As it stands, Newcastle are moving above both West Ham and Manchester United into sixth. This has been one of their best performances of the season. Eddie Howe is missing so many players because of injury and suspension but still his side is seriously challenging for a European place.

Ivan Toney remains on the bench as Brentford make just one change to the XI that started their 3-3 draw at Aston Villa last weekend.

Neal Maupay comes in with centre-back Kristoffer Ajer not in the squad at all.

Thomas Frank's side will be aiming to end a nine-game winless streak in the league and welcome back fit-again duo Ethan Pinnock and Kevin Schade on the bench.

Brentford XI: Flekken, Roerslev, Zanka, Collins, Reguilon, Jensen, Janelt, Damsgaard, Mbeumo, Maupay, Wissa.

Subs: Strakosha, Pinnock, Schade, Ghoddos, Onyeka, Toney, Lewis-Potter, Baptiste, Yarmoliuk.

Image source, BBC/ Opta

There is also just one change for Sheffield United following their dramatic 2-2 draw with Chelsea last time out.

Jack Robinson went off with an ankle injury in that game and misses out.

Former Liverpool wing-back Yasser Larouci replaces him.

Sheffield United XI: Grbic, Holgate, Ahmedhodzic, Trusty, Bogle, Hamer, Arblaster, Osborn, Larouci, Brereton Diaz, McBurnie.

Subs: Foderingham, Archer, Norwood, Souza, Slimane, McAtee, Curtis, Osula, Brooks.

Image source, BBC/ Opta

Burnley manager Vincent Kompany will be absent from the dug-out at Turf Moor this afternoon as he serves a one-game touchline ban imposed after last month's red card at Chelsea.

He makes two changes to the side that lost to Everton last time out.

Dara O'Shea is suspended for picking up a red card at Goodison Park last week while Charlie Taylor drops to the bench.

In come Hjalmar Ekdal and Vitinho while goalkeeper James Trafford is on the bench having recovered from illness.

Burnley XI: Muric, Assignon, Esteve, Foster, Cullen, Berge, Bruun Larsen, Odobert, Fofana, Ekdal, Vitinho.

Subs: Trafford, Taylor, Gudmondson, Brownhill, Rodriguez, Manuel, Amdouni, Tresor, Massengo.

Brighton boss Roberto de Zerbi continues to struggle with injuries with nine first-team players sidelined.

Among those are Julio Enciso and Tariq Lamptey, who are both missing having started in the defeat by Arsenal last time out.

In come Joao Pedro and Joel Veltman while the Seagulls have been forced to turn to their academy with youngsters Cameron Peupion, Mark O'Mahony and Odeluga Offiah all on the bench.

Brighton XI: Verbruggen, Van Hecke, Dunk, Estupinan, Baleba, Gross, Adingra, Moder, Welbeck, Pedro, Veltman.

Subs: Steele, Julio, Lallana, Barco, Fati, Buonanotte, Offiah, Peupion, O'Mahony.

Jack: Second week in a row Maddison has somehow avoided a red card. Liability from a leadership perspective

Nuno Espirito Santo makes one change to the Nottingham Forest side that started last weekend’s 3-1 defeat at Tottenham.

USA international Giovanni Reyna makes his first start since joining the club on loan from Borussia Dortmund, with Anthony Elanga missing out with a minor injury.

Nottingham Forest XI: Sels, Williams, Omobamidele, Murillo, Aina, Yates, Danilo, Reyna, Gibbs-White, Hudson-Odoi, Wood.

Subs: Turner, Tavares, Sangare, Toffolo, Dominguez, Niakhate, Origi, Montiel, Ribeiro.

Image source, BBC Sport

Gary O’Neil also makes one chage to the Wolves team that lost 2-1 at home to West Ham last Saturday.

Rayan Ait-Nouri misses out with a minor issue, but Matheus Cunha returns to the starting XI after recovering from a muscle injury.

Fit-again Hwang Hee-chan is named in the matchday squad for the first time since late February.

Wolves XI: Sa, S Bueno, Kilman, Toti, Nelson Semedo, Lemina, Joao Gomes, Doherty, Sarabia, Doyle, Matheus Cunha.

Subs: Bentley, King, Traore, Hwang, Dawson, H Bueno, Barnett, Chirewa, Fraser.

Image source, BBC Sport

Emlyn Begley
BBC Sport at Etihad Stadium

A couple of headline bits of news from the Manchester City XI as goalkeeper Ederson returns to the starting line-up after a month out and Rodri is rested.

The midfielder is on the bench alongside Phil Foden - who was an injury doubt.

Manchester City make six changes from the side who drew with Real Madrid, with Kevin de Bruyne, Jeremy Doku, Matheus Nunes, Rico Lewis, Julian Alvarez and Ederson coming in. John Stones misses out entirely.

Man City XI: Ederson, Akanji, Dias, Gvardiol, Lewis, Kovacic, Matheus, Alvarez, De Bruyne, Doku, Haaland.

Subs: Ortega, Walker, Ake, Grealish, Rodri, Silva, Gomez, Foden, Bobb.

Luton make two changes to the side who beat Bournemouth last weekend.

Teden Mengi misses out through injury and Issa Kabore is ineligible to face his parent club - so Luke Berry and Fred Onyedinma come in.

Luton XI: Kaminski, Onyedinma, Hashioka, Burke, Doughty, Chong, Barkley, Berry, Clark, Morris, Townsend.

Subs: Shea, Krul, Woodrow, Ruddock, Johnson, Harris, Chigozie, Nelson, Piesold.

Ironic cheers from Newcastle fans as James Maddison whips an attempt over the bar from outside the box. Tottenham have registered two attempts on target but have rarely threatened.

Midway through the second half. It feels like the points are in the bag for Newcastle but the home side show no sign of easing off the gas. They're keen to extend their advantage.

Tottenham's next game? A derby against Arsenal. They're going to have to sort themselves out for that one.

Image source, Getty Images

All the chances are falling Newcastle's way.

Now Elliot Anderson forces a smart save from Guglielmo Vicario.

By the way, Newcastle's corner count is up to 14.

Ouch!

James Maddison's high boot connects with Jacob Murphy.

A nailed-on yellow card for the Tottenham player.

Some fans inside St James' Park wanted to see a red.

Pat Nevin
Former Chelsea and Scotland winger on BBC Radio 5 Live

Image source, Reuters

I am amazed Ange Postecoglou didn't do it [make substitutes] at half-time. He has left it till they are three down and it's probably too late now.

I think Tottenham fans are in a state of shock. Tottenham haven’t played well and have not battled.

We will see if these changes make a difference.

Nothing is going right for the visitors. Cristian Romero has joined Micky van de Ven and Yves Bissouma in the referee's notebook.

Ange Postecoglou is making changes. Captain Son Heung-min is among those coming off. So too Yves Bissouma and Rodrigo Bentancur.

Dejan Kulusevski, Pierre-Emile Højbjerg and Pape Sarr are on.

Almost 4-0!

A set-piece by Anthony Gordon nearly finds Alexander Isak who is hunting a hat-trick.

It flashes just wide.

Alexander Isak's Premier League tally rises to 17. He has five in his past four top flight appearances.