Highlights and analysis from Sunday's two Premier League fixtures, plus the best of the action from the rest of the weekend.
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Joe Rindl
BBC Sport journalist
Image source, Getty ImagesRuben Amorim's injury-hit Red Devils have lost three of their past four league games and drop to 15th - 12 points clear of the relegation zone.
This week, Amad Diallo, their top scorer in the league, was ruled out for a long spell with an ankle injury, while Kobbie Mainoo, Manuel Ugarte and Toby Collyer also picked up knocks on the training ground.
With Christian Eriksen and Leny Yoro both missing the match through illness, Amorim was forced to hand veteran midfielder Casemiro his first start since 30 December, and the 32-year-old was often exposed against Maddison, Son and Tel.
Meanwhile, all the players on United's bench, except 30-year-old Victor Lindelof, were teenagers who had not made a first-team appearance for the club.
Amorim did not make a substitution until the 90th minute when 17-year-old striker Chido Obi replaced Casemiro for his United debut.
Still, United had plenty of talent on the pitch and should have equalised when Bruno Fernandes played in Garnacho before the break only for the Argentine to blast well over the bar.
Garnacho had a one-on-one saved by Vicario in the second half, while Joshua Zirkzee headed Noussair Mazraoui's cross narrowly wide from a good position in the closing stages.
An equaliser wasn't to be.
Defeat was United's 13th of the season in all competitions and their ninth since Amorim took charge in November.
Image source, Getty ImagesManchester United defender, Matthijs de Ligt to Sky Sports after today's loss: "If you lose it's never enough. We can speak about the personal problems, the injuries, but Tottenham have the same problems. If you lose, it is never enough.
"We played OK and created some chances. But if you lose 1-0, you didn't score and conceded one, so we needed to improve at both ends.
"I think the urgency, the hunger to score, that is something that may be lacking. That's not only on the attackers, it's also on the midfield and the defenders. It's a team thing and we definitely need to improve."
On their confidence: "I think you can say [it] has taken a real hit. Especially in the Premier League, if you lose the confidence you lose the game.
"We still had a starting XI with first-team players. It's no excuse. It's not nice when you lose five players in one week, but that's part of football, part of life.
"I believe you have to deserve fortune. At the moment, apparently we don't deserve it. I don't believe in fortune coming out of nowhere."
Image source, Getty ImagesManchester United manager Ruben Amorim has been speaking to BBC Match of the Day after today's defeat: "It was the difference of the game, they scored and we didn't. We had the opportunities. We had situations in transitions, trying to get a result, but in the end they scored and we didn't.
"We want to recover the players, I think we can recover some players for the next game. We have to be together to finish the season and start over."
On the young players on his bench: "It is the hardest competition in the world. I am trying to be careful with them. I felt the team was pushing for the goal and I felt I don't want to change. But they will play.
"You try to read the game, understand what you see in training. The team were pushing for the goal and I didn't feel the need to change.
"I am not worried. I understand our fans, what the media think about it. I hate to lose, that feeling is the worst.
"The rest I am not thinking about. I am here to help my players. I understand my situation, my job, I am confident on my work and I just want to win games.
"The place in the table is my worry - I am not worried about me."
Image source, Getty ImagesTottenham are the first side to win three separate games against Manchester United in a single season in all competitions since Chelsea in 2012-13. Spurs have also completed a league double over the Red Devils for the first time since 1989-90 under Terry Venables.
Manchester United have lost 12 of their 25 Premier League games this season, their most defeats from their first 25 matches of a league campaign since 1973-74 (13) – when they were last relegated from the top-flight.
Were you at the game or following from elsewhere?
Have your say on Tottenham's performance
What did you make of Man Utd's display?
Come back to this page on Monday to find a selection of your replies
Two matches make up Sunday's Premier League action and BBC Sport will bring you every kick.
Liverpool v Wolves (14:00) - follow the action here
Tottenham v Manchester United (16:30) - follow the action here
Trying to call this is a bit like a game I used to play with my kids, poker dice, where you roll five dice and it is completely random what you end up with.
