Were you at the game or following from elsewhere?
Saints fans - what did you make of the match?
Brentford supporters - let us know your thoughts
Come back to this page on Monday to find a selection of your replies
There are seven games in the Premier League on Saturday, and we will bring you every moment.
Tottenham v Newcastle (12:30)
Aston Villa v Leicester
Bournemouth v Everton
Crystal Palace v Chelsea - listen on BBC Radio 5 Live
Man City v West Ham
Southampton v Brentford
Brighton v Arsenal (17:30) - listen on BBC Radio 5 Live
Kick-off times 15:00 GMT unless stated
Chris Sutton is making predictions for all 380 Premier League games this season, against a variety of guests.
For week 20, he takes on The Zutons frontman Dave McCabe, who supports Liverpool.
Sutton's prediction: 1-2
This is a tough one to call because while Southampton are adrift at the bottom and absolutely desperate for points, Brentford are not in great form either.
Saints' new boss Ivan Juric has been quite feisty since his appointment, and his side have only been narrowly beaten in both his games in charge.
It is noticeable how often Southampton like to lump it now under Juric, compared with their possession-based style of play under Russell Martin.
However, while it is also clear they will put up a fight I don't see much changing for them results-wise.
Brentford are a battle-hardened Premier League team, so a direct approach will not faze them, and they also have goals in their team.
The Bees are yet to win on the road this season and only picked up their first away point against Brighton last time out but, this time, I see them taking all three.
McCabe's prediction: 1-2
Brentford all day.
As we enter a new calendar year and the halfway point of the season, the Opta Supercomputer has been busy making its predictions.
But who is looking most likely to be playing their football outside the top flight next season?
It is bad news for fans of the teams who made their return to the Premier League this campaign.
According to the Opta Supercomputer's simulations, Southampton - rooted to the bottom of the table on just six points - are all but guaranteed to be playing Championship football again next term with a 99.47% chance of being relegated.
The picture is also not a rosy one for Leicester City and Ipswich Town supporters, who occupy the other two relegation spots. The Supercomputer does not see too much change there - the Foxes and the Tractor Boys having a 74.61% and 70.81% chance of relegation respectively.
It is better news for Wolves under new head coach Vitor Pereira, with Wanderers now having only a 39.21% chance of a Championship return, while Everton fans will be pleased to see they have just a 12.52% chance as they hope to see Premier League football in their new stadium next season.
Crystal Palace, West Ham and Brentford can all breathe easier with Opta predicting just a 1.68%, 0.81% and 0.72% chance of relegation respectively.
And what about Manchester United after new boss Ruben Amorim declared them to be facing a relegation battle? Well, it is good news for Red Devils fans as the chance of them actually playing Championship football next campaign is just 0.11%.
Image source, Getty ImagesBrentford scored 62 Premier League goals in 2024 but none of their first 10 goals were scored or assisted by Bryan Mbeumo or Yoane Wissa.
However, 33 of the other 52 goals in the calendar year featured either Mbeumo or Wissa involved in the goal (63%).
Brentford boss Thomas Frank has been speaking to the media before Saturday's Premier League game at Southampton (15:00 GMT).
Here are the key lines from his news conference:
Mathias Jensen, Sepp van den Berg and Mark Flekken "came through well" in their returns from injury in Wednesday's loss to Arsenal and will all be available again for selection on Saturday.
However, Fabio Carvalho "has a minor groin injury" and will likely miss the visit to St Mary's. Frank had nothing extra to add on Brentford's longer-term absentees.
The Bees boss wants to take his side's first half performance against the Gunners into upcoming games: "Except for one moment where they equalised, we played the perfect half which I'm very pleased with. We pressed aggressively high [and] we defended very compact. We were very good on the ball [and] scored a fantastic goal. That was top."
On the challenge posed by the Saints: "I watched the two games under the new manager. They have changed a bit - they don't take so many risks in build up. There's a few tactical tweaks we need to be aware of. We need to bring our A-game and be unbelievably focused."
