Southern Brave opened their Hundred campaign with a six-wicket win over London Spirit, despite Beth Mooney's sublime 97 not out.
Spirit captain Charlie Dean chose to bat first and Mooney's led her side to 155-4.
It looked a competitive score at the halfway stage but England opener Danni Wyatt smashed 65 from 34 balls as Brave made light work of the chase.
Sophia Dunkley saw her side home with a steady 34 not out as they reached their target with six balls to spare.
It was the highest successful chase in the women's Hundred, with last year's runners-up Brave setting out an early warning of their batting power to the rest of the competition.
Here's what else happened:
Amelia Kerr made 37 from 27 balls in a key partnership of 87 with Mooney.
Australia leg-spinner Amanda-Jade Wellington took three wickets for Southern Brave.
Wyatt and India's Smriti Mandhana added 62 for the first wicket in Brave's chase.
17-year-old Freya Kemp smashed two sixes in her 14 not out, including one to wrap up victory.
What's next?
London Spirit will be looking to bounce back from defeat as they take on Northern Superchargers, who also lost their first game, at Headingley on Sunday.
Southern Brave play Oval Invincibles on the same day in a repeat of last year's final, with both teams looking to make it two wins from two.
Post update
Here are the best shots from Danni Wyatt's innings. She set the Brave on their way to a record run chase.
'Mooney was outstanding' - Shrubsole
Southern Brave captain Anya Shrubsole: "Credit to Beth Mooney she was outstanding and as a captain and bowler she makes you feel like you haven't got a clue about where to put your fielders. Danni [Wyatt] was brilliant with the bat.
"We thought the score was probably about par. It felt like a really good track. It was a good score from them but it felt like if a batter got in it was near on impossible to get them out. We know we've got a powerful batting line-up who can do some damage.
"Tahlia [McGrath] will come in on Saturday and maybe apart from Beth Mooney she is the form batter in T20 cricket. The depth allows Danni and Smriti [Mandhana] to attack.
"Freya Kemp was saying it was going to be slower balls so she was going to go out and whack it and we were like 'Yeah, ok Kempy' and thought she might have a look at one, but she just went for it. She is a great talent."
Post update
The men's match between the two starts at 18:30 BST. You will be able to follow that match here.
'My job is to be brave and fearless'
Southern Brave opener Danni Wyatt to Sky Sports: "Yeah it was a really nice wicket out there. I'm really happy to contribute to a win and really pleasing to get a win on the board.
"My job is to just go out there and be brave and fearless and if it is in my area to go for it. It was a quick outfield so I really enjoyed being out there today.
"I'm trying to get a bit stronger in the gym but with T20 and Hundred you've just got to know your game, pick your bowlers and know your strength.
"Beth Mooney batted exceptionally and we knew it was going to take one of us to do what she did. The bowlers bowled exceptionally well to get them to get that target."
Post update
You've got to feel for Beth Mooney. She hit 97 not out - the highest women's score in a Hundred match - but still lost.
She doesn't even win the Match Hero award. That has gone to Danni Wyatt for her 65 from 34 balls in Brave's chase.
Post update
Emily Windsor
Oval Invincibles batter on BBC Test Match Special
Southern Brave didn't even have Tahlia McGrath playing today so they've still got strength to add to this side.
Post update
It's all hugs and high fives on the Brave bench. They were the best team the group phase last year but went and lost the final.
They have made an imposing start this time around.
Post update
Melissa Story
BBC Radio
Listen to the celebrations around the Ageas Bowl!
BreakingSouthern Brave win by six wickets
But this time Freya Kemp thumps a six over the bowler's head.
Southern Brave have pulled off the highest chase in the women's competition with ease.
Brave 153-4
Not this time. A dot ball - no runs are scored...
Brave 153-4
Need three runs to win
A single to Dunkley. Can Kemp win it with a boundary?
Brave 152-4
Dunkley wants this done quickly! Charlie Dean is in for another bowl but her first delivery is heaved away.
The Brave are a hit away.
Post update
BBC SportCopyright: BBC Sport
Brave 148-4
Need eight runs to win
it's good, tight bowling from Schutt but it's wickets the Spirit need at this stage.
This record run-chase is almost complete.
Brave 146-4
Need 10 more runs to win
Kemp now steals a clever single, up against the bowling of Megan Schutt.
Sophia Dunkley is the experienced batter here and she has only just turned 24. The kids are good.
Post update
Melissa Story
BBC Radio
Cricket is a pretty simple game for Freya Kemp isn't it? It is just see ball hit ball with her.
Brave 144-4
Need 12 runs to win
What a way to start! Freya Kemp, on her Hundred debut, launches her first ball for six.
She's 17 years old. Seventeen!
Post update
16 balls to go. 18 runs needed.
Here's Freya Kemp...
Post update
Emily Windsor
Oval Invincibles batter on BBC Test Match Special
That keeps London Spirit in the game. If they can pick up a couple more wickets then the panic will set into the Brave changing room.