This is the first time I have so little idea of what to expect from both sides that I actually think I need to make two predictions, rather than one.
I can guarantee you this, though. Whatever result I go for, it will end up being the opposite of what actually happens.
Tottenham demolished Manchester United 3-0 at Old Trafford in September but that does not really have any bearing here.
Spurs are getting players back from injury and Timo Werner, James Maddison and Guglielmo Vicario are among those training again, but how fit are they going to be for this game?
Ange Postecoglou says his players are out on their feet and we could see that in their FA Cup defeat at Aston Villa, so a lot depends on how much they have left in the tank.
As for Manchester United, well I've been reading reports this week that some of their players are unhappy with Ruben Amorim's style of play.
There is lots going on off the pitch too, with stories that more redundancies are planned at the club, following controversy over a rise in ticket prices.
Who would have thought when Ineos completed their deal to take a stake in United 12 months ago that, within a year, they could possibly be as unpopular with fans as co-owners the Glazers are.
In regards to Amorim, I just think he needs time. He arrived in mid-season, he has his way of playing and United will have to give him the players who fit that system, so it might take a window or two before we see him with the team he wants.
There needs to be patience there, but we also know football fans are impatient. They want to see some improvement in the short-term, and it is hard to argue they have made any progress since Amorim took charge.
I still have a sneaky feeling they might edge this game but I cannot really tell you what I am basing that on.
This is a big game for Ange too, now his side are out of both domestic cups, but I am going with United, just.
Sutton's prediction: 1-2 or 4-0 [only 1-2 will count as Chris's score]
Sitting 14th and 13th in the Premier League in February is not where either Tottenham or Manchester United would have expected to be at this stage of the season.
But inconsistent form and injuries means the two clubs meet at Tottenham Hotspur stadium on Sunday with few being able to say with any certainty who might come out on top.
While the two sides go head-to-head on the pitch, we asked our fan writers for each club to go head-to-head off it.
Each got to ask three questions of the other. Tottenham fan Anna Howells from Spurs XY, external was asked the following by our United supporter:
Ange Postecoglou is under intense pressure at the moment. Are you backing him or is it time for Tottenham to hire yet another manager?
After crashing out of the Carabao Cup and FA Cup, what are your objectives for the rest of the season?
What scoreline are you predicting against Manchester United on Sunday?
Manchester United fan contributor Dale O'Donnell from United In Focus, external was given the following questions:
Ruben Amorim is having a tough time, so are you convinced he is the manager to restore past glories?
Do the fans want Amorim to prioritise the FA Cup over the Premier League and Europe?
Given the search for a striker and the aging midfield, which area or areas of the pitch is the priority for United in the summer ?
Simon Stone
Chief football news reporter
Image source, Getty ImagesIt emerged this week that Manchester United board member Sir Dave Brailsford has told club staff about a 'Mission 21' to go alongside its 'Project 150'.
The idea is to tie in a 21st league title with the celebrations to mark Manchester United's 150th anniversary in 2028.
On current evidence, getting that figure in the space of three years is going to be a tough task.
Head coach Ruben Amorim knows the demands of the club, without even needing to go into specifics around if he has been told about 'Mission 21' or 'Project 150' in the discussions he had with the club's chiefs before taking the job.
But he can offer no guarantees about achieving it.
"I said from day one our focus is to win the Premier League," he said. "But I don't know how long it will take.
"We are in a difficult situation but we can change everything in a few years."
Image source, Getty ImagesManchester United boss Ruben Amorim believes he has "bigger pressure" on him than Tottenham counterpart Ange Postecoglou.
The pair come face to face on Sunday in a mid-table Premier League battle with both teams struggling for consistency this season amid injuries and poor form.
Despite this, both managers have insisted on sticking with their footballing philosophies and received criticism for doing so.
"I am a huge fan of Ange Postecoglou. I am from a different culture. All the Portuguese coaches can adapt," Amorim said.
