Image source, Reuters

Following that latest update from police, here's everything we know so far:

The victims:

• Two people have died following an attack at the Heaton Park synagogue in north Manchester
• Three more members of the public are in a serious condition, police say

The suspect:

• Another person - a man believed to be the suspect - was shot by Greater Manchester Police and is also believed to be dead, officers say
• But police say the suspect's condition cannot be confirmed due to "suspicious items on his person", with a bomb disposal unit at the scene

The attack:

• Police received reports of a car being driven towards people, and a man holding a knife, outside the synagogue on Middleton Road in Crumpsall, Manchester at about 09:30
• The attack took place on Yom Kippur, the holiest day in the Jewish religious calendar
• Police say a large number of people worshipping at the synagogue at the time of the incident "were held inside while the immediate area was made safe, but have since been evacuated"
• An eyewitness, talking to BBC Radio Manchester, describes seeing a man "bleeding out on the floor" and another holding a knife - the witness, Gareth, says police soon arrived and gave the man holding a knife "a couple of warnings" before they "opened fire"

Emergency meeting:

• PM Keir Starmer is flying back early from a summit in Denmark to chair an emergency meeting - he says there'll be extra police "assets" at synagogues across the UK and the fact this happened on Yom Kippur "makes it all the more horrific"

Image source, Getty Images

We're now hearing from the King, who says he and Queen Camilla are "deeply shocked and saddened" to hear about the attack in Manchester.

"Especially on such a significant day for the Jewish community," he says in a statement.

"Our thoughts and prayers are with all those affected by this appalling incident and we greatly appreciate the swift actions of the emergency services."

Greater Manchester Police says "three other members of the public remain in a serious condition".

"A large number of people worshipping at the synagogue at the time of the incident were held inside while the immediate area was made safe, but have since been evacuated," it adds.

The bomb disposal unit has been called and is now at the scene, Greater Manchester Police says.

Image source, Getty Images

More from the police now: "A third person, a man believed to be the offender, was shot by GMP Firearms Officers and is also believed to be deceased."

Police say the suspect's condition cannot be confirmed due to "suspicious items on his person", with a bomb disposal unit at the scene.

Greater Manchester Police says two people have died following the major incident.

Olivia Gold, who lives in the area, came to see what was happening when she heard helicopters overhead.

"It's just horrendous," she tells PA Media. "We're a quiet community, just leave us alone. We don't want any of this.

"It's just four people who have been injured - thankfully no one was killed as far as I know.

"I think the response by police has been absolutely brilliant. They got here really, really quickly."

Image source, PA Media

Video footage appears to show moment police open fire at Manchester Synagoguepublished at 12:04 BST 2 October

12:04 BST 2 October

By Matt Murphy

Warning: This post contains graphic content

As we've been reporting, BBC Verify has authenticated footage circulating online which appears to show the moment police opened fire on a man at the Manchester Synagogue.

In the clip - which appears to have been taken by a passerby - two armed officers can be seen standing pointing their weapons at a figure lying prone on the ground.

As the camera pans, a different person is seen lying at the gate to the synagogue surrounded by a pool of blood and a black car stopped immediately to his right.

One of the officers then approaches the fence, where a small group of people had gathered, and shouts: "Everybody else, he has a bomb. Go away."

Seconds later the figure being watched by police appears to attempt to stand up. Sharp cracks ring out and the man falls to the ground.

Today's incident comes on Yom Kippur - the holiest day in the Jewish calendar.

And we're now seeing images of people gathering outside the synagogue in Manchester where the stabbing took place.

Image source, Getty Images

Image source, Getty Images

Image source, Getty Images

Image source, Reuters

Prime Minister Keir Starmer says "additional police assets" will be deployed at synagogues across the country after the attack in Manchester.

Speaking as he flew back to the UK from a summit, to chair an emergency meeting on the incident, Starmer says: "We will do everything to keep our Jewish community safe."

Warning: This post contains graphic content

Our colleagues at BBC Radio Manchester have been speaking to Gareth, an eyewitness, who says he was driving his delivery van at the time of the incident.

He says he was held back in traffic, assumed it was a "normal collision", but as he got closer he saw a man "bleeding out on the floor".

Gareth says he saw another man "laying on the floor" in front of a car, and he could hear people shouting.

He then describes seeing another person, a man, who he says had a knife and was "stabbing the window" of a nearby building "trying to get in".

"Within seconds, the police arrived, they gave him a couple of warnings, he didn’t listen so they opened fire," Gareth explains, saying the man holding the knife then went down on the floor.

The man then "started getting back up and they [the police] shot him again", Gareth says - describing it as "nerve-racking" to see.

Where did the attack take place?published at 11:38 BST 2 October

11:38 BST 2 October

By Matt Murphy

Police say this morning's attack took place at the Heaton Park synagogue in the Crumpsall area of Manchester.

Officers were called to the scene at 09:31 BST, Greater Manchester Police said in a statement.

It's about 4 miles (6km) from the city centre of Manchester:

Anna Jameson
Reporting from the scene

I’m currently standing at the police cordon just on the edge of Middleton Road, where the incident has taken place.

Helicopters are flying overhead, we’ve got sirens going every two minutes and police have cordoned off the site. I’ve seen paramedics and the fire service all on site.

A major incident - and Operation Plato - has been declared.

Lots of members of the public, including members of the Jewish community, are gathering round now to see what has happened.

Understandably, this is a huge shock to the people of Greater Manchester this morning.

Image source, PA Media

Asked about the synagogue attack in Manchester, Conservative leader Kemi Badenoch tells the BBC it looks like "an outrageous attack on the Jewish community on their holiest day" - calling it "vile and disgusting".

Police tell the BBC one of those injured is a security guard.

To recap, police say four people were hurt in the attack and the suspect was shot. The Manchester mayor says the suspect is believed to be dead, but their condition hasn't yet been confirmed.

Here's a fuller rundown of what we know so far.

Chris Mason
Political editor

The prime minister will chair a meeting of the government’s emergency Cobra committee in London this afternoon.

COBR meetings, also known as Cobra, involve a gathering of senior ministers and officials in London to coordinate the emergency response to a crisis. COBR stands for Cabinet Office Briefing Rooms.

Chris Mason
Political editor

Image source, Reuters

The prime minister is to fly back from the European Political Community gathering in Copenhagen early, after the attack at a synagogue in Manchester.

Keir Starmer has been briefed in the last few minutes in the Danish capital, and will return home shortly.

We're verifying footage from the attackpublished at 11:13 BST 2 October

11:13 BST 2 October

By Kayleen Devlin

BBC Verify has been looking at footage linked to the attack at a synagogue in Manchester.

The video shows armed police officers outside a synagogue on Middleton Road standing in front of a person lying on the ground.

Another person outside the synagogue is also lying on the ground surrounded by blood.

We matched images from the footage with what we could see on Google Maps to verify the location.

We've just had this statement from Prime Minister Keir Starmer:

"I’m appalled by the attack at a synagogue in Crumpsall.

"The fact that this has taken place on Yom Kippur, the holiest day in the Jewish calendar, makes it all the more horrific.

"My thoughts are with the loved ones of all those affected, and my thanks go to the emergency services and all the first responders."

Daniel Sandford
Home affairs correspondent

Police said they declared "Plato" moments after first hearing about the incident.

Operation Plato is a set of responses by the emergency services to large-scale incidents including "marauding terrorist attacks".

When police declare Operation Plato, the other emergency services such as the ambulance service then have protocols that they follow.

For example, NHS trusts will activate their major incident plans.