Frank believes more wins will come soon after just one in seven games: "We are halfway through the season and have 24 points which is a good foundation to stand on. The aim is to get more away from home but we need to look into performances. In the 19 games we have played, we had one bad 90 minutes. There have been spells but overall we have been good. If we keep those performances up, we will win games."
He believes the Bees will have their "eyes wide open" in the transfer window: "I expect us to be proactive as we always are, to be out there in the market. The injury situation is what it is - the medical staff are working very hard. It's not like we need some but let's see what is happening in the next three or four weeks if players are not turned around to be able to play."
Image source, Getty ImagesWe asked for your thoughts after Wednesday's Premier League game between Arsenal and Brentford.
Here are some of your comments:
Brentford fans
Kev: Outplayed by a superior team. Compared to them we were weak at the back and created too few chances. Second half in particular completely impotent.
Ian: A game of fine margins. Some poor referee decisions and four goals. This game had it all. Brentford's season will not fall into obscurity as posted by a reporter after the game. Like all teams, Brentford have had their fair share of injuries but they get on with it. We will go again at St Mary's this Saturday.
AC: We have the most injuries in the league, and have had for about three months. So where we are in the table is fine. The defence needs strengthening so the collective level can be more easily maintained. The increase in quality provided by the summer signings is why we are not suffering like last season.
Peter: The first two goals we conceded were down to poor goalkeeping by Mark Flekken. When will Thomas Frank own up to the fact that he just isn't good enough for the Premier League? How many more games do we have to give away till the penny drops?
Arsenal fans
Tim: Comfortable victory and did not need to get out of first gear. Good to have Gabriel Jesus and Gabriel Martinelli among the goals. Big performance from Thomas Partey and the ability to rotate is an added bonus.
Kevin: We showed pure grit. After the Brentford goal, everyone kept their nerve. They are one of the hardest teams to beat at home, so if we keep this level up, the title is in our reach.
Savs: Excellent result and decent performance considering Brentford's home record and them going one up. Thought we were a bit open in the first half but the second half reminded me of last season when we were relentless. Well played Martinelli and Partey (again).
Guy: Ethan Nwaneri is a very exciting prospect. He could be exactly what we need while Bukayo Saka is out injured. I don't think we will have enough to catch Liverpool but hopefully we can cement second again. I still think we need to buy a proper striker in January.
Image source, PA MediaSince the start of last season, Brentford have lost 47 points from winning positions in the Premier League (30 last season, 17 this) - at least 10 more than any other side.
The Bees are the only side yet to keep a clean sheet at home in the Premier League this season. They have gone 11 successive home league matches without a shutout for the first time since October 2007 (13).
Brentford, West Ham and Fulham are monitoring the contract situation of 29-year-old English midfielder Will Hughes at Crystal Palace. (Football Insider), external
Want more transfer stories? Read Thursday's full gossip column
Image source, PA MediaBrentford boss Thomas Frank, speaking to TNT Sports: "I think we did a lot of things right and overall it was a good performance. The first half was extremely good and I liked the way we played - we were brave on the ball.
"We were brave under high pressure as well and overall I think we did well. The finest of margins we have to do better.
"We need to do better than one more goal. If you want to beat Arsenal we need to do everything right."
On Arsenal's set-piece threat: "I need to look more into it, but they are very good at it and it's something we need to learn from."
On the loss at home: "I think today we played a top team and you cannot expect to just beat Arsenal, but we did very well and that's the performance.
"Nottingham Forest was a bit different - I would have loved to have more from that game."
On Bryan Mbuemo possibly leaving Brentford: "Bryan was really good and I was really pleased with that.
"For me he shouldn't be a problem to hold."
Emma Smith
BBC Sport journalist at Brentford Community Stadium
Image source, ReutersBrentford are eight points off the Premier League's top five and nine above the relegation zone. Their season risks fading into obscurity.
That was what happened to them in this game - once Arsenal took the lead, the hosts never looked like getting back in the match.
While Bryan Mbeumo and Yoane Wissa are enjoying individually impressive seasons, as a unit Brentford are flagging.
Since beating Newcastle 4-2 on 7 December, they have scored just twice and have lost back-to-back home matches.
