Speaking of injuries to some of the Indianapolis Colts' key players...
Cornerback Sauce Gardner, who joined from the New York Jets midway through the season, has headed straight into the locker room after picking up what looks to be a foot injury.
He could hardly bear anywhere weight on his left foot and is now questionable to return.
De'Von Achane scores on a 29-yard rush as Miami strike first. Tua Tagovailoa was sacked early on the drive, but responded with two nice completions before a well drawn-up run play saw their lively running back burst clear.
Rams look to extend winning streakpublished at 17:58 GMT
17:58 GMT
Los Angeles Rams @ Carolina Panthers (18:00 GMT)
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The Los Angeles Rams are hoping to tighten their grip on the NFC's top seed when they travel to Carolina to take on the Panthers.
An impressive victory against the Tampa Bay Buccaneers last time out saw Sean McVay's Rams move to 9-2 and take control of the NFC for the first time this season.
The Rams are on a six game winning streak going into this one and haven't trailed in a match since being 3-0 down to the Baltimore Ravens in week six.
It's a big game in its own right for the Panthers, too, as a win could see them move into pole position in the NFC South.
Sanders gets another chance to shinepublished at 17:57 GMT
17:57 GMT
San Francisco 49ers @ Cleveland Browns (18:00 GMT)
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Rookie Cleveland Browns quarterback Shedeur Sanders will get another chance to impress from the start when he leads his team out at Huntington Bank Field for the first time.
Sanders was able to get a win in his first NFL start last week against the Las Vegas Raiders, and showed glimpses of the talent that many expected to see get him drafted in the first round of this year's draft.
The test in front of him today is a much sterner one than that of Las Vegas but the rookie certainly doesn't lack confidence and will be determined to make a statement in what is his first start inside the Dawg Pound.
Baker Mayfield suffered a shoulder injury in last week's loss to the Los Angeles Rams.
Good news on the injury front for both of these teams. Baker Mayfield and Bucky Irving are both active for the Bucs.
They remain in control of the NFC South (6-5), but the Carolina Panthers are breathing down their neck (6-6)
Marvin Harrison Jr. will be on the field for the Arizona Cardinals. They are as good as out of the playoff picture though, with quarterback Kyler Murray out for the season.
Colts looking to overcome Texans after Chiefs defeatpublished at 17:54 GMT
17:54 GMT
Houston Texans @ Indianapolis Colts (18:00 GMT)
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In the more close-fought of the two AFC South derbies, the Colts host the Texans in Indianapolis.
Both sides host positive records this season, with the Colts 8-3 and the Texans 6-5 for the campaign.
The Texans are in better recent form following three straight wins, including one last time out against the Buffalo Bills. The Colts lost narrowly to the Kansas City Chiefs a week ago.
The lowly Saints are just 2-9 and will start thinking about 2026 soon, but for Miami, they're looking to win a third game in a row, and at 4-7 they still technically have admittedly slim play-off hopes.
One of their back-to-back wins came against Buffalo, so there's obviously some quality there, and Mike McDaniel needs a good end to the season to convince the team he's the man for the future.
Things haven't exactly gone to plan for either of these franchises in 2025.
The Falcons are 4-7 and back to Kirk Cousins under centre after Michael Penix Jr. suffered a knee injury, which ended his season. Their divisional win over the New Orleans Saints last week ended a five-match losing streak.
Justin Fields was benched for Tyrod Taylor in their last outing - falling to the Baltimore Ravens - in what has been another sub-par season for the Jets. A few pundits are predicting a Jets win today, though, make of that what you will.