Toby Alderweireld limps off holding his groin and Joe Rodon comes on for only his second Premier League appearance.

Joe Rodon's Wales team-mate Gareth Bale was just about to come on, but he's sitting down again now.

Spurs defender Toby Alderweireld is down injured. Wales' Joe Rodon is getting ready.

Image source, BBC Sport

Manchester United make two changes to the side that won 3-1 at Everton before the international break. Alex Telles replaces the injured Luke Shaw to make his Premier League debut, while Nemanja Matic starts ahead of Scott McTominay, who is on the bench.

Marcus Rashford and Victor Lindelof shake off knocks to retain their place in the side, but there's no place in the squad for Paul Pogba.

Man Utd: De Gea, Wan-Bissaka, Lindelof, Maguire, Alex Telles, Matic, Mata, Fred, Bruno Fernandes, Martial, Rashford.

Substitutes: Henderson, Cavani,James, Williams, Van de Beek, Tuanzebe, McTominay.

Image source, BBC Sport

West Brom make four changes to the side beaten 1-0 at home to Tottenham a fortnight ago.

Matheus Pereira and Branislav Ivanovic return to the side after completing a period of self-isolation following a positive test for Covid-19. Romaine Sawyers and Grady Diangana are promoted from the substitutes bench.

Baggies boss Slaven Bilic has confirmed Jake Livermore and Kieran Gibbs miss out as they need to self-isolate after testing positive for coronavirus.

West Brom: Johnstone, Furlong, Bartley, Ivanovic, Ajayi, Townsend, Gallagher, Sawyers, Diangana, Pereira, Grant

Substitutes: Button, Robson-Kanu, Robinson, Phillips, Harper, Krovinovic, O'Shea.

Ellie: Watching the live text bemused. As much as I hope the winning continues, I can't shake the feeling we are only a moment away from throwing it all away.

Scott: Still got 10 plus mins to get to that point where we concede 3 goals. Scott, a terrifyingly nervous Spurs fan.

Gabriel Jesus rides a few tackles and then has a shot blocked and Spurs clear.

Eric Dier isn't the man I'd choose for a 35-yard free-kick. His effort hits the wall.

Harry Kane, the deep-lying playmaker supreme, glides forward and draw a foul. This free-kick is in shooting range.

Giovani Lo Celso's goal after 35 seconds was the quickest by a sub in the Premier League since Bernardo Silva vs Brighton in August 2019 (17 seconds).

It was his first Premier League goal.

Image source, Getty Images

Spurs make a switch now - Lucas Moura on for Steven Bergwijn. Relatively like for like.

Manchester City bring on two England internationals - Raheem Sterling and Phil Foden. Riyad Mahrez and Bernardo Silva are withdrawn.

Aymeric Laporte plays the ball into the box but Eric Dier lets it run back to his keeper.

Image source, Getty Images

I'm not going to pretend I thought Jose Mourinho was going to turn Spurs into title defenders. Fair play to him - he's doing a great job.

Chris Mitchell: Love him or loathe him, you can’t deny Mourinho is back to his absolute best

Rachel: As a success-starved Spurs fan of 40+ years - GIVE ME THIS MOURINHO SPURS ANY DAY!

Image source, Getty Images

Phil McNulty
BBC Sport chief football writer at The Tottenham Hotspur Stadium

Now that is what you call a substitution. Spurs have soaked it up then knocked Manchester City out. Long way back for them now - for all their possession they have looked toothless so far.

The record for assists in a Premier League season is 20 - by Thierry Henry and Kevin de Bruyne.

Harry Kane has nine in nine games.

Image source, Getty Images

It took Giovani lo Celso 35 seconds to score.