David Cameron to resign as Prime Minister
The UK has voted to leave the European Union after 43 years in a historic referendum
Leave has won by 52% to 48%
East of England votes to Leave by nearly 57% to 43%
Value of the pound falls to its lowest level since 1985
So what next...?
The Brexit is coming, but what challenges lie ahead before we get there? The BBC's Laurence Peter has more...
Image source, AFPComplex negotiations lie ahead now that the UK has voted for Brexit, the BBC's Laurence Peter reports.
Read MoreThe Labour leader of Corby Borough Council, and Remain campaigner, has tweeted a sarcastic "Happy Independence Day"...
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And made it clear who he thinks will take over from David Cameron...
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Andrea Leadsom is currently fourth favourite to be the next Conservative leader, and Prime Minister.
She is around 10/1 for the job behind Boris Johnson, who is the favourite, Theresa May and Michael Gove.
Peter Bone is 200/1.
As David Cameron announces he is stepping down as Prime Minister, Labour leader Jeremy Corbyn is also facing criticism.
It comes after many traditional Labour areas, particularly in the north, opted decisively for Brexit.
Kelvin Hopkins, Labour MP for Luton North and a Leave campaigner, backed Mr Corbyn for the party leadership, but said: "Labour's got to ensure it reconnects - if it's disconnected - with its working class support.
"We are the party of the trade union movement, working class people, we were founded to defend the interests of the less well off and the ordinary workers."
Remain campaigner Andrew Selous, the Conservative MP for South West Bedfordshire, has been reacting to David Cameron's decision to step down in October.
"I do understand his decision and I think it is the right decision," he said. "While this has been a referendum, quite frankly, it has taken on something of the nature of a general election."
Image source, Conservative PartyThe process for the UK's withdrawal from the European Union is not a simple process.
The MP for Northampton North, Michael Ellis, has called the result of the EU referendum "historic and monumental".
The Conservative politician praised departing Prime Minister David Cameron, but said the decision was "bigger than any one politician".
Conservative MP for Northampton North and Remain campaigner, Michael Ellis, said David Cameron has been a "fantastic leader and a brilliant prime minister," but talking about the Prime Minister's resignation added "that's the power of democracy".
Following the vote for Leave, Mr Ellis said "we must come together" saying the decision was "bigger than any one politician".
The Conservative MP, who is also a constitutional expert, said the position of Scotland and Northern Ireland "would need to be looked at".
The Conservative MP for North East Bedfordshire, Alistair Burt, who campaigned to stay in the EU said he "misjudged" the mood in the country.
"This sense of being out of touch - perhaps on immigration over many years - maybe that's true?" he said.
He added it is now up to MPs, whichever way they voted, "to try and say 'right, what happens next" - there'll be a lot of uncertainty, how do we make the best decisions now for the people in our constituencies?"
Broxbourne MP Charles Walker is one of 84 Conservative MPs who campaigned for a Leave vote who signed a letter urging David Cameron to stay on as Prime Minister.
He said: "I'm delighted by the result, it's what I campaigned for - as for the Prime Minister, I'm sorry he made that decision... I'm a little surprised."
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Prime Minister David Cameron has announced at Downing Street that he is to step down following confirmation that voters have backed Brexit.
His voice breaking, Mr Cameron said: "I love this country and I feel honoured to have served it and I will do everything I can in future to help this great country succeed."
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Laura Kuenssberg tweets:
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Pete Cooper
BBC Local Live
You went to the polls...
The votes were then counted...
With the result being sent to Kettering...
The Leave and Remain camps anxiously await the result...
And finally it was declared that the the East Midlands, in line with the rest of the UK voted to leave the EU...
The national outcome in the EU Referendum has been welcomed by the East Midlands UKIP MEP Margot Parker.
She said: "It's a phenomenal result... it's terrific, it's exciting, I'm full of hope and optimism for the future but more than that the people have actually reclaimed this vote, they've made it count and God bless them for that, that's fantastic."
Pete Cooper
BBC Local Live
The Northampton Chronicle & Echo have reaction from Northamptonshire politicians, external to the win for the Leave campaign including Emma McClarkin, Conservative MEP for the East Midlands who told the paper that "A new day has dawned for the British people".
The Bucks Free Press has an interview with Wycombe MP Steve Baker, external, who says the government will need to adjust" to the leave vote.
The Hertfordshire Mercury say that "in Mercury land", the decision was split, external with one of the closest votes coming in East Herts where just 622 votes separated the two campswith the Leave campaigners getting the nod.
And Luton Today has the results for Luton and Central Bedfordshire, who both voted to leave, external.
Andrew Sinclair
BBC Look East political correspondent
The region has made it very clear that it wants nothing more to do with the EU.
From talking to campaigners and from being out on the campaign trail, it's very clear that concerns about the pressure caused by immigration were at the forefront of peoples' minds.
But there was also deep-seated anger against the political class.
BBC political editor Laura Kuenssberg has blogged.
She writes: "David Cameron's closest colleagues say that he's a lucky politician. When it comes to the biggest gamble of his career, his luck has dramatically run out."
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As the East of England votes to Brexit, you've been having your say on the BBC Look East Facebook page. Keep your comments coming, external.