Live Reporting
Matthew Henry and Ffion Wynne
All times stated are UK
-
Amelia Kerr made 37 from 27 balls in a key partnership of 87 with Mooney.
-
Australia leg-spinner Amanda-Jade Wellington took three wickets for Southern Brave.
-
Wyatt and India's Smriti Mandhana added 62 for the first wicket in Brave's chase.
-
17-year-old Freya Kemp smashed two sixes in her 14 not out, including one to wrap up victory.
BBC SportCopyright: BBC Sport 
Latest PostSouthern Brave win despite Mooney heroics
Southern Brave opened their Hundred campaign with a six-wicket win over London Spirit, despite Beth Mooney's sublime 97 not out.
Spirit captain Charlie Dean chose to bat first and Mooney's led her side to 155-4.
It looked a competitive score at the halfway stage but England opener Danni Wyatt smashed 65 from 34 balls as Brave made light work of the chase.
Sophia Dunkley saw her side home with a steady 34 not out as they reached their target with six balls to spare.
It was the highest successful chase in the women's Hundred, with last year's runners-up Brave setting out an early warning of their batting power to the rest of the competition.
Here's what else happened:
What's next?
London Spirit will be looking to bounce back from defeat as they take on Northern Superchargers, who also lost their first game, at Headingley on Sunday.
Southern Brave play Oval Invincibles on the same day in a repeat of last year's final, with both teams looking to make it two wins from two.
Post update
Here are the best shots from Danni Wyatt's innings. She set the Brave on their way to a record run chase.
'Mooney was outstanding' - Shrubsole
Southern Brave captain Anya Shrubsole: "Credit to Beth Mooney she was outstanding and as a captain and bowler she makes you feel like you haven't got a clue about where to put your fielders. Danni [Wyatt] was brilliant with the bat.
"We thought the score was probably about par. It felt like a really good track. It was a good score from them but it felt like if a batter got in it was near on impossible to get them out. We know we've got a powerful batting line-up who can do some damage.
"Tahlia [McGrath] will come in on Saturday and maybe apart from Beth Mooney she is the form batter in T20 cricket. The depth allows Danni and Smriti [Mandhana] to attack.
"Freya Kemp was saying it was going to be slower balls so she was going to go out and whack it and we were like 'Yeah, ok Kempy' and thought she might have a look at one, but she just went for it. She is a great talent."
Post update
The men's match between the two starts at 18:30 BST. You will be able to follow that match here.
'My job is to be brave and fearless'
Southern Brave opener Danni Wyatt to Sky Sports: "Yeah it was a really nice wicket out there. I'm really happy to contribute to a win and really pleasing to get a win on the board.
"My job is to just go out there and be brave and fearless and if it is in my area to go for it. It was a quick outfield so I really enjoyed being out there today.
"I'm trying to get a bit stronger in the gym but with T20 and Hundred you've just got to know your game, pick your bowlers and know your strength.
"Beth Mooney batted exceptionally and we knew it was going to take one of us to do what she did. The bowlers bowled exceptionally well to get them to get that target."
Post update
You've got to feel for Beth Mooney. She hit 97 not out - the highest women's score in a Hundred match - but still lost.
She doesn't even win the Match Hero award. That has gone to Danni Wyatt for her 65 from 34 balls in Brave's chase.
Post update
Emily Windsor
Oval Invincibles batter on BBC Test Match Special
Southern Brave didn't even have Tahlia McGrath playing today so they've still got strength to add to this side.
Post update
It's all hugs and high fives on the Brave bench. They were the best team the group phase last year but went and lost the final.
They have made an imposing start this time around.
Post update
Melissa Story
BBC Radio
Listen to the celebrations around the Ageas Bowl!
BreakingSouthern Brave win by six wickets
But this time Freya Kemp thumps a six over the bowler's head.
Southern Brave have pulled off the highest chase in the women's competition with ease.
Brave 153-4
Not this time. A dot ball - no runs are scored...
Brave 153-4
Need three runs to win
A single to Dunkley. Can Kemp win it with a boundary?
Brave 152-4
Dunkley wants this done quickly! Charlie Dean is in for another bowl but her first delivery is heaved away.
The Brave are a hit away.
Post update
Brave 148-4
Need eight runs to win
it's good, tight bowling from Schutt but it's wickets the Spirit need at this stage.
This record run-chase is almost complete.
Brave 146-4
Need 10 more runs to win
Kemp now steals a clever single, up against the bowling of Megan Schutt.
Sophia Dunkley is the experienced batter here and she has only just turned 24. The kids are good.
Post update
Melissa Story
BBC Radio
Cricket is a pretty simple game for Freya Kemp isn't it? It is just see ball hit ball with her.
Brave 144-4
Need 12 runs to win
What a way to start! Freya Kemp, on her Hundred debut, launches her first ball for six.
She's 17 years old. Seventeen!
Post update
16 balls to go. 18 runs needed.
Here's Freya Kemp...
Post update
Emily Windsor
Oval Invincibles batter on BBC Test Match Special
That keeps London Spirit in the game. If they can pick up a couple more wickets then the panic will set into the Brave changing room.