Nick Isiekwe, who was born in 1998 (yes, really), comes on to the field to replace Charlie Ewels.

And captain Dylan Hartley is on for Jamie George.

This game is done and dusted but can the bench make an impact once again?

Image source, Reuters

Jason White
Former Scotland international on BBC One

It must be a brilliant side to be playing in at the moment. Scotland are full of confidence and I'm delighted for John Barclay, who has been outstanding recently.

If we can have our best players fit and playing well ready for the Six Nations next year, then maybe 2018 could be a really successful year for Scotland.

Gus Jones Jewellers: Ouch! What a beating! @Scotlandteam, external that is a cricket score and absolute domination over the poor old @qantaswallabies, external - say, cricket score and domination over Aussies? Let's hope that's not the last time we say that this weekend please...?

Natalie Wood: That was something special for Scotland! I wonder if Wales can do the same against New Zealand

Craig Fraser: 53 points against Australia. Revenge for world cup 2 years ago

Scotland head coach Gregor Townsend on BBC One: "It's an amazing result. To score this many points against the world number three side is brilliant. Of course you have to take into account the red card but we kept the mindset of wanting to work hard and we got our rewards.

We showed what we were about and it takes a lot to show that in attack. It wasn't perfect but it suited us to have a one-man advantage.

On Stuart Hogg's absence: "It shows we've got a good depth. Byron McGuigan was brilliant on his first start. And the team is resilient. They showed that last week against New Zealand."

Australia captain Michael Hooper: It's an incredibly disappointing way to finish the season. A real low point and disappointing to send off influential players like Stephen Moore. Congratulations to Scotland though and the crowd were fantastic for them.

On the red card: We'll have to review it when we get back but you live and die by your own decisions. We had to fight our way out of the situation we found ourselves in and unfortunately we weren't able to do so.

It's been a rollercoaster year for us as a team. It's tough to take.

While Champagne soaks Murrayfield, it's all a bit flat here at Twickenham.

England are being very respectful in not detracting from the Scottish performance.

Scotland's man-of-the-match Byron McGuigan: It was fantastic to get such a win against a world class team. I was blown away by the crowd and the peformance. The boys have been working really hard across all three Tests and for it to pay off like this is outstanding.

An awesome achievement from everyone. We were really unlucky last week and to follow it up like this is amazing.

Scotland captain John Barclay gets a huge reception from the crowd as he speaks live on BBC One: "I don't know what to say. The atmosphere last week was the best ever. It's fantastic to back it up. I feel like the atmosphere is special here now.

"We had to park last week fast, we know it's easy to do a one-off performance. the All Blacks can do that week in week out. We have to back up performances and we played well today and got the rewards."

He's off to receive the Hopetoun Cup from Princess Anne.

Richad Wilkinson: Dame Edna, Paul Hogan, Ned Kelly, Skippy The Bush Kangaroo, Waltzing Matilda, Kylie Minogue, Hugh Jackman, Chopper Harris, Mel Gibson your boys took one helluva beating

Paul Leonard: Wow, wow, wow what an effort by Scotland

Mr H: Awesome Scotland! And up to 4th in the world... Toony’s army on the march...

England attack, Samoa turn it over. 15 minutes of the second half and that's all we've seen.

This time it's number eight Jack Lam over Maro Itoje and the England lock is wrapped up.

Eddie Jones has seen enough and on comes Harry Williams, with Dan Cole heading to the bench.

This Samoan side are absolutely killing the breakdown. This is a different side out there in the second half.

Elliot Daly places the ball back but a wall of blue envelops him and Samoa are awarded another penalty at the breakdown. England need to get numbers in these rucks, they're being bulldozed at the moment.

Andy Robinson
Former England and Scotland head coach on BBC One

After the pressure of last week's performance, Scotland had to raise their game again. Well done to all the Scottish players. They've all played and performed to their best and it's been a joy to watch how well they have played as a team today.

Look at him roar!

A record victory for the Scots.

What a match!

Tim Nanai-Williams and Jack Lam combine to turn the ball over. Alex Lozowski gets isolated in the tackle and the visitors earn a penalty.

England have been wasteful with their possession this half, and the scoreline remains the same.

Certainly no drama here.

More drama.

Byron McGuigan is racing over to the corner to touch the ball down and Kurtley Beale gets there first, slapping the ball away.

It's going to go down as a deliberate knock-on. Beale isn't happy as he's sin-binned for the second game in a row.

Australia down to 13 and Scotland have a dangerous line-out.

Scotland chase another attack from a scrum inside the Australia half before replacement half-back Nick Phipps clears the danger.

They want more...