Alcacer scores twice and Ramos - booed by home crowd - heads in
Sub Bartra adds fourth in second half
Vokes heads in late consolation for Wales
First Wales game at Principality Stadium since 2011
Bale misses match with groin injury
Wolves' Jonny comes on for Spain debut
Live commentary on BBC Radio 5 live
That's all from me today.
You can read Dafydd Pritchard's full match report on Wales' heavy defeat to Spain and Scotland's 'shambolic' defeat to Israel.
You can also read our preview on England's Nations League match with Croatia tomorrow evening.
And make sure you rate the players from this match in Wales.
Catch you tomorrow!
France 2-2 Iceland
All over in France. What a comeback! It was all about that man Kylian Mbappe.
FT: Wales 1-4 Spain
Wales manager Ryan Giggs speaking to Sky Sports: "The disappointment for me was in the basics. You have to do that even against the average teams.
"If you don't do the basics against a very good team you're in trouble. You have to do the right things or you will get punished. There were so many mistakes.
"Spain move the ball quickly and have penetration. We knew we were up against a good team.
"We showed some threat going forward in the end and that's what we wanted to do. That's about all we can take out of this game - the goal.
"The good thing about football is you always have the next game. We have to react in a positive way in what will be another tough game, and be better."
On Gareth Bale returning for next game: "It's unlikely at this point. It's nothing serious but the closer we get to the game, we will have to make a decision."
Image source, Getty ImagesDRAMA!!!
Kylian Mbappe (90 mins)
Well, well, well. France have clawed this game back from the brink.
Les Bleus have a golden opportunity from the penalty spot after Iceland are penalised for a handball.
Kylian Mbappe steps up... boom! Smashes it into the top left-hand corner. Never in doubt from the boy wonder.
Image source, gettHolmar Orn Eyjolfsson (OG)
Game on? Kylian Mbappe, predictably, is the architect as he flicks his way past his marker in the box before drilling a shot that the Iceland keeper can only parry onto defender Holmar Orn Eyjolfsson and into the net. Oh.
Heading towards the 90...
Image source, Reuters#bbcfootball
Matthew John: Very tough but was a friendly so nothing much but at least Wales scored. But great night of football. Unlucky to Wales.
Poland 2-3 Portugal
Bernardo Silva has been in sparkling form for Manchester City this season and tonight he's proved to be the matchwinner for his nation.
The Portugal attacking midfielder's stunning solo goal proved the difference between his team and hosts Poland.
Meanwhile, Serbia wrapped up a 2-0 win over Montenegro in the first meeting between the two nations since they divided in 2006.
In the other Nation League matches, Romania won 2-1 against Lithuania, Azerbaijan beat Faroe Islands 3-0 and Kosovo triumphed 3-1 against Malta.
Image source, Getty ImagesFT: Wales 1-4 Spain
Wales midfielder Aaron Ramsey speaking to Sky Sports: "We gave them far too much space to play but we managed to get hold of the ball a little bit better at the end.
"The first half an hour we were quite poor and couldn't get to grips with them. It was a tough night and one we will learn from.
"They were tough opposition and we were punished."
Wales goalscorer Sam Vokes: "It's always nice to get on the score-sheet. We were much better in the second half and looked more organised.
"We were always fighting back after the first half an hour but we will learn. Spain are top class. We knew that from the start.
"We let ourselves down in the first half and it was an uphill battle from there."
Image source, Getty ImagesFT: Wales 1-4 Spain
What about this guy? David Brooks has been ripping it up for Bournemouth in the Premier League this season - scoring twice in seven appearances - and tonight he bagged himself an assist on just his sixth international cap.
Image source, Getty ImagesFrance 0-2 Iceland
France are turning up the heat - but Iceland aren't melting. Kylian Mbappe twists and turns in the box but can't get his shot past a wall of away defenders. About fifteen minutes for the world champions to break down the visitors. Twice.
Israel 2-1 Scotland
A frustrating night for the Scots. Their first-half lead was squandered after John Souttar was sent off before an own goal from Kieran Tierney gave Israel victory.
Reaction to that result can be found here.
Image source, Getty ImagesWales 1-4 Spain
Guillem Balague
Spanish football journalist on BBC Radio 5 live
Rodri, the new Sergio Busquets, impressed the most.
He moves like Busquets, passes like him, looks like him and runs the midfield on his own.
He is brave with pressure and takes the game.
FT: Wales 1-4 Spain
Ethan Ampadu is out on the pitch to shake hands at full-time. He doesn't look to be hobbling so that's good news.
Image source, ReutersWales 1-4 Spain
Wales end on a high. And David Brooks continues to impress on the international stage.
But overall, it was a dominant victory for Spain. They look very handy at the moment.
Wales 1-4 Spain
Danny Gabbidon
Former Wales defender on BBC Radio 5 Live
Only a consolation for Wales but it has got the crowd singing.
The cross had to come from David Brooks, who has been excellent since coming on.
There was not a lot of power on the header but Sam Vokes directed it very well.
Image source, ReutersSam Vokes
David Brooks has been excellent since coming on and it's his excellent cross which makes the goal.
He spins it in off the outside of his boot and Sam Vokes leaps highest to nod the ball into the bottom corner.
That's given the fans something to cheer about!
Image source, reuWales 0-4 Spain
David Brooks gallops into the box and slips it right for Connor Roberts, who is overlapping on the right.
Jose Gaya does well to slide in at the last moment and takes the ball away from Roberts - though he does concede a corner.
Wales 0-4 Spain
Spain immediately have it at the other end and Iago Aspas' shot from close-range is gathered in by Wayne Hennessey.
Image source, ReutersSomeone call 999. Mitro is on fire.
Fulham striker Aleksandar Mitrovic scores his second of the night to seemingly wrap up victory for Serbia in their historic first meeting with neighbours Montenegro.
Poland have set up a frantic finale by pulling a goal back for 3-2 against Portugal through Jakub Blaszczykowski, while it remains goalless between Russia and Sweden heading towards half-time.