Thomas Frank must now find a way to ensure that Brentford's season does not mirror their performance in this game - strong start, poor middle, lacklustre finish.
A salve could be their next two games coming against Southampton away then Plymouth at home in the FA Cup - the sides bottom of the top two divisions.
Were you at the game or following from elsewhere?
What did you make of that display, Brentford fans?
Arsenal fans - let us know your thoughts on your side's performance
Come back to this page on Thursday to find a selection of your replies
We asked you to tell us what Brentford's New Year's resolution should be.
Here are some of your replies:
Rob: This year's resolution must be to get to the root cause of the injuries which take out so many of the squad players for so long. Is it the way we train, recover, warm up and warm down or our diet, training facilities, medical equipment and facilities? We desperately need to improve the frequency of injuries and the recovery periods. Thomas Frank needs a fit and game-ready team.
David: Add to the medical team, especially a specialist physio.
Steve: We need some fit full-backs and we need to understand why we have suffered so many injuries in the past two seasons. We should also take some time to reflect and enjoy the amazing job the whole club is doing - we are punching well above our weight.
Anna: To fix up Rico Henry and get him tearing down the left again. He was nearly back, had been involved in part of a training game and then was set back. We have been without an expert left-back for over a year now and he would have been pushing for an England call-up. We fans love him and I hope to see him back to his best. That's the dream for us all at Brentford.
Andrew: I'm in a state of deja vu from this time last year because we still need a specialist left-back, with the ongoing injury problems affecting Rico Henry and Aaron Hickey. We could even get Sergio Reguilon back on loan or, failing that, Ben Chilwell (if he is fit).
Tom: Get all of our players fit for at least one game in 2025.
Steven: We need to start winning away. If our away form was better, I think we could be challenging for the Europa League or Conference League.
Katie Stafford
BBC Sport journalist
Image source, Getty ImagesIt has been another entertaining year in the Premier League, so with 2025 just a matter of hours away let's take a look at the clubs that have topped the charts.
Manchester City became history makers in 2024 as they sealed their fourth successive Premier League title in May and their sixth in seven seasons.
Pep Guardiola's possession based football continued to dominate as they maintained the ball for an average of 64.5% per game and had a 90.6% passing accuracy over the year.
Brighton were the closest to matching their accuracy at 87.5% and Ange Postecoglou's similar high-risk football saw Tottenham retain 61.3% possession.
Under Jurgen Klopp and new head coach Arne Slot, Liverpool scored 92 goals in 2024 which is three more than Arsenal and nine greater than City.
The Reds registered 741 shots in total, which is a stark contrast to Leicester City who recorded the least with 170. Albeit that is only since their promotion back to the top-flight in the summer.
Of those shots, 286 of Liverpool's were on target. But it is Thomas Frank's Brentford that have proven to be the most clinical.
The Bees had a conversion rare of 15.3% after scoring 62 goals in the Premier League. Yoane Wissa found the back of the net 17 times, while Bryan Mbuemo registered 12 goals.
From goal scoring to conceding - West Ham turned over the most goals with 79.
They should look to North London for tips on how to tighten up their defence as Arsenal proved to be the most solid across all aspects of their back line.
The Gunners conceded just 25 goals across the course of the year and kept an impressive 18 clean sheets.
Sean Dyche's Everton, renowned for being stubborn to break down, kept 14 clean sheets despite only winning eight of their 36 games.
All stats are supplied by Opta
Chris Sutton is making predictions for all 380 Premier League games this season, against a variety of guests.
This week, he takes on musician Emma-Jean Thackray, who is a Leeds fan.
Sutton's prediction: 0-1
I am worried about Arsenal without Bukayo Saka, who has been ruled out for more than a couple of months.
On top of that, Brentford away is obviously a very tough test when you consider how phenomenal the Bees have been at home this season.
But I am backing the Gunners to run Liverpool close in the title race this season and, because of that, I am going with them to win this game, somehow.
Emma-Jean's prediction: 1-1
Something is telling me this is not going to be a good watch, it could be quite stodgy. Most of my friends are Arsenal fans so I hope they don't give me any stick for this prediction, but I am going for a draw.
