Chiefs' supremo Andy Reid is never one to dodge a gamble.

Fourth-and-two at midfield and he rolls the dice - Patrick Mahomes finds Xavier Worthy with a quick roll-out and pass to convert.

Two of the NFL's most experienced head coaches going head-to-head tonight - John Harbaugh and the Chiefs' Andy Reid.

All smiles together before kick-off - will it last?

Image source, Reuters

Greg Brady
NFL pundit on BBC Radio 5 Sports Extra

Baltimore can pile up the points and they have soft portion of their schedule coming up.

They are going to roll on some teams after this game whether they win or lose it.

Fast start from the Baltimore Ravens who are already close to the Chiefs' redzone after Lamar Jackson finds Zay Flowers with a bullet of a pass.

Flowers takes a big hit from a tackler but bounces straight back up.

There'll be some tough tackling all night between these two big rival franchises.

These are the key storylines from the seven 18:00 BST games:

Eagles win battle of unbeaten teams

The Philadelphia Eagles and Tampa Bay Buccaneers came into this game unbeaten and the Eagles came out on top in a thriller.

They dominated early on, leading 24-6 at one point, but the Bucs fought back, the Eagles held on and it finished 31-25.

Dart leads Giants to debut win but Nabers injured

Quarterback Jaxson Dart impressed on his first start as the New York Giants pulled off one of the shocks of the season so far, beating Justin Herbert's Los Angeles Chargers 21-18.

However, there wasn bad news for New York as star receiver Malik Nabers suffered a reported ACL injury.

Lions offence > Browns defence

The Detroit Lions' explosive offence ws on top against the Cleveland Browns' number one-ranked defence with Jahmyr Gibbs and Amon-Ra St. Brown impressing in a 34-10 win.

Bills hold off Saints to go 4-0

And the Buffalo Bills were expecting to easily beat the New Orleans Saints but were made to work hard to win 31-19 and remain unbeaten.

BBC Radio 5 Sports Extra

Use the button at the top of the page to listen to Ravens v Chiefs, Lamar v Mahomes - it should be a cracker.

• Tennessee Titans 0-26 Houston Texans
• Carolina Panthers 13-42 New England Patriots
• Los Angeles Chargers 18-21 New York Giants
• Philadelphia Eagles 31-25 Tampa Bay Buccaneers
• Cleveland Browns 10-34 Detroit Lions
• New Orleans Saints 19-31 Buffalo Bills
• Washington Commanders 27-34 Atlanta Falcons

Image source, Getty Images

With six seconds left, Philadelphia decide against punting and instead decide to take a safety, conceding two - redundant - points to allow the clock to run out.

The game ended up closer than looked likely at half-time when the dominant Eagles were 24-6 up, helped by some Bucs mistakes.

Baker Mayfield led a decent second-half rally but Tampa left themselves just too much to do as they slip to 3-1 while the Eagles stay unbeaten at 4-0.

A huge upset in New York as Jaxson Dart impressed on his debut as Giants quarterback to lead his side to shock victory over Justin Herbert's Chargers.

That's the Giants' first win of the season but their joy will be tempered some what by that injury to Malik Nabers.

Image source, Getty Images

OK, the season is only three games in.

But after tonight, barring an unlikely tied result, one of these AFC playoff mainstays will have a 1-3 record.

In fairness, both have endured tough starts schedule wise - the Chiefs beaten by 3-0 pair Philadelphia and LA Chargers while Baltimore pushed fancied duo Detroit and Buffalo all the way in narrow defeats.

But Patrick Mahomes and Lamar Jackson will understand the importance of tonight's marquee meeting - neither will want to fall too far behind the 8-ball as the saying goes.

The New Orleans Saints gave Buffalo more to handle than many might have expected.

But Josh Allen stepped up when needed to help the Bills continue their perfect start.

Fourth down and 10 proves too much as the Eagles get Baker Mayfield under pressure and while he finds a receiver, he's well short of the line to gain.

Philadelphia will take over on downs and that should be that.

That was no contest in the end as the high-powered Lions offence dominated the Browns, who had the number one-ranked defence before today.

The Lions have too many offensive weapons and Browns QB Joe Flacco could not get anything going.

How long before a quarterback chance in Cleveland?

Rachaad White gets a chunk of that yardage back but it's still fourth down and a must-convert for the Bucs...

Baker Mayfield takes a thunderous sack and it's a massive yardage loss on second down for the Buccaneers.

Third-down-and-23 with 1:45 on the clock.

Inside the two-minute warning at Raymond James Stadium where an absolute bulldozing run from QB Baker Mayfield just gained the Buccaneers a vital first down.

Image source, Reuters

A late Washington field goal is not enough to prevent an Atlanta victory in a fun affair at Mercedes-Benz Stadium.

Two of tonight's late games are underway - the big one is Ravens at Chiefs in 20 minutes. Tune in to BBC Radio 5 Sports Xtra or use the button at the top of the page to listen to that one.

21:05 BST

• Indianapolis Colts (3-0) @ Los Angeles Rams (2-1)
• Jacksonville Jaguars (2-1) @ San Francisco 49ers (3-0)

21:25 BST

• Baltimore Ravens (1-2) @ Kansas City Chiefs (1-2)
• Chicago Bears (1-2) @ Las Vegas Raiders (1-2)