"I adapt. I use one system because I believe if you do that system, you can then use other systems at the same time - that is my idea.
"But, we are not winning games and I understand the connection with me and Ange - we have the same problems. With all due respect, I am at a bigger club, with bigger pressure. It is important for a coach to follow his principles.
"Of course [I have sympathy with him], especially because he is a good guy, a good coach and he wants to play football in the right way.
"When we choose this profession there is a lot of good things, but then you feel that pressure when you don't win."
Postecoglou, meanwhile, backed the United head coach, who replaced Erik ten Hag earlier in the season, to improve the Manchester club.
"I have respect for all managers because I know how tough it is to do the job. Ruben is just doing what he wants to do," the Spurs boss said.
"Manchester United have scouted him and identified him by looking at the way he does business. You bring him in with a purpose.
"If United stick with Ruben for two years then they will see progress - absolutely, because it's how long it takes.
"If anyone believes anything can change in a short space of time, they are living in a alternative universe that is not based on reality."
Image source, Getty ImagesEarlier, we asked you to name the former Manchester United manager from a series of clues.
The answer was David Moyes, who was in charge between 2013 and 2014.
Image source, Getty ImagesManchester United's match at Tottenham will retain some of its usual stature because of their status - but a glance at the Premier League table means it should also be an embarrassment to both clubs.
A fixture that is usually fought out near the top has been reduced to a lower mid-table clash that is a graphic illustration of the struggles both have had.
United head coach Ruben Amorim acknowledged they got a huge slice of luck when Harry Maguire's clearly offside goal gave them victory in the FA Cup fourth round against Leicester City at Old Trafford.
Amorim, with the brutal honesty that has become his trademark, admitted United were "poor", even in advancing to the next round, where they will host Fulham.
He will be hoping to take advantage of Spurs' own woes, but first United must deal with their own difficulties since Amorim arrived.
These include a struggle to adapt to his preferred three-man defensive system and such a chronic lack of quality up front that he preferred to use teenage midfielder Kobbie Mainoo there in preference to expensive strikers Rasmus Hojlund and Joshua Zirkzee in United's last league game, a 2-0 home defeat by Crystal Palace.
Nicola Pearson
BBC Sport journalist
Manchester United boss Ruben Amorim has been speaking to the media before Sunday's Premier League game at Tottenham (kick-off 16:30 GMT).
Here are the key lines from his news conference:
Amorim would not reveal names but confirmed they "don't have players back" because of setbacks and there are "one or two issues", alongside one player suffering with illness.
On the importance of game against 14th-placed Tottenham: "Every game from now until the end of the season is a big game for us. We need to improve the way we play football - but especially we need to win. No matter what, we need to win and to do that we need to improve the way we play football."
The United boss said he is "a huge fan of Ange Postecoglou" and admitted they "have the same problems", but added: "With all due respect, I am at a bigger club, with bigger pressure. It is important for a coach to follow his principles."
On whether he and the team feel that pressure: "I feel it in the performance. Sometimes when we are a bit the underdog - and that is a bit we should not feel in any game because we are Manchester United - I feel the players are more free. We have to be more dominant in every aspect and I feel we are not there. Sometimes the feeling is different when you play away."
On whether it is dangerous to feel "safe" at this stage of the season: "It is impossible. If you see the table, it is impossible to feel comfortable in this moment."
He added: "We just want to win and to improve our performance because we are Manchester United. We are always talking about the same thing. We need to win the next game, we need to improve, we need to perform better. There is no comfort in any situation in this club."
Amid reports of more redundancies at the club, Amorim said his "biggest problem now is Tottenham". However, he added: "I have to understand all these problems but that problem of our club is not new. We already knew all the rules of [financial] fair play. We have a problem at the moment, but that cannot change the way I coach the team and prepare the team."
Full commentary of Tottenham v Man Utd on BBC Radio 5 Live from 16:30 on Sunday
Follow all Friday's Premier League news conferences and the rest of the day's football news
