Never mind cotton wool, Jack Wilshere will be wrapped up in a big coat as he's only on the bench for Bournemouth.

West Brom pitch record signing Nacer Chadli into the action from the off. 

Arsenal hand debuts to deadline day signings Lucas Perez, a forward, and Shkodran Mustafi, a defender.

Simone Zaza makes his West Ham debut, while Dimitri Payet makes his first start of the season. No Sofiane Feghouli again.

Stoke hand debuts to Wilfried Bony and Bruno Martins Indi while Hugo Lloris is back for Spurs. 

Trevor Sinclair
Former England winger on Football Focus

Image source, PA

Jack Wilshere is a short, powerful athlete. He's the kind of player who picks up injuries in training, so you have to wrap him in cotton wool and get him right for Saturday. 

But let's get it right, he's one of the best central midfielders in England.

Almost time for team news then...

Aaron Cresswell
West Ham full-back on Football Focus

The facilities are fantastic, but the gaffer got us together before the season and said this new stadium does not put a point on the board. It will be different to Upton Park on a Tuesday night, so we’ll have to work hard.  

Football Focus

Image source, Getty Images

West Ham co-chairman David Sullivan on Football Focus: "The atmosphere here is better than anyone expected, and yes it is different but you cannot live in the past. You have to look forward and it has put us on another level. The players have to put in the performances on the pitch, and the manager has to gel the side, but we have to look forward.

"Nobody knows what will happen this season, Leicester smashed the old order last year, Southampton finished top six, we were seventh – can that continue or will the old order be re-established this season? Nobody knows."

John Motson
BBC commentator

Image source, AP

The signings of Shkodran Mustafi and Lucas Perez should ease some of the pressure on Arsene Wenger.

Mustafi has been earmarked to partner Laurent Koscielny at centre-back, but it's not so clear whether Perez's future lies at centre-forward or on the flank.

Southampton have not got off to the best of starts under Claude Puel. They will be expecting a lot from Nathan Redmond and fellow summer signing Sofiane Boufal, although the latter arrives short of full fitness.

With the top three off to perfect starts and already looking impressive, Arsenal need to put together a winning run just to stay in contention.

They cannot afford to drop points at home - even against a Southampton side that has finished seventh and sixth in the last two seasons.

Plenty of football for you to listen to and watch on the BBC today (all times BST).

Right now - Celtic v Rangers, BBC Radio 5 live sports extra

Right now - Manchester United v Manchester City, BBC Radio 5 live 

15:00-17:00, Arsenal v Southampton, BBC Radio 5 live (build-up from 14:30)

16:15-17:10, Final Score, BBC One (14:30-17:30, BBC Red Button and online) BBC One NI coverage ends at 17:00 (Sportscene on BBC One in Scotland). 

18:06-20:00, 606, BBC Radio 5 live

22:50-00:20, Match of the Day, BBC One

Only Arsenal (27) and Man Utd (25) have kept more Premier League clean sheets than West Brom (23) since Tony Pulis took charge in January 2015.

But Pulis' side have scored just seven goals in their last 13 Premier League games.

Image source, Getty Images

A transfer that you may have missed - coming as it did after the close of the window - was Crystal Palace landing former Arsenal midfielder Mathieu Flamini on a contract until the end of the season.

Flamini, 32, left the Gunners this summer having made 246 appearances over two spells and winning three FA Cups.

The Frenchman, who also won the Serie A title in 2011 during five years at AC Milan, is Palace's fifth permanent signing of the summer.

Meanwhile, loan signing Loic Remy has been ruled out for a number of weeks with an ankle injury.

Image source, PA

We should have team news for the six 15:00 BST kick-offs with you in the next 25 minutes or so. A few deadline day debutants to come in? 

In League One, leaders Bolton host MK Dons and second-placed Bradford face a tough trip to Gillingham. Game of the day sees Oxford host rivals Swindon Town in a sell out at the Kassam Stadium. 

League Two table toppers Luton play host to Grimsby while surprise strong starters Morecambe face promotion hopefuls Doncaster. Bottom-of-the-table Cambridge United face a tough trip to third-placed Plymouth.

Image source, get

Arsenal haven't lost in 21 home league games against Southampton (W15 D6), last losing back in November 1987 (0-1, thanks to Danny Wallace's goal).

Image source, Getty Images

The Chinese family behind the failed takeover of Hull City remain "seriously interested" in buying the club.

An agreement to sell to a group led by Dai Yongge and Dai Xiu Li fell through amid reports that they did not meet the Premier League's owners' test.

But Li told the Daily Mail:, external "We still want Hull City and our ambition is to build the club and make it one of the strongest in England."

The consortium paid a seven-figure deposit before the deal collapsed.

The Hull Daily Mail , externalreports the sum paid was around £6m and the consortium's period of exclusivity is now over. At least one other consortium is interested in opening negotiations, the newspaper adds.

It's all going swimmingly well for Huddersfield in the Championship so far, and the early league leaders will be looking for another fine day away at local rivals Leeds this afternoon.

Could a camping expedition be behind their success? Here'e what happened when Football Focus met Huddersfield boss David Wagner, who reveals how a pre-season spent in the wilderness of Sweden helped his players make a great start to the new Championship campaign.  

Today's fixtures:

Brighton v Brentford

Fulham v Birmingham

Leeds v Huddersfield

Norwich v Cardiff

Preston v Barnsley

QPR v Blackburn

Rotherham v Bristol City

Sheff Wed v Wigan

Wolves v Burton

Derby v Newcastle 

Image source, Reuters

I'm sure you are across them - in which case you won't be reading this - but both early kick-offs have been as action packed as you'd hope.

In Scotland, it's Celtic who are 3-1 up on rivals Rangers with half an hour to go. Follow that game in full here.

And at Old Trafford, Manchester City looked magnificent for 40 minutes and went 2-0 up, but a huge error from Claudio Bravo on his debut allowed Zlatan Ibrahimovic to strike back for United. 2-1.

Follow that game here. 

Tony Husband
BBC commentator

Image source, PA

Commentators are fortunate enough to see the team sheets at Premier League games precisely 75 minutes before kick-off.

As the camera phones click, two names will be on everyone's minds - Jack Wilshere and Nacer Chadli.

Much of the credit for Wilshere's stunning loan move has gone to Eddie Howe. It's no surprise that the Bournemouth boss continues to turn heads in the game but he'll be more focused on getting a first league win.

A protracted takeover seems to have rocked the sturdy foundations Tony Pulis has built at West Brom. If record signing Chadli and other new faces like Hal Robson-Kanu can make an impact, Baggies fans will rediscover some hope.

If the game matches the stories surrounding it, it should be a good one.

Here's some more from Arsene Wenger on the future of Jack Wilshere. Who definitely has a future at Arsenal. Definitely.

Maybe. Possibly?