Unfamiliar territorypublished at 01:05 Greenwich Mean Time 14 January
Miami Dolphins @ Kansas City Chiefs (01:10 GMT)
Incredibly, with the Chiefs finishing as third seeds in the AFC it's the lowest Patrick Mahomes has ever finished in his career, as he's previously led the team to one of the top two seeds.
That's why the Chiefs have played 14 straight play-off games at home at Arrowhead Stadium, but if they win there they'll likely have to go on the road for the first time in the Mahomes era.