Postpublished at 17:04 British Summer Time 16 September 2021
Bayer Leverkusen v Ferencvaros (17:45 BST)
Another of the early kick-offs pits two clubs with Champions League aspirations together, with Bayer Leverkusen hosting Ferencvaros, who are Hungary's most successful club.
They reached the Champions League group stages for the first time since the 1995-96 season last year but returning to the European pinnacle has been a gradual process.
Chief executive Pal Orosz and his team took over a club in a "disastrous situation" in 2011, picking up the pieces after a spell during which they were relegated to the second division because of financial irregularities.
"When we started it was kind of in ruins," he said. "The Albert Stadium that we liked a lot because of the good memories was not up to the European standards, nobody in the club got a salary for more than four months, no bills were paid, no electricity, nothing. We had to invest some money to start with," he says.
"We had to be realistic and see where we can get with our background, with our financial background. You have to set realistic goals and reach them. That is what football is about.
"We said first we have to come back on the Hungarian stage, winning the cup and the championship, and then the next level will be the international stage.
"It was long work. I say this achievement we have is extraordinary - getting into the group stage, starting from the first qualifying round. With our financial background, sporting background, we are a classic 'Europa League group-stage club', so for us (reaching the Champions League last year) is something fantastic."