference (see 12:27 entry), Orlando police chief John Mina also said that at least 30 people were saved during the rescue operation at the club. About 320 people were in the club when the shooting started.
The next media briefing is planned for 09:30 local time (13:30 GMT), police say.
Eyewitness Anthony Torres has been writing about his experience on his Facebook page, external.
He and his friends decided to leave Pulse nightclub just before the shooting started.
Mr Torres has also posted some videos from outside the venue.
Quote MessageShots fired Pulse Orlando... made it out just barely as we started to hear fire being shot !! People are screaming that people are dead !! Crazy...
Quote MessageThey are just pulling people out in stretchers loading them up.. Omg please god let everyone make it - tonight was supposed to be a fun night!! One more minute and we would of been shot or worse..
Quote MessageWe were sitting in the VIP section right by the entrance.. We decided to get up and leave ... Not even a few seconds later is when it all started.. People where screaming and running looking for their loved ones along with seeing injured people sitting on the floor .. It was so surreal .. it seemed fake... This had to be planned...
Quote MessageWe were lucky to walk away from this, but my condolences to the friends and family who lost their loved ones tonight and for everyone that has been injured tonight; i'm praying for you all..
Witnesses have heeded a call from the Orlando Police and are gathering at its headquarters to provide information. Some are being dropped off by bus.
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Image source, APThe Pulse nightclub, where the shooting took place, is located in the centre of Orlando.