Brentford boss Thomas Frank has been speaking to the media before Wednesday's Premier League game at home against Arsenal (kick-off 17:30 GMT).
Here are the key lines from his news conference:
Frank confirmed that Christian Norgaard "can play", while Sepp van den Berg and Matthias Jensen will also be in the squad. However, Ben Mee will be out for "a couple of weeks" with a muscle problem and Mark Flekken will be assessed on Tuesday.
On if injuries mean Bees will need to be active in the January transfer window: "We will assess it. We have got a plan for every scenario that can happen. We will be ready to act if we need to. I have said many time we have a very strong squad when everyone is fit and available. We won't do anything early, but if it doesn't improve in the next month then we might need to do something."
On what he would say to those interested in trying to sign Bryan Mbeumo: "In January? I would say good luck. We love Bryan. He loves playing here. He has had a fantastic season so nothing will happen."
The Brentford boss still believes that Joao Pedro's attempted elbow on Yehor Yarmoliuk in their last match should have received a red card, but accepted: "Mistakes happen from the referee and VAR and everyone is very focussed on trying to improve things. Howard Webb and his team want to do everything to improve it so hopefully there will be improvements going forward."
Frank said it has been a "good year for everyone involved in the club and for every Brentford fan" as they try and "find the balance" between being happy for every year they are in the Premier League but still having "ambitions to do more".
He therefore sets achievable and incremental targets: "To have layers, to develop the team and club, to play some interesting football, develop players and people and keep moving forward. I think we do that. There have definitely been more ups than downs this year so I am pleased with that."
On how it would feel to kick-off 2025 with a win over Arsenal: "It would be amazing. That is the aim - to do what we can to try and win the game. We are facing a very good Arsenal team. In a way, they have gone a little under the radar. There has been much talk about Manchester City, [Manchester] United, Liverpool because they are doing fantastic and Chelsea as they have done more than people expected, but I think Arsenal have performed consistently well. A well run machine and team."
Christmas is boxed off.
We're almost through the confusing days before New Year and January is within touching distance.
And we need your help - what is Brentford's New Year's resolution?
It could be a new player to sign, a tactical system to implement, an off-the-pitch matter or something else entirely.
Image source, Getty ImagesWe asked for your thoughts after Friday's Premier League game between Brighton and Brentford.
Here are some of your comments:
Ian: Another statistical triumph but only one point gained. We need to be more dynamic rather than trying to work a perfect goal. We end up toothless in the box in terms of striking at the opponent's goal and rarely take a chance from long range.
Washy: Frustrating! We generally played OK, but seemed to slow our play down when we got to the edge of their box, allowing them to get organised and close down the space. Julio Enciso missed a few, but at least he had a go. Good to see Solly March back.
Bill: Since Danny Welbeck has been injured, the forwards couldn't hit the goal if they were twice the size!
Sarah: We headed to Amex Stadium quietly confident we would end our bad run. The first half looked promising, especially when they lost their goalkeeper too; we had most of the possession and were passing well, then it all fell apart. Again and again, we had the ball, in the box but missed opportunities to shoot, preferring to pass out to the right. I have no idea why, unless lack of confidence to score. On the final whistle, their goalie celebrated the 0-0 scoreline - Brighton fans were not so happy!
Brentford fans
George: While few neutrals will be clamouring to watch the highlight-reel of a 0-0 draw compared to our usual home game fireworks, this performance was exactly what our fans needed. We were resolute and focussed defensively against an away team that, quite frankly, is a more successful version of ourselves in terms of its financial and managerial mindset.
Mitch: Absolute heroes this evening. Every player gave every piece of energy in their bodies. Could have nicked it, but happy with a point.
David: What a fantastic match. So frustrating to not score on any of the brilliant counter-attacks, injuries worrying as always, but some standout performances with Mikkel Damsgaard man of the match.
Matt: Accomplished performances from the back-up players but the fact we have a starting XI in the physio room is by far our biggest concern. Another point on the board but with our run of fixtures there won't be too many more in the next few weeks.
