Novak Djokovic loses to unseeded Italian Marco Cecchinato
World number 72 wins 6-3 7-6 (7-4) 1-6 7-6 (13-11) to reach semi-finals
Djokovic struggled with shoulder/neck problem early on
Austrian seventh seed Dominic Thiem beats Alexander Zverev 6-4 6-2 6-1
German second seed Zverev had hamstring problem
Madison Keys beats Yulia Putintseva 7-6 6-4 in women's quarter-finals
Sloane Stephens beats Daria Kasatkina 6-3 6-1
*Zverev 4-6 2-6 0-2 Thiem
Thiem opens up the body and launches a forehand assault before slamming deep on to the Zverev side from the net, but the ball whizzes back past him with interest.
The French crowd loved that from the 21-year-old German.
No such mistake off the next one. Thiem holds.
Zverev 4-6 2-6 0-1 Thiem*
A shake of the head from the German, his youthful locks tucked behind a bright orange sweatband. It comes after another stroke drifts narrowly off target when he looked like taking the point.
40-15.
Leon Smith
GB Davis Cup captain on BBC Radio 5 live sports extra
It's pretty tough to watch when you see Zverev looking so flat. He needs to try to fire himself up and go for it.
Zverev 4-6 2-6 0-1 Thiem*
Well, well, well.
Zverev looked to have Thiem beaten on about three occasions in that mammoth rally, but the Austrian just kept flicking a wrist and getting it back.
Eventually Zverev is done with that cat and mouse game, sauntering into the net to fire down a volleyed winner.
15-15.
Zverev 4-6 2-6 0-1 Thiem*
Thiem takes it! The Austrian breaks early in the third set.
*Zverev 4-6 2-6 0-0 Thiem
High, wide, not at all handsome from Zverev as he misjudges a forehand and jabs it off his frame towards our own Jonathan Jurejko in the press box...
He finds himself two break points down.
Yulia Putintseva 6-7 (5-7) 4-6 Madison Keys
It is all over on Court Suzanne-Lenglen and Madison Keys has won in two sets to move into her first French Open semi-final.
She will play either fellow American Sloane Stephens or Daria Kasatkina, who play next up on Court Philippe-Chatrier.
It will be a repeat of the 2017 US Open final if Stephens wins her quarter-final.
Image source, AFP*Zverev 4-6 2-6 0-0 Thiem
Alexander Zverev to serve first in the third set. But Dominic Thiem takes the opening point.
Thiem then pounds a deep forehand long. That's 15-15.
Jonathan Jurejko
BBC Sport at Roland Garros
Another warm ovation for Zverev as he comes back on to court. The crowd want to see more tennis.
*Zverev 4-6 2-6 0-0 Thiem
And here comes the world number three.
He's not throwing in the towel just yet.
*Zverev 4-6 2-6 0-0 Thiem
Dominic Thiem uses the opportunity to visit the Chatrier bathrooms himself.
He's back out on court nice and sharpish, with one foot already in a third consecutive French Open semi-final...
A few stretches to keep nice and loose for the Austrian as he awaits Zverev's return.
Yulia Putintseva 6-7 (5-7) 4-5* Madison Keys
One hold of serve will take Madison Keys into the French Open semi-finals for the first time in her career.
*Zverev 4-6 2-6 0-0 Thiem
Alexander Zverev is heading to the dressing room for some treatment, or a toilet break... maybe both.
He's played three successive five-setters to get here, but has never come back from 2-0 down to win a Grand Slam match.
*Zverev 4-6 2-6 0-0 Thiem
That's the second set. Dominic Thiem takes it.
What does Alexander Zverev do now?
Zverev 4-6 2-5 Thiem*
Thiem pulls Zverev around the court, but the German hustles his way from one side of the baseline to the other until a patted forehand drops long.
40-0.
Three set points.
Zverev 4-6 2-5 Thiem*
Dominic Thiem serving for a two-set lead.
Leathers down an ace to get things under way...
Leon Smith
GB Davis Cup captain on BBC Radio 5 live sports extra
Zverev is there on the court but it's like his mind is elsewhere.
He knows the longer this goes on the more likely it is there will be some significant damage.
He's going to have to go for it now and throw caution to the wind.
Yulia Putintseva 6-7 (5-7) 3-4* Madison Keys
There is a great incentive for Madison Keys to progress further than fellow American Sloane Stephens, as one of them will leave the event as the top-ranked female American player.
Keys and Stephens could meet in the semi-finals, with Keys doing her part so far, leading 7-6 (7-5) 4-3 against Yulia Putintseva with a break of serve in the second set.
Before the tournament started, Venus Williams was the highest American in the rankings at ninth, with Stephens 10th and Keys 13th.
Image source, WTA InsiderZverev 4-6 2-5 Thiem*
Zverev punches a forehand long.
Deuce.
A huge serve wide out has Thiem stretching and just about touching string to ball, but to no avail.
Zverev holds.
Jonathan Jurejko
BBC Sport at Roland Garros
More encouragement from the crowd as a dejected-looking Zverev waits for some balls to serve with. The tall German leans with his racquet on an advertising board, twirling it on the top, while stood cross legged.
Looking a long way back...